MCS-18, a novel natural plant product prevents autoimmune diabetes

Seifarth, C.; Littmann, Leonie; Resheq, Yazid J.; Rößner, Susanne; Goldwich, Andreas; Pangratz, Nadine; Kerek, Franz; Steinkasserer, Alexander; Zinser, Elisabeth

doi:10.1016/j.imlet.2011.04.016

Cited by 10 publications

(2 citation statements)

References 36 publications

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“…In the animal group which had been treated with MCS-18, 70% of the animals showed a diabetes free survival, in comparison with untreated animals where only less than 10% were free of diabetes. These studies showed that MCS-18 exerts an efficient immunosuppressive activity with remarkable potential for the therapy of diseases characterized by pathological over-activation of the immune system [96].…”

Section: Immunomodulatory Activitymentioning

confidence: 99%

Natural compounds with important medical potential found in Helleborus sp.

Maior

Dobrotă²

2013

Open Life Sciences

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Helleborus (family Ranunculaceae) are well-known as ornamental plants, but less known for their therapeutic benefits. Over the past few years, Helleborus sp. has become a subject of interest for phytochemistry, pharmacology and other medical research areas. On the basis of their usefulness in traditional medicine, it was assumed that their biochemical profile could be a source of metabolites with the potential to overcome critical medical issues. There are studies involving natural extracts from these species which demonstrate that Helleborus plants are a valuable source of chemical compounds with great medical potential. Some phytochemicals produced by these species have been separated and identified a few decades ago: hellebrin, deglucohellebrin, 20-hydroxyecdysone and protoanemonin. Lately, many other active compounds have been reported and considered as promising remedies for severe diseases such as cancer, ulcer, diabetes and also for common medical problems such as toothache, eczema, low immunity and arthritis. This paper is an overview of the Helleborus genus focusing on some recentlydiscovered compounds and their potential for finding new drugs and useful biochemicals derived from these species.

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Section: Immunomodulatory Activitymentioning

confidence: 99%

Natural compounds with important medical potential found in Helleborus sp.

Maior

Dobrotă²

2013

Open Life Sciences

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“…Furthermore, we assessed myocardial DCs in a murine model of EAM and analysed the effect of immune modulation through MCS‐18. This substance, which is extracted from the plant helleborus purpurascens, has immunomodulatory properties and has been previously used for preventing experimental autoimmune encephalitis, 34 as well as autoimmune diabetes 35 in animal models. Although not a specific DC inhibitor, it has been shown that MCS‐18 inhibits the production of functionally important DC surface proteins, as well as DC‐mediated T‐cell production 36 …”

Section: Introductionmentioning

confidence: 99%

Characterization of dendritic cells in human and experimental myocarditis

et al. 2020

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Aims Dendritic cells (DCs) are central mediators of adaptive immunity, and there is growing evidence of their role in myocardial inflammatory disease. We hypothesized that plasmacytoid and myeloid DCs are involved in the mechanisms of myocarditis and analysed these two main subtypes in human myocarditis subjects, as well as in a murine model of experimental autoimmune myocarditis (EAM). Methods and results Circulating DCs were analysed by flow cytometry in patients with acute myocarditis, dilated cardiomyopathy, and controls. Myocardial biopsies were immunostained for the presence of DCs and compared with non-diseased controls. In a mouse model of acute myocarditis induced through synthetic cardiac myosine peptide injection, effects of immunomodulation including DC inhibition through MCS-18 versus placebo treatment were tested at the peak of inflammation (Day 21), as well as 1 week later (partial recovery). Circulatory pDCs and mDCs were significantly reduced in myocarditis patients compared with controls (P < 0.01 for both) and remained so even after 6 months of follow-up. Human myocarditis biopsies showed accumulation of pDCs (two-fold CD304+/three-fold CD123+, all P < 0.05) compared with controls. Myocardial pDCs and mDCs accumulated in EAM (P for both <0.0001). MCS-18 treatment reduced pDC levels (P = 0.009), reduced myocardial inflammation (myocarditis score reduction from 2.6 to 1.8, P = 0.026), and improved ejection fraction (P = 0.03) in EAM at Day 21 (peak of inflammation). This effect was not observed during the partial recovery of inflammation on Day 28. Conclusions Circulating DCs are reduced in human myocarditis and accumulate in the inflamed myocardium. MCS-18 treatment reduces DCs in EAM, leading to amelioration of inflammation and left ventricular remodelling during the acute phase of myocarditis. Our data further elucidate the role of DCs and their specific subsets in acute inflammatory cardiomyopathies.

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Mining Chemodiversity From Biodiversity: Pharmacophylogeny of Ranunculaceae Medicinal Plants

Hao¹

2019

Ranunculales Medicinal Plants

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MCS-18, a novel natural plant product prevents autoimmune diabetes

Cited by 10 publications

References 36 publications

Natural compounds with important medical potential found in Helleborus sp.

Natural compounds with important medical potential found in Helleborus sp.

Characterization of dendritic cells in human and experimental myocarditis

Mining Chemodiversity From Biodiversity: Pharmacophylogeny of Ranunculaceae Medicinal Plants

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