Maxillary Sinus Elevation Surgery with ChronOS and Autogenous Bone Graft: Immunohistochemical Assessment of RUNX2, VEGF, TRAP, and Osteocalcin

Pereira, Rodrigo dos Santos; Boos, Fernanda Brasil Jorge Daura; Gorla, Luis Fernado; Garcia, Idelmo Rangel; Okamoto, Roberta; Hochuli‐Vieira, Eduardo

doi:10.11607/prd.2606

Cited by 6 publications

(3 citation statements)

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“…Runx is necessary for the correct structure of osteoblast cells. It promotes bone mineralisation, osteoblast proliferation and induces mesenchymal cell differentiation into immature osteoblasts until the final stage of the process in which maturity of osteoblasts is inhibited (Dos Santos Pereira et al, 2017). Our results indicated that there was no statistically significant difference between the CLP group and the control group, but the numbers of Runx2 positive structures in the bone and cartilage tissue was low, indicating reduced mineralisation potential of the hard tissue.…”

Section: Discussionmentioning

confidence: 63%

“…The BMPs and the FGFs regulate transcription of Runx2. Runx2 also induces mesenchymal cell differentiation into immature osteoblasts until the final stage of the process during which maturity of the osteoblasts are inhibited (Komori, 2010;Dos Santos Pereira et al, 2017). A study on Chinese patients showed that normal distribution of the Runx2 also might be a reason for cranial dysplasia due to the mutation in the Runt domain, which leads the impaired transaction activities of Runx2 (Zhang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Appearance and Distribution of Tissue Remodellation Factors in the Hard Tissue of Patients Affected by Cleft Lip Palate

Buile

Pilmane

Akota

2020

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Bone repair after surgical intervention on cleft lip palate (CLP) depends on the coordinated action of multiple tissue regeneration factors. We determined the relative number and appearance of tissue factors: matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase-2 (TIMP-2), bone morphogenetic protein 2/4 (BMP 2/4), transforming growth factor beta (TGF-ß), Wnt3a protein (Wnt3a), Runt-related transcription factor 2 (Runx2), basic fibroblast growth factor (bFGF) and osteoprotegerin in hard tissue of CLP patients during first time surgical intervention. Fourty-three CLP patients with 24 bone and 36 cartilage samples were involved. Immunohistochemistry was used to assess the levels of tissue factors and the semi-quantitative census method was used for quantification of immunological structures. The increased amount of MMP-2 and bFGF positive cells was detected in the CLP group in cartilage and bone (p < 0.05), compared to the controls. A statistically significant (p = 0.012) increased amount of BMP 2/4 positive cells was found in cartilage of CLP patients, in comparison to the control group. Increased appearance of MMP-2, bFGF in hard tissue of the CLP patients indicates the predominance of tissue degradation. Increased number of BMP2/4 positive chondrocytes suggests improved cartilage growth and better regeneration in CLP patients.

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Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Appearance and Distribution of Tissue Remodellation Factors in the Hard Tissue of Patients Affected by Cleft Lip Palate

Buile

Pilmane

Akota

2020

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…There are a number of successful Ca-P ceramic scaffolds or fillers already available on the market used in cancellous bone replacement in non load-bearing indications (JectOS/ARE-X®BONE, CustomBone®, CronOS®, Engipore®). Unfortunately clinical solutions for cortical bone regeneration remain extremely limited [9,[18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Bone-like ceramic scaffolds designed with bioinspired porosity induce a different stem cell response

Panseri

Montesi

Hautcoeur

et al. 2021

J Mater Sci: Mater Med

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Biomaterial science increasingly seeks more biomimetic scaffolds that functionally augment the native bone tissue. In this paper, a new concept of a structural scaffold design is presented where the physiological multi-scale architecture is fully incorporated in a single-scaffold solution. Hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) bioceramic scaffolds with different bioinspired porosity, mimicking the spongy and cortical bone tissue, were studied. In vitro experiments, looking at the mesenchymal stem cells behaviour, were conducted in a perfusion bioreactor that mimics the physiological conditions in terms of interstitial fluid flow and associated induced shear stress. All the biomaterials enhanced cell adhesion and cell viability. Cortical bone scaffolds, with an aligned architecture, induced an overexpression of several late stage genes involved in the process of osteogenic differentiation compared to the spongy bone scaffolds. This study reveals the exciting prospect of bioinspired porous designed ceramic scaffolds that combines both cortical and cancellous bone in a single ceramic bone graft. It is prospected that dual core shell scaffold could significantly modulate osteogenic processes, once implanted in patients, rapidly forming mature bone tissue at the tissue interface, followed by subsequent bone maturation in the inner spongy structure.

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Comparative in vivo study of alloy titanium implants with two different surfaces: biomechanical and SEM analysis

et al. 2019

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Maxillary Sinus Elevation Surgery with ChronOS and Autogenous Bone Graft: Immunohistochemical Assessment of RUNX2, VEGF, TRAP, and Osteocalcin

Cited by 6 publications

References 0 publications

Appearance and Distribution of Tissue Remodellation Factors in the Hard Tissue of Patients Affected by Cleft Lip Palate

Appearance and Distribution of Tissue Remodellation Factors in the Hard Tissue of Patients Affected by Cleft Lip Palate

Bone-like ceramic scaffolds designed with bioinspired porosity induce a different stem cell response

Comparative in vivo study of alloy titanium implants with two different surfaces: biomechanical and SEM analysis

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