Matrix-producing Breast Carcinoma: A Rare Subtype of Metaplastic Breast Carcinoma

Koufopoulos, Nektarios; Kokkali, Stefania; Antoniadou, Foteini; Dimas, Dionysios; Missitzis, Ioannis

doi:10.7759/cureus.5188

Cited by 9 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite its rarity, it shows an increased frequency in MGACAs. It is characterized by invasive carcinoma transitioning directly to a cartilaginous and/or osseous stromal matrix lacking an intervening spindle cell component [ 22 ]. Its differential diagnosis includes invasive breast carcinoma with a large central acellular zone, spindle cell carcinoma, primary or secondary chondrosarcoma, malignant phyllodes tumor with heterologous (chondrosarcomatous) differentiation, carcinoma ex-pleomorphic adenoma of the breast, and invasive lobular carcinoma with extracellular mucin production [ 6 , 23 , 24 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Its differential diagnosis includes invasive breast carcinoma with a large central acellular zone, spindle cell carcinoma, primary or secondary chondrosarcoma, malignant phyllodes tumor with heterologous (chondrosarcomatous) differentiation, carcinoma ex-pleomorphic adenoma of the breast, and invasive lobular carcinoma with extracellular mucin production [ 6 , 23 , 24 , 25 , 26 ]. An inspection of the histological detail paired with the appropriate immunohistochemical stains will usually resolve diagnostic dilemmas [ 22 ]. The most frequent gene mutation in all the histological subtypes of metaplastic carcinomas is TP53, followed in frequency by PIK3CA, TERT, KTM2D, PIK3R1, PTEN, RB1, NF1, HRAS, and ARID1A [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metaplastic Matrix-Producing Carcinoma and Apocrine Lobular Carcinoma In Situ Associated with Microglandular Adenosis: A Unique Case Report

et al. 2022

Self Cite

View full text Add to dashboard Cite

Microglandular adenosis is a non-lobulocentric haphazard proliferation of small round glands composed of a single layer of flat to cuboidal epithelial cells. The glandular structures lack a myoepithelial layer; however, they are surrounded by a basement membrane. Its clinical course is benign, when it is not associated with invasive carcinoma. In around 30% of cases, there is a gradual transition to atypical microglandular adenosis, carcinoma in situ, and invasive breast carcinoma of several different histologic subtypes, including an invasive carcinoma of no special type, metaplastic matrix-producing carcinoma, secretory carcinoma, metaplastic carcinoma with squamous differentiation, acinic cell carcinoma, spindle cell carcinoma, and adenoid cystic carcinoma. Recent molecular studies suggest that microglandular adenosis is a non-obligate precursor of triple-negative breast carcinomas. In this manuscript, we present a unique case of microglandular adenosis associated with metaplastic matrix-producing carcinoma and HER-2 neu oncoprotein positive pleomorphic lobular carcinoma in situ with apocrine differentiation in a 79-year-old patient.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metaplastic Matrix-Producing Carcinoma and Apocrine Lobular Carcinoma In Situ Associated with Microglandular Adenosis: A Unique Case Report

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…MPC is an invasive breast carcinoma with a direct transition of carcinoma to the cartilaginous or osseous matrix without an intervening spindle cell component ( 1 ). The cartilaginous or osseous matrix components at the tumor center and epithelial carcinoma components at the tumor margin manifest on contrast CT and MRI as ring enhancement, which are important diagnostic findings of MPC ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

A case of matrix-producing carcinoma of the breast treated with preoperative chemotherapy

