May Hepatic Steatosis Be Associated with Gynecomastia and Epicardial Fat? A Retrospective Study of 599 Male Patients

Aksoy, Süleyman Hilmi; Aydın, Selami; Yurdaışık, Işıl; Dalkılıç, Orhan

doi:10.4274/bmj.galenos.2022.2022.3-8

Cited by 1 publication

(3 citation statements)

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“…Iacobellis et al reported that epicardial fat thickness is a good indicator of hepatic steatosis in obese patients (25). The results of Aksoy et al's study indicated a strong correlation between epicardial fat thickness and liver density, which is used to determine the presence of hepatic steatosis (r = 0.178, p < 0.001) (10).…”

Section: Discussionmentioning

confidence: 99%

“…In Aksoy et al's study, epicardial fat thickness was correlated with right subareolar tissue thickness (r = 0.085, p = 0.037), left subareolar tissue thickness (r = 0.101, p = 0.014) and fat tissue thickness Right retro-areolar (r = 0.148, p > 0.001) had a signi cant relationship. However, the underlying mechanisms of these correlations have not yet been clari ed (10).…”

Section: Discussionmentioning

confidence: 99%

“…Patients with hepatic steatosis often have high estrogen and low testosterone levels, which clinically manifest as testicular atrophy, palmar erythema, and gynecomastia (9). However, the exact mechanism through which hepatic steatosis can contribute to gynecomastia has not yet been clari ed (10).…”

Section: Introductionmentioning

confidence: 99%

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Association of gynecomastia and fatty liver and epicardial fat in COVID-19 patients

Livani

Fatemi

Aqerkakli

et al. 2023

Preprint

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Objectives: We aimed to determine the association between gynecomastia, hepatic steatosis through liver density and epicardial fat thickness in CT-scans of COVID-19 patients. Methods and Materials: In this descriptive-analytical cross-sectional study, Gynecomastia, fatty liver and epicardial fat were measured using CT-scan. The collected data were analyzed using Graphpad Prism 9 software. A significance level of less than 0.05 was considered. Results: Among 341 men hospitalized with COVID-19 infection, 35 (10%) were admitted to intensive care unit (ICU) and 62 (18%) died. The prevalence of gynecomastia and fatty liver was 35% and 20% respectively. Patients' age had a direct positive correlation with mortality (r=0.21, P<0.001) and epicardial fat (r=0.28, P<0.001). Bilateral gynecomastia was not associated with mortality or ICU admission, the prevalence of fatty liver, and the amount of epicardial and retro-areolar fat. However, right-sided gynecomastia was associated with the prevalence of fatty liver (r=0.11 and P=0.05) and left-sided gynecomastia was associated with epicardial fat (r=0.14 and P=0.01). In this study, the prevalence of fatty liver was positively correlated to the amount of epicardial fat (r = 0.12, P = 0.02) and retro-areolar fat (r = 0.34, P < 0.001). Conclusion: Bilateral gynecomastia was not associated with mortality or ICU admission, prevalence of fatty liver, and epicardial and retro-areolar fat volume. But right-sided gynecomastia was associated with the prevalence of fatty liver and left sided gynecomastia was associated with epicardial fat. The amount of retro-areolar fat was recognized as a risk factor for the death of patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%