Maximizing muscle protein anabolism: the role of protein quality

Tang, Jin; Phillips, Stuart M.

doi:10.1097/mco.0b013e32831cef75

Cited by 157 publications

(101 citation statements)

References 86 publications

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“…Besides soy isoflavones, other soy constituents such as protein may affect muscle mass [29]. Several studies have indicated that high-quality proteins such as soy can support muscle protein synthesis [30][31][32]. Isoflavones also appear to work in conjunction with soy protein to exert antiatherogenic and antiosteorotic effects, and other soy constituents may also mediate the loss of muscle mass through their antioxidant activities [33].…”

Section: Discussionmentioning

confidence: 99%

Legumes and soy products consumption and functional disability in older women

Kim

Lee

2011

Maturitas

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Section: Discussionmentioning

confidence: 99%

Legumes and soy products consumption and functional disability in older women

Kim

Lee

2011

Maturitas

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“…These processes result in atrophy and loss of muscle mass. However, this theory was disputed by reports showing that essential amino acids (Drummond et al, 2008) or, however, high quality proteins sufficient ingestion, increase the muscle protein synthesis equally in both young and old subjects (Tang and Phillips, 2009).…”

Section: Introductionmentioning

confidence: 99%

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

Pietrangelo¹,

Puglielli²,

Mancinelli³

et al. 2009

Experimental Gerontology

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ular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation. Experimental Gerontology, Elsevier, 2009, 44 (8) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT AbstractSarcopenia is the age-related loss of muscle mass, strength and function. Human muscle proteins are synthesized at a slower rate in the elderly than in young adults, leading to atrophy and muscle mass loss with a decline in the functional capability. Additionally, aging is accompanied by a decrease in the ability of muscle tissue to regenerate following injury or overuse due to the impairment of intervening satellite cells, in which we previously reported oxidative damage evidences. The aim of the present study was to determine the effects of aging on myoblasts and myotubes obtained from human skeletal muscle, and characterize the transcriptional profile as molecular expression patterns in relation to age-dependent modifications in their regenerative capacity. Our data show that the failure to differentiate does not depend on reduced myogenic cell number, but difficulty to complete the differentiation program. Data reported here suggested the following findings: i) oxidative damage accumulation in molecular substrates, probably due to impaired antioxidant activity and insufficient repair capability, ii) limited capability of elderly myoblasts to execute a complete differentiation program; restricted fusion, possibly due to altered cytoskeleton turnover and extracellular matrix degradation, and iii) activation of atrophy mechanism by activation of a specific FOXO-dependent program.

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“…Interestingly, whey proteins resulted in higher muscle protein synthesis as compared with soy proteins (Philips et al 2009). This has been attributed to the fact that soy proteins are more preferentially directed toward splanchnic synthesis than whey proteins are (Tang & Phillips 2009). In addition, the improvement of insulin action in muscle is crucial for maintaining a positive balance between protein synthesis and degradation as well as for slowing down sarcopenia and frailty syndrome (Fulop et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Milk-soluble formula increases food intake and reduces Il6 expression in elderly rat hypothalami

Hamouda¹,

Delplanque²,

Benomar³

et al. 2015

Journal of Endocrinology

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Malnutrition in the elderly is accompanied by several metabolic dysfunctions, especially alterations in energy homeostasis regulation and a loss of insulin responsiveness. Nutritional recommendations aim to enrich food with high protein and energy supplements, and protein composition and lipid quality have been widely studied. Despite the numerous studies that have examined attempts to overcome malnutrition in the elderly through such nutritional supplementation, it is still necessary to study the effects of a combination of protein, lipids, and vitamin D (VitD). This can be done in animal models of elderly malnutrition. In the present study, we investigated the effects of several diet formulae on insulin responsiveness, inflammation, and the hypothalamic expression of key genes that are involved in energy homeostasis control. To mimic elderly malnutrition in humans, elderly Wistar rats were food restricted (R, K50%) for 12 weeks and then refed for 4 weeks with one of four different isocaloric diets: a control diet; a diet where milk soluble protein (MSP) replaced casein; a blend of milk fat, rapeseed, and DHA (MRD); or a full formula (FF) diet that combined MSP and a blend of MRD (FF). All of the refeeding diets contained VitD. We concluded that: i) food restriction led to the upregulation of insulin receptor in liver and adipose tissue accompanied by increased Tnfa in the hypothalamus; ii) in all of the refed groups, refeeding led to similar body weight gain during the refeeding period; and iii) refeeding with MSP and MRD diets induced higher food intake on the fourth week of refeeding, and this increase was associated with reduced hypothalamic interleukin 6 expression.

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Maximizing muscle protein anabolism: the role of protein quality

Abstract: Recent evidence suggests that consumption of different proteins can affect the amplitude and possibly duration of MPS increases after feeding and this effect interacts and is possibly accentuated with resistance exercise.

Cited by 157 publications

References 86 publications

Legumes and soy products consumption and functional disability in older women

Legumes and soy products consumption and functional disability in older women

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

Milk-soluble formula increases food intake and reduces Il6 expression in elderly rat hypothalami

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