MC3T3-E1 preosteoblast cell-mediated mineralization of hydroxyapatite by poly-dopamine-functionalized graphene oxide

Cheng, Ju; Liu, Hongyan; Zhao, Bingjiang; Shen, Rong; Liu, Di; Hong, Jinpeng; Wei, Hui; Xi, Pinxian; Chen, Fengjuan; Bai, Decheng

doi:10.1177/0883911515569918

Cited by 43 publications

(32 citation statements)

References 40 publications

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“…5B). A recent study reported that the rGOfunctionalized nanocomposites are able to elevate not only ALP activity but also calcium deposition in MC3T3-E1 preosteoblasts [62]. Therefore, our results suggest that rGO/HAp composites can synergistically facilitate the late stage marker of osteogenic differentiation in the absence of any osteogenic factors.…”

Section: Effects Of Rgo/hap Composites On Calcium Deposition and Matrmentioning

confidence: 73%

Synergistic effects of reduced graphene oxide and hydroxyapatite on osteogenic differentiation of MC3T3-E1 preosteoblasts

Shin

Lee

Jin

et al. 2015

Carbon

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Section: Effects Of Rgo/hap Composites On Calcium Deposition and Matrmentioning

confidence: 73%

Synergistic effects of reduced graphene oxide and hydroxyapatite on osteogenic differentiation of MC3T3-E1 preosteoblasts

Shin

Lee

Jin

et al. 2015

Carbon

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“…Recently, Cheng et al reported a biomimetic mineralization of hydroxyapatite induced by poly‐dopamine‐functionalized reduced graphene oxide (RGO‐PDA). Graphene oxide was first simultaneously reduced and surface functionalized by one‐step oxidative polymerization of dopamine.…”

Section: Main Types Of Research Area For Bone Tissue Engineering Usinmentioning

confidence: 99%

“… Schematic illustration of the preparation of RGO‐PDA hybrid and MC3T3‐E1 cell‐mediated mineralization of HA …”

Section: Main Types Of Research Area For Bone Tissue Engineering Usinmentioning

confidence: 99%

Graphene and its nanostructure derivatives for use in bone tissue engineering: Recent advances

Shadjou

Hasanzadeh

2016

J Biomedical Materials Res

117

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Tissue engineering and regenerative medicine represent areas of increasing interest because of the major progress in cell and organ transplantation, as well as advances in materials science and engineering. Tissue-engineered bone constructs have the potential to alleviate the demand arising from the shortage of suitable autograft and allograft materials for augmenting bone healing. Graphene and its derivatives have attracted much interest for applications in bone tissue engineering. For this purpose, this review focuses on more recent advances in tissue engineering based on graphene-biomaterials from 2013 to May 2015. The purpose of this article was to give a general description of studies of nanostructured graphene derivatives for bone tissue engineering. In this review, we highlight how graphene family nanomaterials are being exploited for bone tissue engineering. Firstly, the main requirements for bone tissue engineering were discussed. Then, the mechanism by which graphene based materials promote new bone formation was explained, following which the current research status of main types of nanostructured scaffolds for bone tissue engineering was reviewed and discussed. In addition, graphenebased bioactive glass, as a potential drug/growth factor carrier, was reviewed which includes the composition-structuredrug delivery relationship and the functional effect on the tissue-stimulation properties. Also, the effect of structural and textural properties of graphene based materials on development of new biomaterials for production of bone implants and bone cements were discussed. Finally, the present review intends to provide the reader an overview of the current state of the graphene based biomaterials in bone tissue engineering, its limitations and hopes as well as the future research trends for this exciting field of science.

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“…Another group showed that GO‐doped poly(lactic‐ co ‐glycolic acid) nanofiber scaffolds through electrospinning increased the adhesion and proliferation of human MSCs . In another study, reduced GO was functionalized with poly‐dopamine to mimic HA mineralization and increased MC3T3‐E1 preosteoblast osteogenesis compared to glass and GO substrates . Adding nanostructured carbon materials to the biodegradable polymer poly(polypropylene fumarate) followed by crosslinking did not change the composites’ cytocompatibilities for NIH‐3T3 fibroblasts and MC3T3‐E1 preosteoblasts .…”

Section: Go As a Scaffold For Bone Regenerationmentioning

confidence: 99%

Graphene oxide as a scaffold for bone regeneration

Holt

Wright

Arnold

et al. 2016

WIREs Nanomed Nanobiotechnol

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Graphene oxide (GO), the oxidized form of graphene, holds great potential as a component of biomedical devices, deriving utility from its ability to support a broad range of chemical functionalities and its exceptional mechanical, electronic, and thermal properties. GO composites can be tuned chemically to be biomimetic, and mechanically to be stiff yet strong. These unique properties make GO-based materials promising candidates as a scaffold for bone regeneration. However, questions still exist as to the compatibility and long-term toxicity of nanocarbon materials. Unlike other nanocarbons, GO is meta-stable, water dispersible, and autodegrades in water on the timescale of months to humic acid-like materials, the degradation products of all organic matter. Thus, GO offers better prospects for biological compatibility over other nanocarbons. Recently, many publications have demonstrated enhanced osteogenic performance of GO-containing composites. Ongoing work toward surface modification or coating strategies could be useful to minimize the inflammatory response and improve compatibility of GO as a component of medical devices. Furthermore, biomimetic modifications could offer mechanical and chemical environments that encourage osteogenesis. So long as care is given to assure their safety, GO-based materials may be poised to become the next generation scaffold for bone regeneration. WIREs Nanomed Nanobiotechnol 2017, 9:e1437. doi: 10.1002/wnan.1437 For further resources related to this article, please visit the WIREs website.

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MC3T3-E1 preosteoblast cell-mediated mineralization of hydroxyapatite by poly-dopamine-functionalized graphene oxide

Cited by 43 publications

References 40 publications

Synergistic effects of reduced graphene oxide and hydroxyapatite on osteogenic differentiation of MC3T3-E1 preosteoblasts

Synergistic effects of reduced graphene oxide and hydroxyapatite on osteogenic differentiation of MC3T3-E1 preosteoblasts

Graphene and its nanostructure derivatives for use in bone tissue engineering: Recent advances

Graphene oxide as a scaffold for bone regeneration

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