Maximal Exercise Testing of Men with Prostate Cancer Being Treated with Androgen Deprivation Therapy

Wall, Bradley A; Galvão, Daniel A.; Fatehee, Naeem; Taaffe, Dennis R.; Spry, Nigel; Joseph, David; Newton, Robert U.

doi:10.1249/mss.0000000000000353

Cited by 20 publications

(18 citation statements)

References 34 publications

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“…To examine cardiovascular adaptations to exercise, oxygen consumption (VO 2 ) and heart rate (HR) responses were measured during the first 2 stages of a modified Bruce Treadmill protocol. 13 These stages correspond to velocities of 2.7 and 4.0 km/h at gradients of 10% and 12%, respectively. Oxygen uptake was measured through indirect calorimetry (Parvo Metabolic Measuring System, Sandy, UT).…”

Section: Physical and Physiological Measuresmentioning

confidence: 97%

Exercise Improves Physical Function and Mental Health of Brain Cancer Survivors

et al. 2015

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Background Malignant brain tumors are unpredictable and incurable, with 5-year survival rates less than 30%. The poor prognosis combined with intensive treatment necessitates the inclusion of complementary and supportive therapies that optimize quality of life and reduce treatment-related declines in health. Exercise therapy has been shown to be beneficial in other cancer populations, but no evidence is available for brain cancer survivors. Therefore, we report results from 2 preliminary cases. Methods Two female patients diagnosed with glioblastoma multiforme and oligodendroglioma participated in a structured and supervised 12-week exercise program. The program consisted of two 1-hour resistance and aerobic exercise sessions per week and additional self-managed aerobic sessions. Outcome measures of strength, cardiovascular fitness, and several psychological indicators (depression, anxiety, and quality of life) were recorded at baseline, after 6 weeks and at the conclusion of the intervention. Results Exercise was well tolerated; both participants completed all 24 sessions and the home-based component with no adverse effects. Objective outcome measures displayed positive responses relating to reduced morbidity. Similar positive responses were found for psychological outcomes. Scores on the Hospital Anxiety and Depression Scale showed clinically meaningful improvements in depression and total distress. Conclusion These findings provide initial evidence that, despite the difficulties associated with brain cancer treatment and survivorship, exercise may be safe and beneficial and should be considered in the overall management of patients with brain cancer.

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Section: Physical and Physiological Measuresmentioning

confidence: 97%

Exercise Improves Physical Function and Mental Health of Brain Cancer Survivors

et al. 2015

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“…In the interim, in men undergoing ADT, the monitoring and management of cardiovascular risk factors (hyperglycemia, hyperlipidemia, hypertension, and obesity) should be seen as an integral part of patient management. 74 …”

Section: Basic Physiologymentioning

confidence: 99%

“… 75 A further prospective randomized trial of dietary and exercise intervention is underway, 76 but while these important studies may yield benefits to prostate cancer patients, they are unlikely to be able to demonstrate whether such interventions are capable of ameliorating the risks associated with ADT. 74 – 77 What is clear is that in the general population, cardiac rehabilitation programs that primarily utilize exercise produce compelling and consistent clinical results in men with preexisting cardiovascular disease. Randomized trials have shown that cardiac rehabilitation reduces the probability of suffering additional cardiac events and is associated with a broad range of benefits, including reduced mortality.…”

Section: Basic Physiologymentioning

confidence: 99%

Cardiovascular effects of hormone therapy for prostate cancer

Lester¹,

Mason²

2015

DHPS

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Androgen deprivation therapy (ADT) has been the mainstay of treatment for advanced prostate cancer for decades, and has been shown to control disease and improve symptoms. In addition, for men with high-risk localized or locally advanced prostate cancer, short-course ADT in combination with radiotherapy improves survival. There is evidence that ADT increases cardiovascular risk, particularly in men with preexisting cardiovascular disease. This increased risk may apply even with short-course ADT. In an individual patient, the benefits of ADT should be balanced against the risk, and patients who require ADT should have risk factors for cardiovascular disease optimized. There is some evidence to suggest that more contemporary methods of delivering ADT may reduce cardiovascular risk.

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“…A total of 60 patients had been <3 months with ADT (acute), while 52 had been on ADT for >3 months (chronic). Average VO 2 max values were 24.7 ± 6.0 mL/kg/min . Caffeine appears to improve exercise tolerance through improved performance without subsequently increasing fatigue or the perception of effort.…”

Section: Exercise Promotion In Prostate Cancer Patientsmentioning

confidence: 92%

“…Thus, interventions to improve exercise motivation and adherence are of great concern. Wall et al evaluated 112 patients with prostate cancer undergoing ADT with a maximal stress test (Bruce protocol). A total of 60 patients had been <3 months with ADT (acute), while 52 had been on ADT for >3 months (chronic).…”

Section: Exercise Promotion In Prostate Cancer Patientsmentioning

confidence: 99%

Exercise and prostate cancer: From basic science to clinical applications

et al. 2018

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Prostate cancer (PCa) is a disease of increasing medical significance worldwide. In developed countries, PCa is the most common non-skin cancer in men, and one of the leading causes of cancer-related deaths. Exercise is one of the environmental factors that have been shown to influence cancer risk. Moreover, systemic reviews and meta-analysis have suggested that total physical activity is related to a decrease in the risk of developing PCa. In addition, epidemiological studies have shown that exercise, after diagnosis, has benefits regarding PCa development, and positive outcome in patients under treatment. The standard treatment for locally advanced or metastatic PCa is Androgen deprivation therapy (ADT). ADT produces diverse side effects, including loss of libido, changes in body composition (increase abdominal fat), and reduced muscle mass, and muscle tone. Analysis of numerous research publications showed that aerobic and/or resistance training improve patient's physical condition, such us, cardiorespiratory fitness, muscle strength, physical function, body composition, and fatigue. Therefore, exercise might counteract several ADT treatment-induced side effects. In addition of the aforementioned benefits, epidemiological, and in vitro studies have shown that exercise might decrease PCa development. Thus, physical activity might attenuate the risk of PCa and supervised exercise intervention might improve deleterious effects of cancer treatment, such as ADT side effects. This review article provides evidence indicating that exercise could complement, and potentiate, the current standard treatments for advanced PCa, probably by creating an unfavorable microenvironment that can negatively affect tumor development, and progression.

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Maximal Exercise Testing of Men with Prostate Cancer Being Treated with Androgen Deprivation Therapy

Cited by 20 publications

References 34 publications

Exercise Improves Physical Function and Mental Health of Brain Cancer Survivors

Exercise Improves Physical Function and Mental Health of Brain Cancer Survivors

Cardiovascular effects of hormone therapy for prostate cancer

Exercise and prostate cancer: From basic science to clinical applications

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