MDM2+/CDK4+/p53+ oral liposarcoma: Case report and review of the literature

Well-Differentiated Liposarcoma/Atypical Lipomatous Tumor of the Oral Cavity: Report of Three Cases and Review of the Literature

“…The mean age of 64 patients with available information was 54.05 ± 17.84 years (age range 6 months to 86 years; median 54 years), with 78.1% of patients (50/64) being C40 years-old. This finding is in accordance with the previously reported mean age at diagnosis for intraoral liposarcomas, regardless of histologic subtype [9,38].…”

“…As has been shown in previous studies, head and neck liposarcomas [7,12] and intraoral liposarcomas [8][9][10] show a male predominance, in contrast to the reported female predilection for ALT/WDLS's of various locations [1,6,42]. The mean age of 64 patients with available information was 54.05 ± 17.84 years (age range 6 months to 86 years; median 54 years), with 78.1% of patients (50/64) being C40 years-old.…”

“…In general, superficially located liposarcomas behave in a rather benign manner, in contrast to deep-seated lesions, such as retroperitoneal or mesenteric liposarcomas. Most intraoral liposarcomas are usually superficial and well circumscribed, although they lack a true capsule and satellite nodules may be seen infiltrating adjacent tissues [9,10]. A B5.0 cm maximum diameter is considered a favorable prognostic marker for oral liposarcomas [8].…”

“…Oral liposarcomas show a much lower incidence, as relevant reviews have reported a limited number of documented cases [8][9][10][11]. In a review of head and neck liposarcomas between 1911 and 2005, approximately 46% of cases (36/78) were localized in the oral mucosa [11], while oral and salivary gland liposarcomas accounted for only 0.3% (18/5,435) of all liposarcomas diagnosed in the Armed Forces Institute of Pathology between 1970 and 2000 [8].…”

“…Although ALT/WDLS is the most common type of liposarcoma of the oral mucosa [1,[8][9][10]12], pertinent data are limited because most relevant publications have been in the form of either single case reports or small case series. In this study, three additional cases of oral ALT/WDLS are described and a review of the reported oral ALT/WDLS cases in the English language literature is also presented.…”