May <i>Helicohacter pylori</i> Be Important for Dermatologists

Abstract

Helicohacter pylori, a microaerophilic gram-negative bacterium, is the major cause of gastritis, plays a key role in the etiology of peptic ulcer and is a risk factor for gastric cancer. Although 50% of the population is affected, dermatologists seem to be unaware of the impact H. pylori may have on cutaneous pathology. Among skin diseases, H. pylori has been related so far only with chronic urticaria and rosacea. In rosacea, histology of the stomach mucosa revealed that 84% of 31 patients were H. pylori positive. Twenty percent of them were serologically negative, but, overall, 100% of the 20 patients with both histology and serology were H. pylori positive with either test. The consistency between clinical success with metronidazole and abatement of H. pylori isolates and serology after treatment was an additional evidence suggesting an etiologic relationship between rosacea and H. pylori infection. Rosacea has often been linked with gastrointestinal disturbances. H. pylori, therefore, may link them to the well-known beneficial activity of metronidazole on rosacea lesions. The role of H. pylori is more probable in erythrotic rosacea than in its papulopustular and granulomatous stages. As in Bacillus suhtilis intoxication, a flush-inducing toxin cannot be excluded. Despite the difficulty to find patients accepting bioptic gastroscopies, large case control studies should be done before a causal relationship with urticaria and rosacea is firmly established.

Association of chronic urticaria with Helicobacter Pylori infection in Erbil: A case-control study

“…One possible explanation might be that the immunologic stimulation induced by infection might, through mediator release, causes a non-specific increase of the skin vessel sensitivity to agents increasing vascular permeability. 12 A number of agents might act through this mechanism. As a matter of fact, increased production of interleukin 8 (IL-8), platelet-activating factor (PAF) and leukotrienes (LT) B4 and C4 has been observed in the gastric mucosa of H. Pylori infected patients and these mediators exert evident actions on the skin.…”

Effect of Helicobacter pylori eradication therapy in rosacea patients

“…During these last few years, several studies have suggested a potential relationship between H. pylori and rosacea, as it has been shown that the prevalence of H. pylori infection is higher in patients affected by this condiction when compared to the general population (15). Moreover, it has been described that rosacea symptoms may improve after H. pylori eradication (16).…”

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

“…Acredita-se que mais de um terço dos carcinomas gástri-cos seja atribuído à infecção pelo H. pylori. 26,33,73,100 Outras afecções associadas à infecção pelo H. pylori são linfoma de tecido linfóide associado à mucosa gástrica -MALToma, 105 dispepsia não-ulcerativa, 10,12 doenças coronarianas e cardiovasculares, 90,108,98,107 urticária idiopática crônica, 29,110,129 doenças auto-imunes (púrpura de Henoch-Shönlein, 77,111 trombocitopenia auto-imune, 43 síndrome de Sjögren 37 ) e enxaqueca. 42 Estudos sugerem que existe aumento na incidên-cia de refluxo gastroesofágico (RGE) após erradicação do H. pylori da mucosa gástrica.…”