Kimura¹,

Yamada²,

Shibata³

et al. 2022

Gland Surg

View full text Add to dashboard Cite

Background: Matrix-producing carcinoma (MPC) is a rare tumor accounting for 0.1% of all breast cancers. Although MPC is usually triple-negative breast cancer, there have been few reports of preoperative chemotherapy for MPC that is considered chemotherapy-resistant. Herein, we report a case of MPC that was successfully treated with preoperative chemotherapy.Case Description: The patient was a 47-year-old woman diagnosed with right multiple breast cancer, clinical stage IIA. One of the tumors was identified as MPC and the other was invasive ductal carcinoma.The maximum tumor diameter of MPC was 3.8-cm. On immunohistochemistry, the tumor cells of MPC tested negative for estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2). The Ki67 index was 90%. Preoperative chemotherapy was performed. EC (epirubicin 90 mg/m 2 and cyclophosphamide 600 mg/m 2 ) was administered every 3 weeks for a total of 4 courses, followed by 12 courses of weekly paclitaxel (80 mg/m 2 ). Then, she underwent right skin-sparing mastectomy, sentinel lymph node biopsy, and deep inferior epigastric perforator flap reconstruction. There was no metastasis to the sentinel lymph nodes. Postoperative pathological results showed that the residual tumor of the MPC measured only 0.1 cm. On the other hand, the residual tumor of the invasive ductal carcinoma was 0.7 cm. Endocrine therapy with oral tamoxifen was initiated for the invasive ductal carcinoma. Three years after surgery, no recurrence was observed. It has been reported that prognosis was correlated with residual cancer after preoperative chemotherapy. In addition, preoperative chemotherapy is of high clinical significance for the selection of postoperative treatment. In conclusion, Conclusions: Although our case of MPC was successfully treated with preoperative chemotherapy, the standard of care for MPC remains uncertain. Development of a new targeted therapy for MPC is warranted.

show abstract

“…This may be explained by the fact that the initial diagnosis was made in limited biopsy specimens in which only the mucinous area was sampled [11]. The differential diagnosis includes pure mucinous carcinoma, mixed mucinous- no special type carcinoma, solid papillary carcinoma, polymorphous mammary carcinoma [9], and metaplastic matrix-producing carcinoma [12]. Pure mucinous carcinoma lacks the component with the morphological characteristics of ILC.…”

Section: Discussionmentioning

confidence: 99%

“…The mucoid-like stroma of polymorphous mammary adenocarcinoma and matrix-producing carcinoma may be confused with the mucin lakes of ILC with extracellular mucin production. Lack of expression of estrogen and progesterone receptors in both tumors as well as other characteristics will help distinguish them from ILC [12,13]. In all the previously mentioned entities, when facing diagnostic difficulty, an immunohistochemical panel consisting of E-cadherin, b-catenin, and P120 immunostains will give the solution.…”

Section: Discussionmentioning

confidence: 99%

Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature

Koufopoulos¹,

Antoniadou²,

Kokkali³

et al. 2019

Cureus

Self Cite

View full text Add to dashboard Cite

Invasive lobular carcinoma of the breast is the second most common subtype of breast carcinoma. It accounts for 5-15% of the breast carcinoma cases reported. It shows a different metastatic pattern compared to invasive carcinoma of no special type. There are several variants of this cancer including the classic, solid, signet ring cell, tubulolobular, alveolar, trabecular, pleomorphic, and mixed subtypes each one with a distinctive morphology. Invasive lobular carcinoma has been associated with intracellular mucin production, in the form of intracytoplasmic lumina and signet ring cells whereas extracellular mucin production has been related to carcinomas of ductal origin. A new variant that displays extracellular mucin production was described recently. Only nineteen cases of this rare entity have been reported to date. In this manuscript, we report an additional case of invasive lobular carcinoma with extracellular mucin production, describing its clinico-pathological characteristics, and review the literature on the same.

show abstract

Matrix-producing Breast Carcinoma: A Rare Subtype of Metaplastic Breast Carcinoma

Cited by 9 publications

References 15 publications

Metaplastic Matrix-Producing Carcinoma and Apocrine Lobular Carcinoma In Situ Associated with Microglandular Adenosis: A Unique Case Report

Metaplastic Matrix-Producing Carcinoma and Apocrine Lobular Carcinoma In Situ Associated with Microglandular Adenosis: A Unique Case Report

A case of matrix-producing carcinoma of the breast treated with preoperative chemotherapy

Invasive Lobular Carcinoma with Extracellular Mucin Production: Description of a Case and Review of the Literature

Contact Info

Product

Resources

About