Maxillary sinus floor elevation with a tissue-engineered bone composite of deciduous tooth stem cells and calcium phosphate cement in goats

Zhao, Wei; Lu, Jiayu; Hao, Yong-ming; Cao, Chunhua; Zou, Derong

doi:10.1002/term.1867

Cited by 14 publications

(6 citation statements)

References 44 publications

(53 reference statements)

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“…This results in the production of a large amount of ALP into the blood, which increases the ALP content in the blood. OCN can be combined with Ca and hydroxyapatite to promote bone mineralization (Zhao, Lu, Hao, Cao, & Zou, ). Our study showed that most of the osteoblasts in the bone marrow of piglets are at maturity, and their mineralization is obvious at a Ca/AP of 2:1.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary calcium to available phosphorus ratios on bone metabolism and osteoclast activity of the OPG /RANK/RANKL signalling pathway in piglets

Zhao

Sun

2019

Animal Physiology Nutrition

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Hydroxyapatite, a mineral form of calcium (Ca) and phosphorus (P) that gives bones their rigidity, is the major and essential component of bones and teeth in the human and animal body. A suitable ratio of Ca and P is vital for bone growth. The aim of this study was to explore the effects of dietary calcium to available phosphorus ratios (Ca/AP) on bone metabolism and osteoclast activity of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) signalling pathway in piglets. At days 15 and 29, the piglets were assessed for growth performance, blood indicators, cytokines and the OPG/RANK/RANKL signalling pathway. Our results showed that piglets fed a dietary Ca/AP ratio of 2:1 increases growth performance and regulates blood indicators and cytokines (parathyroid hormone (PTH), calcitonin (CT), vitamin D3 (VD3), insulin‐like growth factor‐1 (IGF‐1), transforming growth factor‐β (TGF‐β), interleukin‐1 (IL‐1), interleukin‐6 (IL‐6), carboxyterminal propeptide of type I procollagen (PICP), tartrate‐resistant acid phosphatase (TRACP), alkaline phosphatase (ALP) and osteocalcin (OCN) content). We also demonstrated that this ratio affects hormone secretion and further bone metabolism through the OPG/RANK/RANKL signalling pathway of osteoclasts. These results indicate that a suitable dietary Ca/AP ratio is vital for bone growth and reduce the incidence of bone diseases such as osteoporosis, providing a practical basis for the raising of piglets.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary calcium to available phosphorus ratios on bone metabolism and osteoclast activity of the OPG /RANK/RANKL signalling pathway in piglets

Zhao

Sun

2019

Animal Physiology Nutrition

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“…Regarding dental regeneration, both sheep and goat are reasonable candidates as animal models, although not widely used for this field. Nonetheless, various studies have used bone grafting techniques associated with dental stem cell therapy, such as dental pulp stem cells [139,145,146].…”

Section: Osteoarticular Systemmentioning

confidence: 99%

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives

Alvites

Branquinho

Sousa

et al. 2021

Biology

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Medical and translational scientific research requires the use of animal models as an initial approach to the study of new therapies and treatments, but when the objective is an exploration of translational potentialities, classical models fail to adequately mimic problems in humans. Among the larger animal models that have been explored more intensely in recent decades, small ruminants, namely sheep and goats, have emerged as excellent options. The main advantages associated to the use of these animals in research works are related to their anatomy and dimensions, larger than conventional laboratory animals, but very similar to those of humans in most physiological systems, in addition to their low maintenance and feeding costs, tendency to be docile, long life expectancies and few ethical complications raised in society. The most obvious disadvantages are the significant differences in some systems such as the gastrointestinal, and the reduced amount of data that limits the comparison between works and the validation of the characterization essays. Despite everything, recently these species have been increasingly used as animal models for diseases in different systems, and the results obtained open doors for their more frequent and advantageous use in the future. The purpose of this review is to summarize the general principles related to the use of small ruminants as animal models, with a focus on regenerative medicine, to group the most relevant works and results published recently and to highlight the potentials for the near future in medical research.

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“…Regarding dental regeneration, both sheep and goat are fare candidates as animal models, although not widely used for this field. Nonetheless, various studies have been applying bone grafting techniques associated with dental stem cell therapy, like dental pulp stem cells (133,139,140).…”

Section: Osteoarticular Systemmentioning

confidence: 99%

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives.

Alvites¹,

Branquinho²,

Sousa³

et al. 2021

Preprint

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Medical and translational scientific research requires the use of animal models as an initial approach to the study of new therapies and treatments, but when the objective is an exploration of translational potentialities, classical models fail to adequately mimic problems in humans. Among the larger animal models that have been explored more intensely in recent decades, small ruminants, namely sheep and goats, have emerged as excellent options. The main advantages associated to the use of these animals in research works are related to their anatomy and dimensions very similar to those of humans in most physiological systems, in addition to their low maintenance and feeding costs, tendency to be docile, long life expectancies and few ethical complications raised in society. The most obvious disadvantages are the significant differences in some systems such as the gastrointestinal, and the reduced amount of data that limits the comparison between works and the validation of the characterization essays. Despite everything, recently these species have been increasingly used as animal models for diseases in different systems, and the results obtained open doors for their more frequent and advantageous use in the future. The purpose of this review is to summarize the general principles related to the use of small ruminants as animal models, with focus on regenerative medicine, to group the most relevant works and results published recently and to highlight the potentials for the near future in medical research.

show abstract

Maxillary sinus floor elevation with a tissue-engineered bone composite of deciduous tooth stem cells and calcium phosphate cement in goats

Cited by 14 publications

References 44 publications

Effects of dietary calcium to available phosphorus ratios on bone metabolism and osteoclast activity of the OPG /RANK/RANKL signalling pathway in piglets

Effects of dietary calcium to available phosphorus ratios on bone metabolism and osteoclast activity of the OPG /RANK/RANKL signalling pathway in piglets

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives.

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