“…The more complex the study protocol, the higher the compliance and retention [16,22,29,33,34,46,48,53,[56][57][58][61][62][63][64]66,71,72,72,81,82,112,114,117,119,124,125,141,147,149,152,172,180,187,189] 36/182 Frequency of follow-up T 1 Drug / Product Patients who are dissatisfied with drug/product (taste, smell, etc) have worse compliance and retention [14,17,18,22,31,54,57,64,71,74,78,83,87,92,97,…”