Maximum urine concentration Early means of identifying patients with reflux who may require surgery

Growth of the Kidney following Unilateral Antireflux Surgery

“…Evidence for such metabolic changes due to alteration in tubular function in the human are infrequent [19,20,[27][28][29] and have been complicated in some cases due to coexistent infection with acute or chronic pyelonephritis [27] , Other workers have shown an improvement in renal-concentrating ability following successful antireflux surgery [19]; in 15 of 27 children studied pre-operatively and 1 year post-operatively there was an increase in the maximal urinary osmolality of 80 osmol/kg. Urinary Infection.…”

“…Factors which may be relevant include urinary infection, a negative cal orie balance [14], hormonal changes [15][16][17][18] and loss of renal concentrating ability [19,20], Renal Concentrating Ability. Another explanation to account for alterations in renal growth before and after curative surgical treatment is based on alterations in renal tubular function.…”

Insuficiencia renal crónica congénita y reflujo vesicoureteral de quinto grado bilateral

“…La nefropatía médica que acompaña a las cicatrices renales puede caracterizarse por hiperfiltración, defectos en la concentración de orina, proteiunia, microalbuminuria, acidosis tubular renal y aumento de la excreción fraccionada de sodio y magnesio (63,64,65). A pesar de que es probable que todos estos parámetros sean el resultado directo de la lesión tubular y parenquimatosa o de la malformación, se informaron defectos en la concentración de la orina y aumento de la concentración de enzimas tubulares en presencia de reflujo estéril, independientemente de los antecedentes de infección (66,67).…”