Maximal exercise capacity and peripheral skeletal muscle function following lung transplantation

Lands, Larry C.; Smountas, Argyrios A.; Mesiano, Giulia; Brosseau, Lucie; Shennib, Hani; Charbonneau, Marc; Gauthier, R

doi:10.1016/s1053-2498(98)00027-8

Cited by 97 publications

(80 citation statements)

References 28 publications

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“…[7][8][9] In addition, these patients are subject to the inherent risks of ECMO, including renal dysfunction, infection, and bleeding. 10 Several centers use ambulatory ECMO to rehabilitate patients to mitigate deconditioning in an attempt to improve outcomes in these critically ill patients.…”

Section: See the Related Editorial On Page 117mentioning

confidence: 99%

Economic Outcomes of Extracorporeal Membrane Oxygenation With and Without Ambulation as a Bridge to Lung Transplantation

et al. 2015

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Section: See the Related Editorial On Page 117mentioning

confidence: 99%

Economic Outcomes of Extracorporeal Membrane Oxygenation With and Without Ambulation as a Bridge to Lung Transplantation

et al. 2015

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“…5 Reduced total leg strength and work capacity were noted in another group of patients, most of whom were Ͼ18 months post-LTx. 6 Reduced oxygen utilization by the vastus lateralis muscle was demonstrated after LTx by 31-phosphorus ( 31 P)-magnetic resonance spectroscopy and by optical near-infrared spectroscopy. 7,8 Skeletal muscle biopsies from the quadriceps exhibited lower activity of the oxidative enzymes, lower proportion of type 1 (fatigue-resistant) fibers, higher lactate concentration, low intramyocyte pH, and reduced adenosine triphosphate (ATP) content.…”

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confidence: 99%

Limiting Factors of Exercise Performance 1 Year After Lung Transplantation

Reinsma

Hacken

Grevink

et al. 2006

The Journal of Heart and Lung Transplantation

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Background: After lung transplantation (LTx) exercise capacity frequently remains limited, despite significantly improved pulmonary function. The aim of this study was to evaluate maximal exercise capacity and peripheral muscle force before and 1 year after LTx, and to determine whether peripheral muscle force and lactate threshold (LT) limit exercise capacity 1 year after LTx. Methods:Twenty-five subjects (mean age 43 years, 8 women and 17 men, 4 single-lung transplantations) were included in the study. Measurements included maximal exercise capacity, lactate threshold (symptom-limited bicycle ergometer test) and muscle force test (hand-held dynamometer) were performed before and 1 year after LTx. Results:Before LTx, all patients showed severe exercise intolerance (mean Ϯ SD): work capacity (W peak ), 11.6 Ϯ 18 W; peak oxygen uptake (VO 2 ), 8.6 Ϯ 3.6 ml/min/kg. After LTx, exercise capacity improved significantly: W peak , 69 Ϯ 27 W (p Ͻ 0.001); peak VO 2 , 15.7 Ϯ 4.3 ml/min/kg (p Ͻ 0.001). Ventilatory factors did not appear to limit exercise capacity. Quadriceps muscle force pre-vs post-LTx was: 248 Ϯ 73 N vs 281 Ϯ 68 N (p Ͻ 0.05). Post-LTx, a significant correlation was found between LT and exercise capacity (r ϭ 0.76, p Ͻ 0.001), between muscle force and exercise capacity (r ϭ 0.41, p Ͻ 0.05) and between the LT and muscle force (r ϭ 0.53, p Ͻ 0.01). Conclusions:The occurrence of an early and pathologic LT and peripheral muscle weakness contributes to the limitation of exercise capacity and reflects a peripheral deficit post-LTx.

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“…This skeletal muscle dysfunction shows clinical relevance because it is related to an increased need for medical assistance and decreased survival of COPD patients [8][9][10][11]. In addition, a limited improvement in exercise capacity has been demonstrated when COPD patients receive a pulmonary or combined heart-lung transplant [12][13][14].…”

mentioning

confidence: 99%

Relevance of assessing quadriceps endurance in patients with COPD

Coronell

Orozco-Levi

Mendez³

et al. 2004

European Respiratory Journal

173

135

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The aims of this study were to investigate whether the impairment in endurance of limb muscles is a general finding in chronic obstructive pulmonary disease (COPD) patients, affecting even those with mild-to-moderate disease or relatively normal physical activity. In addition, this study aimed to determine the physiopathology of exhaustion in local endurance tests and whether the reduction in quadriceps endurance can be predicted from muscle strength measurements.A total of 75 volunteers were assigned to one of two groups according to pulmonary function tests: COPD patients or healthy age-matched controls. Functional assessment included both quadriceps strength (maximum voluntary contraction (QMVC)), and quadriceps endurance (contractions against a load equivalent to 10% QMVC until task failure or for up to a limiting time of 30 min (QTlim)).COPD patients showed a decrease of y43% in QMVC and y77% in QTlim compared with controls. Task failure occurred only in COPD patients and was due to muscle fatigue, since limiting symptoms were associated with a decrease in the median frequency of quadriceps electromyographical signal and a reversible decrease in QMVC. The impairment in skeletal muscle endurance was present even in patients with mild-tomoderate airflow obstruction and individuals with relatively normal physical activity, and was irrespective of lung function variables, anthropometrical data or quadriceps strength.Peripheral muscle endurance was impaired in chronic obstructive pulmonary disease patients, even in those with relatively normal physical activity and mild-to-moderate airflow obstruction. This impairment associated with an early onset of muscle fatigue and could not be predicted from the severity of the disease or the reduction in quadriceps strength. Eur Respir J 2004; 24: 129-136.

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Maximal exercise capacity and peripheral skeletal muscle function following lung transplantation

Cited by 97 publications

References 28 publications

Economic Outcomes of Extracorporeal Membrane Oxygenation With and Without Ambulation as a Bridge to Lung Transplantation

Economic Outcomes of Extracorporeal Membrane Oxygenation With and Without Ambulation as a Bridge to Lung Transplantation

Limiting Factors of Exercise Performance 1 Year After Lung Transplantation

Relevance of assessing quadriceps endurance in patients with COPD

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