“…Highly increased FAK expression and cell migration were found in various malignant tumors including breast cancer, kidney cancer, osteosarcoma and chondrosarcoma (Golubovskaya et al, 2002;Golubovskaya et al, 2009;Jenq et al, 1996;Lee et al, 2003;Schroder et al, 2002;Tan et al, 2009). For invasion of cancer cells, the production of the ECM components such as type II collagen and GAGs, and expression of integrins, FAK and matrix metalloproteinases (MMPs) is necessary (Golubovskaya et al, 2009;Joo and Seomun, 2008;Lee et al, 2003). Cell proliferation and type II collagen expression were increased by type II collagen stimulation and reduced by FAK knockdown in normal human articular chondrocytes while GAG secretion remained unchanged (Kim and Lee, 2009).…”