Well-Differentiated Liposarcoma/Atypical Lipomatous Tumor of the Oral Cavity: Report of Three Cases and Review of the Literature

Abstract

Atypical Lipomatous Tumor/Well Differentiated Liposarcoma (ALT/WDLS) is a soft tissue sarcoma of intermediate malignant behavior, most frequently affecting the retroperitoneum and lower extremities. Oral liposarcomas are very rare neoplasms, the most common histological subtype being ALT/WDLS. In this study, three additional cases of ALT/WDLS located on the tongue (2 cases) and the lower lip (1 case), respectively, are described. Analysis of the salient clinicopathologic features of 63 oral ALT/WDLS cases previously reported in the English language literature, as well as of the 3 cases presented in this study, indicates that the indolent biologic behavior of this tumor justifies its designation as a locally spreading malignant neoplasm, affording a rather conservative surgical approach.

Submucosal nodule in buccal mucosa

“…It manifests as a circumscribed, painless, and slow-growing submucosal mass, with an average size of 3.3 cm. 10 These characteristics are compatible with the present report.…”

Spindle Cell Lipoma of the Tongue: A Clinicopathologic Study of 8 Cases and Review of the Literature

“…A recent review of oral cavity atypical lipomatous tumor/ well differentiated liposarcoma showed the tongue specifically to be involved in 55 % of cases [29]. Similar to spindle cell lipomas, liposarcomas affecting the tongue typically present clinically as painless, slow growing masses [29,30].…”

“…A recent review of oral cavity atypical lipomatous tumor/ well differentiated liposarcoma showed the tongue specifically to be involved in 55 % of cases [29]. Similar to spindle cell lipomas, liposarcomas affecting the tongue typically present clinically as painless, slow growing masses [29,30]. Histologically, atypical lipomatous tumor/ well differentiated liposarcoma can exhibit a spindle cell component that can lead to confusion with spindle cell lipoma [29,30].…”

“…Similar to spindle cell lipomas, liposarcomas affecting the tongue typically present clinically as painless, slow growing masses [29,30]. Histologically, atypical lipomatous tumor/ well differentiated liposarcoma can exhibit a spindle cell component that can lead to confusion with spindle cell lipoma [29,30]. Features that distinguish atypical lipomatous tumor/well differentiated liposarcoma from spindle cell lipoma include significant variation in adipocyte size and shape, fibrous septa with atypical stromal cells exhibiting nuclear hyperchromasia, and the presence of more than an occasional lipoblast [29,30].…”

Tiroid Ultrasonografisi Sırasında Tespit Edilen Servikal Lipom: İki Olgu Sunumu

“…Atipik lipomatöz tümör/iyi diferansiye liposarkomlar liposarkom vakalar n n %40-45'ini olu turur ve en s k adipoz doku malign tümörüdür. S kl kla retroperitoneal bölgede yerle seler de boyun bölgesi de s k yerle im bölgelerinden biridir 7 . yi diferansiye liposarkomlar tipik olarak iyi s n rl , multi-lobule ve heterojen ekoda görülürler.…”