Maximizing the reproductive performances of anestrus dairy buffalo cows using GnRH analogue-loaded chitosan nanoparticles during the low breeding season

Gallab, Rezk S.; Hassanein, Eman M.; Rashad, Amr M.A.; El-Shereif, Abdelghany A

doi:10.1016/j.anireprosci.2022.107044

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…GnRH is synthesized in the hypothalamus of vertebrates and is a key endocrine regulator that drives the hypothalamus–pituitary–gonad axis and ultimately activates the reproductive endocrine network. In addition to being involved in the regulation of gonadotropins, sexual behavior, olfactory signaling, fetal growth and development, and the formation and function of the immune system [ 43 ], GnRH can also improve the spermatogenic ability and sperm quality of bulls, induce estrus and ovulation in cows, and enhance the possibility of conception [ 44 , 45 ]. Testosterone was significantly downregulated, suggesting that the DDGS diet may affect the metabolism of GnRH and subsequently the endocrine regulation of the body, thereby modulating growth and enhancing the reproductive performance and development of the fetus.…”

Section: Discussionmentioning

confidence: 99%

Plasma Metabolomic Profiling after Feeding Dried Distiller’s Grains with Solubles in Different Cattle Breeds

Zhang

et al. 2023

IJMS

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Dried distiller’s grains with solubles (DDGS) are rich in nutrients and can enhance animals’ growth and immunity. However, there are few reports on the effects of a diet of DDGS on plasma metabolism and the related action pathways in domestic animals. In this study, groups of Guanling yellow cattle (GY) and Guanling crossbred cattle (GC) having a basal diet served as the control groups (GY-CG and GC-CG), and DDGS replacing 25% of the diet of GY and GC served as the replacement groups (GY-RG and GC-RG), with three cattle in each group. Plasma samples were prepared for metabolomic analysis. Based on multivariate statistical and univariate analyses, differential metabolites and metabolic pathways were explored. Twenty-nine significantly different metabolites (p < 0.05) were screened in GY-RG compared with those in GY-CG and were found to be enriched in the metabolic pathways, including choline metabolism in cancer, linolenic acid metabolism, and amino acid metabolism. Nine metabolites showed significant differences (p < 0.05) between GC-RG and GC-CG and were mainly distributed in the metabolic pathways of choline metabolism in cancer, glycerophospholipid metabolism, prostate cancer metabolism, and gonadotropin-releasing hormone (GnRH) secretion. These results suggest that a DDGS diet may promote healthy growth and development of experimental cattle by modulating these metabolic pathways. Our findings not only shed light on the nutritional effects of the DDGS diet and its underlying mechanisms related to metabolism but also provide scientific reference for the feed utilization of DDGS.

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Section: Discussionmentioning

confidence: 99%

Plasma Metabolomic Profiling after Feeding Dried Distiller’s Grains with Solubles in Different Cattle Breeds

Zhang

et al. 2023

IJMS

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“…Similarly, in rabbits, applying chitosan-dextran sulfate GnRH (buserelin) nanoparticles intravaginally with seminal doses for ovulation induction reduced the conventional GnRH agonist dose without compromising reproductive performance variables [ 21 ]. During the low-breeding season in buffalo cows, where reproduction is typically reduced, the administration of nano-GnRH analog (ovurelin) as a modified ovsynch treatment regimen led to a 50% reduction in the conventional dose, with beneficial effects occurring on fertility and ovarian activity in anestrous cows [ 131 ]. Applying the same methodology in goats, developing a nano-GnRH analog (gonadorelin) allowed for a reduction of hormonal dose by up to 75%, maintaining fertility and prolificacy without adverse effects [ 132 ].…”

Section: Gnrh Nano-drug Delivery Systemmentioning

confidence: 99%

Gonadotropin-Releasing Hormone (GnRH) and Its Agonists in Bovine Reproduction II: Diverse Applications during Insemination, Post-Insemination, Pregnancy, and Postpartum Periods

Hassanein,

Szelényi,

Szenci

2024

Animals

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The administration of GnRH and its agonists benefits various aspects of bovine reproductive programs, encompassing physiological stages such as estrous synchronization, post-insemination, pregnancy, and the postpartum period. The positive impact of GnRH administration in overcoming challenges like repeat breeder cows, early embryonic loss prevention, and the management of cystic ovarian disease (COD) is thoroughly surveyed. Furthermore, this review focuses on the significance of GnRH administration during the postpartum period, its role in ovulation induction, and how it enhances the productivity of embryo transfer (ET) programs. An emerging feature of this field is introduced, focusing on nano-drug delivery systems for GnRH agonists, and the potential benefits that may arise from such advancements are highlighted. While this review offers valuable insights into various applications of GnRH in bovine reproduction, it emphasizes the crucial need for further research and development in this field to advance reproductive efficiency and health management in dairy cattle.

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“…One of the important factors that can affect reproductive function is the nutrition (Nurfathaya et al 2019). A combined strategy of improvement in environment, nutrition and management is pre-requisite for hormonal manipulation in order to improve productivity of buffaloes during the summer season (Vijayalakshmy et al 2020;Abulaiti et al 2022;Gallab et al 2022).…”

Section: Onset Of Estrusmentioning

confidence: 99%

Reproductive Performance of Swamp Buffalo with Various Dosages of Gonadotropin-Releasing Hormone (GnRH)

2023

Int J Vet Sci

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This study aims to determine the reproductive performance of Swamp buffalo with various dosage of gonadotropinreleasing hormone (GnRH). The study subjects were Swamp buffaloes (n=16) with an average age of about 5-6 years, a normal estrus cycle, non-pregnant, and had no history of reproductive disease. Estrus synchronization was performed with an injection of 5mL PGF2α hormone. GnRH was injected on the 8th day with various doses (A=without GnRH injection, B=200mg/2mL, C=300mg/3mL, and D=400mg/4mL). Variables observed were superovulation response, the success of artificial insemination, and speed and intensity of onset of estrus in Swamp buffalo. The results showed that the average superovulation response was 81.25%. The success rate of AI was on average 75% with the highest success rate (100%) with C treatment (300g GnRH + 5mL PGF2α). Swamp buffaloes that have been treated have onset of estrus ranging from 72-81hrs and high intensity of estrus. The administration of GnRH 300mg (group C) and 400mg (group D) gave the best superovulation response (100%) and a 100% pregnancy with the administration of 300mg of GnRH (group C). Administration of GnRH 200mg (group B) showed the fastest estrus onset and all treated buffaloes showed high estrus intensity with a score of +++.

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Maximizing the reproductive performances of anestrus dairy buffalo cows using GnRH analogue-loaded chitosan nanoparticles during the low breeding season

Cited by 6 publications

References 37 publications

Plasma Metabolomic Profiling after Feeding Dried Distiller’s Grains with Solubles in Different Cattle Breeds

Plasma Metabolomic Profiling after Feeding Dried Distiller’s Grains with Solubles in Different Cattle Breeds

Gonadotropin-Releasing Hormone (GnRH) and Its Agonists in Bovine Reproduction II: Diverse Applications during Insemination, Post-Insemination, Pregnancy, and Postpartum Periods

Reproductive Performance of Swamp Buffalo with Various Dosages of Gonadotropin-Releasing Hormone (GnRH)

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