MATTER EXCHANGE BETWEEN BLOOD AND CEREBROSPINAL FLUID IN PSYCHOSIS; STUDIES WITH RADIOISOTOPES Na²⁴, I¹³¹AND P³²

Abstract

Summary Matter exchange between the blood and cerebrospinal fluid in psychosss was set under investigation, using radioisotopes Na24, P32 and I131 as the material. The clinical cases consist of 111 cases of schizophrenia, 47 cases of syphilitic psychoses, 30 cases of senile psychosis, 38 cases of epilepsy, 20 cases of psychoneuroses, sum total making up 246 cases. The result was as follows: 1) Na24, I131 and P32were proved pcsitive in the CSF 5 min. after intravenous injection, giving the transfer curve characteristic to each substance. The velocity of transfer was Na<P<I in order. In cass where they were proved in the blood after intralumbar injection, there occurred the same, with velocity of transfer in order of I<P>Na, the status of transfer in both situations developing quite different in quantity and velocity. 2) The transfer curve of Schizophrenic groups was different to other organic psychoses, relatively near to that of psychoneuroses. 3) The state of thansfer in syphilitic psychoses group fell slow in proceeding and small in quantity, especially concerning transfer of 1131 and P32 from CSF to the blood. 4) The state of transfer in senile psychoses group showed a tendency to get delayed always, but less so than in syphilitic group, and transfer of Na24 in the two situations, i. e. from CSF to blood and from blood to CSF, had a reverse tendency in the aspect of quantity. 5) Epileptic group was generally alike to schizophrenic group as regards the transfer state. But the transfer state of Na24 was different in quantity from the latter. 6) The transfer curve of psychrneouroses group was relatively alike to schizophrenic group. But transfer state of Na24 and I131 was different both in quantity and velocity from the said group. 7) The present experimental result must throw a light to the mechanism of matter exchange between the blood and CSF at the least.