MCS-18, a novel natural product isolated from Helleborus purpurascens, inhibits dendritic cell activation and prevents autoimmunity as shown in vivo using the EAE model

Horstmann, Brigitte; Zinser, Elisabeth; Turza, Nadine; Kerek, Franz; Steinkasserer, Alexander

doi:10.1016/j.imbio.2007.09.016

Cited by 20 publications

(17 citation statements)

References 34 publications

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“…One encouraging study showed that inducing liver regulatory DCs by administering Toll-like receptor agonists could lead to the remission of autoimmune disease. 137 These liver tolerogenic mechanisms may also be useful in preventing transplant rejection. 138,139 Thus, tolerization by liver APCs may be an effective approach to prevent antigen-specific allograft rejection and cure autoimmune disease.…”

Section: Future Directionsmentioning

confidence: 99%

The liver works as a school to educate regulatory immune cells

Tian

2013

Cell Mol Immunol

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Because of its unique blood supply, the liver maintains a special local immune tolerogenic microenvironment. Moreover, the liver can impart this immune tolerogenic effect on other organs, thus inducing systemic immune tolerance. The network of hepatic regulatory cells is an important mechanism underlying liver tolerance. Many types of liver-resident antigen-presenting cells (APCs) have immune regulatory function, and more importantly, they can also induce the differentiation of circulating immune cells into regulatory cells to further extend systemic tolerance. Thus, the liver can be seen as a type of 'school,' where liver APCs function as 'teachers' and circulating immune cells function as 'students.'

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Section: Future Directionsmentioning

confidence: 99%

The liver works as a school to educate regulatory immune cells

Tian

2013

Cell Mol Immunol

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“…It was also proved that MCS-18 induces a long-lasting suppressive effect and is able to inhibit the expression of typical molecules of mature dendritic cells (DC). This compound impeded the formation of the typical DC/T-cell clusters, which are essential to induce potent immune responses [94]. Another paper that supported the above mentioned facts, added that MCS-18 also reduced B-cell proliferation and immunoglobulin production [95].…”

Section: Immunomodulatory Activitymentioning

confidence: 92%

“…Using EAE assay in vitro as well in vivo the authors were able to show that MCS-18 exerts a strong immunosuppressive activity with remarkable potential for the therapy of diseases characterized by a pathologically over-activated immune system. They concluded that MCS-18 is an efficient modulator of immune response in vitro and in vivo and that is able to inhibit the disease symptoms at different stages [94]. The authors demonstrated that MCS-18 has a very potent non-toxic immune-suppressive activity and their results were strongly supported by clinical trial data reporting that MCS-18 is a highly effective drug in the treatment of arthritis.…”

Section: Immunomodulatory Activitymentioning

confidence: 93%

Natural compounds with important medical potential found in Helleborus sp.

Maior

Dobrotă²

2013

Open Life Sciences

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Helleborus (family Ranunculaceae) are well-known as ornamental plants, but less known for their therapeutic benefits. Over the past few years, Helleborus sp. has become a subject of interest for phytochemistry, pharmacology and other medical research areas. On the basis of their usefulness in traditional medicine, it was assumed that their biochemical profile could be a source of metabolites with the potential to overcome critical medical issues. There are studies involving natural extracts from these species which demonstrate that Helleborus plants are a valuable source of chemical compounds with great medical potential. Some phytochemicals produced by these species have been separated and identified a few decades ago: hellebrin, deglucohellebrin, 20-hydroxyecdysone and protoanemonin. Lately, many other active compounds have been reported and considered as promising remedies for severe diseases such as cancer, ulcer, diabetes and also for common medical problems such as toothache, eczema, low immunity and arthritis. This paper is an overview of the Helleborus genus focusing on some recentlydiscovered compounds and their potential for finding new drugs and useful biochemicals derived from these species.

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“…MCS-18, which chemically is classified as a macrocyclic carbon suboxide (C3O2)n derivative in analogy to polyketides defined on their turn as polymers of the "ketide" unit (H2C C O)n, has been prepared as previously described [15]. Shortly: 1 kg of dried and hexane-defatted roots of H. purpurascens (i.e.…”

Section: Mcs-18mentioning

confidence: 99%

“…Thus, the use of pure natural products, such as MCS-18, represents an interesting new strategy. Preclinical investigations have already shown the efficacy of MCS-18 in anti-inflammatory and autoimmune disease models, including the EAE-model [15]. Using this model it could be shown that MCS-18 prevents and/or reduces paralyses symptoms.…”

Section: Introductionmentioning

confidence: 99%