Matrix tablets based on a carrageenan with the modified-release of sodium riboflavin 5′-phosphate

Abstract

The focus of this work was to produce modified-release monolithic matrix tablets containing sodium riboflavin 5'-phosphate (vitamin B2) as active pharmaceutical ingredient (API). Riboflavin 5'-phosphate is absorbed from the upper gastrointestinal tract by a specific transport mechanism. The aim of this work was the development of modified-release tablets from which most or the entire API can dissolve within 5 h. The dissolution was started in medium pH 1.2 (gastric juice) and finished in medium pH 4.5. The matrix former was iota-carrageenan combined with microcrystalline cellulose (MCC) and lactose in different ratios. Factorial design was used in this work so as to study the effects of the MCC/lactose ratio on the parameters of the tablets, and especially on the dissolution process. The dissolution data were subjected to statistical analysis, and the release profiles were fitted with different models. It was found that the MCC/lactose ratio influenced the quality of the tablets to a high degree. The Korsmeyer-Peppas model proved to characterize the total dissolution profile best, but fitting of the separate sections was also possible with a linear model.

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

“…In another approach, carrageenan was associated with two drug models, diltiazem HCl and metoprolol tartrate, and the two studied complexes released the drug with different mechanism indicating two different drug/polymer interaction strengths (stronger interaction with diltiazem) [ 259 ]. Other recent developments included the use of carrageenan, combined with other matrix materials, to associate and release vitamin B2 [ 260 ] and lisinopril [ 261 ].…”

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

“…The release profile showed a uniform increase of up to 80%. Lactose influenced the behavior of the matrix; when there is less lactose, the elasticity of the matrix is greater, resulting in tablets with weak mechanical properties [ 134 ].…”

Microspheres Based on Blends of Chitosan Derivatives with Carrageenan as Vitamin Carriers in Cosmeceuticals

“…Kasapis et al (2015) developed a carrier of ĸ-carrageenan/glucose syrup to control the release of thiamin (Vitamin B1) [30]. Buchholz et al (2015) reported modified-release matrix tablets based on carrageenan combined with microcrystalline cellulose and lactose, containing vitamin B2 [31]. Human skin is exposed to oxidative damage caused by free radicals, which is one of the main causes of skin aging.…”