MCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer

Bai, Shao-bo; Sun, Yang; Cheng, Ying; Ye, Weiliang; Jiang, Chenchao; Liu, Miao; Q, Ji; Zhang, Bang-Le; Mei, Qibing; Liu, Daozhou; Zhou, Siyuan

doi:10.1186/s12951-021-01115-9

Cited by 12 publications

(5 citation statements)

References 46 publications

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“…The drug release profile was pH-dependent and responsive to the colonic microenvironment, showing a preferential distribution in the colon [ 187 ]. A form of PEC (the modified citrus pectin) that is able to bind galectin-3 and is highly expressed on the membranes of colon cancer cells was exploited to functionalize calcium phosphate NPs [ 188 ] and CS NPs [ 189 ].…”

Section: Resultsmentioning

confidence: 99%

“…The enrichment of colonic flora and specific enzymes plays an important role among the strategies for targeted drug delivery to the gut due to their ability to selectively degrade materials. For this reason, polysaccharides such as pectin, inulin, and some natural gums, which can resist the passage through the gastric tract but are degraded by the intestinal microbiome, were largely used as nanocarriers [ 127 , 184 , 187 , 188 , 189 , 196 , 197 ]. Drug release based on resident bacteria seems to represent a common strategy, although the inflammatory condition related to several gut pathologies, especially when associated with severe diarrhea, can affect the composition of gut microflora [ 340 ].…”

Section: Discussionmentioning

confidence: 99%

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Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

Garbati,

Picco,

Magrassi

et al. 2024

Pharmaceutics

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The intestine is essential for the modulation of nutrient absorption and the removal of waste. Gut pathologies, such as cancer, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and celiac disease, which extensively impact gut functions, are thus critical for human health. Targeted drug delivery is essential to tackle these diseases, improve therapy efficacy, and minimize side effects. Recent strategies have taken advantage of both active and passive nanocarriers, which are designed to protect the drug until it reaches the correct delivery site and to modulate drug release via the use of different physical–chemical strategies. In this systematic review, we present a literature overview of the different nanocarriers used for drug delivery in a set of chronic intestinal pathologies, highlighting the rationale behind the controlled release of intestinal therapies. The overall aim is to provide the reader with useful information on the current approaches for gut targeting in novel therapeutic strategies.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

Garbati,

Picco,

Magrassi

et al. 2024

Pharmaceutics

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“…A pectin gel prepared by mixing a heated pectin solution and a frozen calcium chloride solution induced a 4.8 ± 0.7 haemolysis rate [ 19 ]. Many other studies have previously shown good haemocompatibility for pectin-based biomaterials [ 50 , 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Swelling, Protein Adsorption, and Biocompatibility In Vitro of Gel Beads Prepared from Pectin of Hogweed Heracleum sosnówskyi Manden in Comparison with Gel Beads from Apple Pectin

Popov

Paderin

Khramova

et al. 2022

IJMS

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The study aims to develop gel beads with improved functional properties and biocompatibility from hogweed (HS) pectin. HS4 and AP4 gel beads were prepared from the HS pectin and apple pectin (AP) using gelling with calcium ions. HS4 and AP4 gel beads swelled in PBS in dependence on pH. The swelling degree of HS4 and AP4 gel beads was 191 and 136%, respectively, in PBS at pH 7.4. The hardness of HS4 and AP4 gel beads reduced 8.2 and 60 times, respectively, compared with the initial value after 24 h incubation. Both pectin gel beads swelled less in Hanks’ solution than in PBS and swelled less in Hanks’ solution containing peritoneal macrophages than in cell-free Hanks’ solution. Serum protein adsorption by HS4 and AP4 gel beads was 118 ± 44 and 196 ± 68 μg/cm2 after 24 h of incubation. Both pectin gel beads demonstrated low rates of hemolysis and complement activation. However, HS4 gel beads inhibited the LPS-stimulated secretion of TNF-α and the expression of TLR4 and NF-κB by macrophages, whereas AP4 gel beads stimulated the inflammatory response of macrophages. HS4 gel beads adsorbed 1.3 times more LPS and adhered to 1.6 times more macrophages than AP4 gel beads. Thus, HS pectin gel has advantages over AP gel concerning swelling behavior, protein adsorption, and biocompatibility.

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“…The scanning electron microscope results showed that the nanoparticles had small particle size (<50 nm), and the mixed nanoparticles of heparin/CaCO 3 /CaP loaded with doxorubicin could better solve the drug resistance of tumor cells. Similarly, PSVII carboxymethyl-β-cyclodextrin inclusion compound was successfully encapsulated in colon cancer targeting calcium phosphate nanoparticles (PSVII@MCP-CaP) by using modified citrus pectin as stabilizer agent and colon cancer cell targeting moiety [ 75 ].…”

Section: Application Of Calcium Phosphate Nanocarriersmentioning

confidence: 99%