Metaplastic Matrix-Producing Carcinoma and Apocrine Lobular Carcinoma In Situ Associated with Microglandular Adenosis: A Unique Case Report

Koufopoulos, Nektarios; Dimas, Dionysios; Antoniadou, Foteini; Sitara, Kyparissia; Balalis, Dimitrios; Boutas, Ioannis; Gouloumis, Alina Roxana; Kontogeorgi, Adamantia; Khaldi, Lubna

doi:10.3390/diagnostics12061458

Cited by 6 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides a malignant phyllodes tumor, some breast tumors with components of spindle cells with myxoid matrix or spindle cells with giant cells have to be listed for the differential diagnosis. These include myxofibroblastoma, and metaplastic carcinoma [22][23][24]. Especially, the exclusion of metaplastic carcinoma is very important because of the difference in the treatment strategy in advanced cases [25].…”

Section: Discussionmentioning

confidence: 99%

Myxofibrosarcoma of the Breast: A Case Report

Amaya¹,

Okimura²,

Honda³

et al. 2023

Cureus

View full text Add to dashboard Cite

Development of a myxofibrosarcoma in the breast tissue is extremely rare. Reported here is a case of myxofibrosarcoma found in the left breast tissue of a male in his late fifties. The patient first underwent tumor resection, followed by a left mastectomy with the reconstruction of the vastus lateralis valve. The tumor comprised atypical spindle-shaped cells in a myxoid matrix with elongated blood vessels. Myxofibrosarcoma was diagnosed based on histology and immunohistochemical examination results performed for differential diagnosis. At two years and two months after the mastectomy, no local occurrence or metastasis had occurred.

show abstract

Section: Discussionmentioning

confidence: 99%

Myxofibrosarcoma of the Breast: A Case Report

Amaya¹,

Okimura²,

Honda³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…In mixed ILC and invasive mucinous carcinoma, immunostaining for E-cadherin will delineate the two different immunophenotypes. MMPC [ 41 ] and polymorphous mammary adenocarcinoma [ 42 , 43 ] also resemble ILC with extracellular mucin production since the former has a mucoid/matrix stroma, and the latter may simulate the single-file pattern of ILC [ 42 , 44 ]. Immunohistochemically, they may lack E-cadherin expression [ 42 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemically, they may lack E-cadherin expression [ 42 , 45 ]. Moreover, both tumors lack ER expression, while MMPC also shows positive staining for S-100 with rare exceptions [ 41 , 46 ]. Finally, one should also not forget the possibility (albeit rare) of metastatic signet-ring cell carcinomas to the breast [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

et al. 2022

Self Cite

View full text Add to dashboard Cite

Invasive lobular carcinoma is the most common special breast carcinoma subtype, with unique morphological (discohesive cells, single-cell files, targetoid pattern) and immunohistochemical (loss of E-cadherin and β-catenin staining) features. Moreover, ILC displays a poor response to neoadjuvant therapy, a different metastatic pattern compared to invasive breast carcinoma of no special type, as well as unique molecular characteristics. In addition to the classic variant of invasive lobular carcinoma, several other well-recognized variants exist, including classic, alveolar, tubulolobular, solid, pleomorphic, signet-ring, and mixed. Furthermore, three novel variants of invasive lobular carcinoma, i.e., with extracellular mucin production, papillary features, and tubular elements, have been described during the last decade. We herewith focus on the unique morphological and immunohistochemical characteristics of these novel varieties of invasive lobular carcinoma, as well as differential diagnostic considerations and potential diagnostic pitfalls, especially when dealing with biopsy specimens.

show abstract

“…MSCC and fibromatosis-like metaplastic carcinoma may simulate the histological features of MFB. Also, in rare cases with cartilaginous or osseous components, MMPC may enter the differential diagnosis [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Mammary Myofibroblastoma: Report of a Case and Review of the Literature

Koufopoulos¹,

Gouloumis²,

Dimas³

et al. 2022

Cureus

Self Cite

View full text Add to dashboard Cite

Mammary myofibroblastoma is a benign mesenchymal tumor composed of fibroblasts, myofibroblasts, and a variable number of adipocytes. Mammary myofibroblastoma usually occurs in men of older age and is less common in postmenopausal women. It may also happen in extramammary sites along the milk line. In this instance, it is referred to as mammary-type myofibroblastoma. Rarely multifocal and bilateral tumors have been described. Clinically and radiologically, it can be misinterpreted as a malignant tumor due to its rarity. Size usually does not exceed 3 cm. The diagnosis requires clinicopathological correlation with morphological and immunohistochemical evaluation, especially in limited biopsy specimens. We herewith describe a rare case of mammary myofibroblastoma in a 37-year-old female patient. We also review the literature focusing on the potential differential diagnostic issues and discuss this tumor's ultrastructural and cytogenetic findings.

show abstract

Metaplastic Matrix-Producing Carcinoma and Apocrine Lobular Carcinoma In Situ Associated with Microglandular Adenosis: A Unique Case Report

Cited by 6 publications

References 36 publications

Myxofibrosarcoma of the Breast: A Case Report

Myxofibrosarcoma of the Breast: A Case Report

Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

Mammary Myofibroblastoma: Report of a Case and Review of the Literature

Contact Info

Product

Resources

About