Matrix metalloproteinase family gene polymorphisms and risk for coronary artery disease: systematic review and meta-analysis

Niu, Wenquan; Qi, Yue

doi:10.1136/heartjnl-2012-302085

Cited by 38 publications

(31 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…SNP rs679620 of MMP3 gene showed extremely strong association with MMP3 protein levels in CSF (p=6.36E-26) and showed mean heterogeneity but no variance heterogeneity. SNP rs679620 is a nonsynonymous variant in the matrix metallopeptidase 3 (MMP3) gene that results in a change from Lysine to Glutamic acid at amino acid position 45 in the MMP3 protein and has been implicated in several human disease processes [Niu and Qi 2012]. The association analysis of SNPs surrounding rs679620 with MMP3 protein levels in CSF (Figure 1) illustrated that SNPs in LD with the functional SNP showed both mean and variance heterogeneity.…”

Section: Resultsmentioning

confidence: 99%

A Versatile Omnibus Test for Detecting Mean and Variance Heterogeneity

Cao

Wei

Bailey

et al. 2013

Genetic Epidemiology

140

View full text Add to dashboard Cite

Recent research has revealed loci that display variance heterogeneity through various means such as biological disruption, linkage disequilibrium (LD), gene-by-gene (GxG), or gene-by-environment (GxE) interaction. We propose a versatile likelihood ratio test that allows joint testing for mean and variance heterogeneity (LRTMV) or either effect alone (LRTM or LRTV) in the presence of covariates. Using extensive simulations for our method and others we found that all parametric tests were sensitive to non-normality regardless of any trait transformations. Coupling our test with the parametric bootstrap solves this issue. Using simulations and empirical data from a known mean-only functional variant we demonstrate how linkage disequilibrium (LD) can produce variance-heterogeneity loci (vQTL) in a predictable fashion based on differential allele frequencies, high D’ and relatively low r2 values. We propose that a joint test for mean and variance heterogeneity is more powerful than a variance only test for detecting vQTL. This takes advantage of loci that also have mean effects without sacrificing much power to detect variance only effects. We discuss using vQTL as an approach to detect gene-by-gene interactions and also how vQTL are related to relationship loci (rQTL) and how both can create prior hypothesis for each other and reveal the relationships between traits and possibly between components of a composite trait.

show abstract

Section: Resultsmentioning

confidence: 99%

A Versatile Omnibus Test for Detecting Mean and Variance Heterogeneity

Cao

Wei

Bailey

et al. 2013

Genetic Epidemiology

140

View full text Add to dashboard Cite

show abstract

“…MMPs have been implicated in BBB disruption in different neuroinflammatory diseases [34,36]. MMP-9 belong to gelatinase B group and digest the denatured collagens, gelatins Beside the digesting of extracellular matrix components, MMP-3 activates a number of proMMPs, such as proMMP-1 [37]. The results of these investigations prove that in the model of EAE in both WT and KO mice, activated microglia releases MMP-3 and MMP-9.…”

Section: Discussionmentioning

confidence: 92%

The Use of Agmatine Provides the New Insight in an Experimental Model of Multiple Sclerosis

et al. 2015

View full text Add to dashboard Cite

The aim of the study is to investigate the hypothesis that agmatine (AGM) enhances blood brain barrier (BBB) compounds properties in experimental autoimmune encephalomyelitis (EAE), which is an established animal model for studying multiple sclerosis (MS). Wild-type (WT) and knockout (KO) CBA/H iNOS-/- mice, 3 months old (15 ± 5 g) were used for EAE induction by myelin basic protein (MBP) dissolved in complete Freund's adjuvant (CFA). The animals were divided into control, CFA, EAE, EAE + AGM and AGM groups. After the development of full clinical remission, the animals were sacrificed and the immunohistochemical and biochemical examinations were performed in brain homogenates. We had noticed the increased expressions of occludin in WT and KO mice with EAE + AGM, compared to EAE groups in which these expressions were significantly decreased compared to the controls. The significant elevations of matrix metalloproteinases (MMPs)-MMP-3 and MMP-9 in WT and KO EAE animals were decreased during AGM treatment in both groups. AGM application post EAE in WT and KO mice caused decreased level of Iba-1 stain, compared to EAE groups. The obtained results suggest beneficial AGM effects in EAE on BBB components, which might be useful for novel therapeutic strategies in MS.

show abstract

“…Indeed, it is highly expressed in adipose tissue and atherosclerotic plaques, and it has been associated with obesity and atherosclerosis. 16,17 Experimental studies demonstrated that mouse MMP3 is involved in adipose tissue formation and that changes in its expression could be related to obesity-mediated adipose tissue remodeling. 12 Moreover, a study conducted in Pima Indians 18 showed that MMP3 gene was expressed in preadipocytes/stromal vascular cells and its expression was associated with variations in body fat.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of matrix metalloproteinase gene and adiposity indices in European children: results of the IDEFICS study

et al. 2013

View full text Add to dashboard Cite

on behalf of the IDEFICS Consortium OBJECTIVE: We investigated the relationship between matrix metalloproteinase 3 (MMP3) polymorphisms and adiposity indices in European children of the IDEFICS (Identification and Prevention of Dietary-and Lifestyle-Induced Health Effects in Children and Infants) project. SUBJECTS: A total of 16 224 Caucasian children (2-9 years) were recruited into a population-based survey from eight European countries. In all, 4540 children were randomly selected for genetic studies (T0); 3238 children were re-examined 2 years later (T1). Anthropometric measures were collected by standardized protocols at T0 and T1. RESULTS: Six variants of MMP3 gene were genotyped. Homozygotes for the variant A allele of rs646910 and for the H3 haplotype had higher hip circumference (P ¼ 0.002 and 0.001; age, sex and country adjusted) at T0. The association remained significant after false discovery rate (FDR) correction. At T1, subjects carrying rs646910 A/A genotype or H3/H3 diplotype showed significantly higher values of body mass index, waist and hip circumference and sum of tricipital and subscapular skinfolds, all associations remaining significant after FDR correction (P ¼ 0.020-0.048). CONCLUSIONS: We showed for the first time an association between the MMP3 rs646910 variant and indices of adiposity in European children, highlighting the involvement of metalloproteinase genes in adipose tissue remodeling and growth.

show abstract

Matrix metalloproteinase family gene polymorphisms and risk for coronary artery disease: systematic review and meta-analysis

Abstract: The results provided strong evidence regarding the susceptibility of MMP3 and MMP9 genes to the development of CAD. Future studies incorporating gene-gene and gene-environment interactions are encouraged.

Cited by 38 publications

References 67 publications

A Versatile Omnibus Test for Detecting Mean and Variance Heterogeneity

A Versatile Omnibus Test for Detecting Mean and Variance Heterogeneity

The Use of Agmatine Provides the New Insight in an Experimental Model of Multiple Sclerosis

Polymorphisms of matrix metalloproteinase gene and adiposity indices in European children: results of the IDEFICS study

Contact Info

Product

Resources

About