Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects

Elgezawi, Moataz; Haridy, Rasha; Almas, Khalid; Abdalla, Moamen A; Omar, Omar; Abuohashish, Hatem M.; ElEmbaby, Abeer; Wölfle, Uta Christine; Yasir, Siddiqui Muhammad; Kaisarly, Dalia

doi:10.3390/ijms23168929

Cited by 22 publications

(19 citation statements)

References 113 publications

(171 reference statements)

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“…This is the core element of N1 ( Figure 3 A), directly interconnected by miR-21 and miR-1. MiR-21 is upregulated in patients with periodontitis and in mice induced with a periodontitis field [ 14 , 17 ], confirmed by the present microarray data. The literature data present that the FOXO1 signaling axis can regulate periodontal bacteria–epithelial interactions, immune-inflammatory response, bone remodeling, and wound healing [ 25 ].…”

Section: Discussionsupporting

confidence: 80%

“…From a clinical point of view, these alterations are translated into inflammatory lesions of the connective tissue around teeth or implants, with progressive bone loss and increased probing depths with an accelerating pattern [ 15 ]. The ongoing homeostasis between the bone resorption matrix and the new bone formation matrix is altered [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Identification of a miRNA Panel with a Potential Determinant Role in Patients Suffering from Periodontitis

Baru

Ráduly

Bica

et al. 2023

CIMB

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In recent years, the role of microRNA (miRNA) in post-transcriptional gene regulation has advanced and supports strong evidence related to their important role in the regulation of a wide range of fundamental biological processes. Our study focuses on identifying specific alterations of miRNA patterns in periodontitis compared with healthy subjects. In the present study, we mapped the major miRNAs altered in patients with periodontitis (n = 3) compared with healthy subjects (n = 5), using microarray technology followed by a validation step by qRT-PCR and Ingenuity Pathways Analysis. Compared to healthy subjects, 159 differentially expressed miRNAs were identified among periodontitis patients, of which 89 were downregulated, and 70 were upregulated, considering a fold change of ±1.5 as the cut-off value and p ≤ 0.05. Key angiogenic miRNAs (miR-191-3p, miR-221-3p, miR-224-5p, miR-1228-3p) were further validated on a separate cohort of patients with periodontitis versus healthy controls by qRT-PCR, confirming the microarray data. Our findings indicate a periodontitis-specific miRNA expression pattern representing an essential issue for testing new potential diagnostic or prognostic biomarkers for periodontal disease. The identified miRNA profile in periodontal gingival tissue was linked to angiogenesis, with an important molecular mechanism that orchestrates cell fate.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Identification of a miRNA Panel with a Potential Determinant Role in Patients Suffering from Periodontitis

Baru

Ráduly

Bica

et al. 2023

CIMB

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“…MMP-1 and MMP-8 are representative enzymes known to destroy periodontal tissues, both of which are responsible for the breakdown of collagen types I, II, and III [18][19][20]. As a collagenase, MMP-13 is considered to play an important role in periodontal matrix degradation [21]. MMP-9 belongs to gelatinases, which are mainly secreted by progressive multifocal leukoencephalopathy that can degrade collagen type IV present in gingival tissues [22,23].…”

Section: Introductionmentioning

confidence: 99%

Magnolia kobus Extract Inhibits Periodontitis-Inducing Mediators in Porphyromonas gingivalis Lipopolysaccharide-Activated RAW 264.7 Cells

Lee¹,

Lee²,

Lee³

et al. 2023

CIMB

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Periodontitis, a disease caused by inflammation of oral bacteria, contributes to the loss of alveolar bone and destruction of connective tissues. Porphyromonas gingivalis, a Gram-negative bacterium, is known to possess important pathogenic factors for periodontal disease. In this study, we investigated the anti-periodontitis effects of Magnolia kobus extract (MKE) and magnolin as a component of Magnolia kobus (MK) in murine macrophage RAW 264.7 cells stimulated with Porphyromonas gingivalis lipopolysaccharide (LPS). Effects of MKE and magnolin on the mechanism of RAW 264.7 cellular inflammation were determined by analyzing nitric oxide (NO) production and Western blot protein expression (n = 3). MKE/magnolin inhibited NO production without affecting cell survival. MKE/magnolin treatment inhibited LPS-induced pro-inflammatory cytokines, expression levels of matrix metalloproteinases (MMPs such as MMP-1, 3, 8, 9, and 13), and protein levels of inflammatory mediators (such as TNF-α, IL-1β, and mPGES-1). MKE/magnolin also suppressed NF-κB activation by inhibiting the TLR4 signaling pathway. These findings suggest that MKE has a therapeutic effect on inflammatory periodontal disease caused by oral bacterium P. gingivalis and that magnolin is a major functional component in the anti-inflammatory effect of MKE.

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“…In the current study, MDP containing universal adhesive has been used since MDP containing bonding agents have been reported for long term bond stability and anti-Matrix metalloproteinases effects thus resisting hybrid layer degradation over time (35) .…”

Section: Discussionmentioning

confidence: 99%

Biological evaluation of Partial caries removal in class II resin composite restorations with two different clinical endpoints of excavation: A 12-month clinical study

Haridy

2023

Egyptian Dental Journal

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Background: Partial caries removal has received an increasing interest of dental clinicians and researchers with growing evidence of potential clinical effectiveness and long-term reliability.Objective: This is a prospective clinical study into the biological reliability of partial caries excavation in class II resin composite restorations. Materials and Methods: 40 patients with one deep class II lesion each have been recruitedfor the study (n=20). Class II cavities were prepared to produce sound enamel walls and hard dentin walls at cavity peripheries. Recruited subjects were classified into two groups according to the clinical end point of caries excavation. In group S, a layer of soft caries is left behind at the deepest part of the cavity while in group L, caries was excavated till leathery/firm dentin. A universal adhesive system was used employing the selective enamel etching strategy. A nanohybrid resin composite Neo Spectra ST was used to fill the cavities. Restored teeth were assessed at three week, three months, 6 months, and 12 months respectively for pulp vitality and post operative hypersensitivity. Chi-Square test was used for statistical analysis at a level of significance (P£ 0.05) Results: None of the restored teeth showed signs of irreversible pulpitis or apical periodontitis at any study interval. There was insignificant difference between the test groups at three weeks, three months, six months, and 12 months respectively (P> 0.05). Conclusion:Partial caries removal appears to be a clinically effective procedure that preserves pulp vitality in deep class II resin composite restorations.

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Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects

Cited by 22 publications

References 113 publications

Identification of a miRNA Panel with a Potential Determinant Role in Patients Suffering from Periodontitis

Identification of a miRNA Panel with a Potential Determinant Role in Patients Suffering from Periodontitis

Magnolia kobus Extract Inhibits Periodontitis-Inducing Mediators in Porphyromonas gingivalis Lipopolysaccharide-Activated RAW 264.7 Cells

Biological evaluation of Partial caries removal in class II resin composite restorations with two different clinical endpoints of excavation: A 12-month clinical study

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