Matrix Metalloproteinase-Assisted Triggered Release of Liposomal Contents

Sarkar, Nihar; Banerjee, Jayati; Hanson, Andrea; Elegbede, Adekunle; Rosendahl, Theresa; Krueger, Aaron; Banerjee, Ashim; Tobwala, Shakila; Wang, Rongying; Lu, Xiaoning; Mallik, Sanku; Srivastava, D. K.

doi:10.1021/bc070081p

Cited by 66 publications

(67 citation statements)

References 34 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liposomes conjugated with targeted ligands can achieve active targeting of intended sites [51]. Several exogenous (e.g., temperature [53], light [54]) and endogenous (e.g., pH [55], enzymes [56, 57], redox [58]) triggers have been used to make stimuli-responsive drug delivery vehicles. Such formulations offer local control over payload release resulting in reduced systemic toxicity.…”

Section: Background Of Contrast Agent Applicationsmentioning

confidence: 99%

“…Fluorescent molecules like calcein [77, 242, 243] and carboxyfluorescein [244, 245] are often used as surrogates for hydrophilic drugs for evaluating triggered release from liposomes. Hence, ultrasound triggered release from ELIPs has also been studied by detecting changes in fluorescence due to the release of calcein or carboxyfluorescein.…”

Section: Characterization Of Echogenic Liposomes (Elip)mentioning

confidence: 99%

See 1 more Smart Citation

Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery

et al. 2014

Self Cite

View full text Add to dashboard Cite

Micron- to nanometer-sized ultrasound agents, like encapsulated microbubbles and echogenic liposomes, are being developed for diagnostic imaging and ultrasound mediated drug/gene delivery. This review provides an overview of the current state of the art of the mathematical models of the acoustic behavior of ultrasound contrast microbubbles. We also present a review of the in vitro experimental characterization of the acoustic properties of microbubble based contrast agents undertaken in our laboratory. The hierarchical two-pronged approach of modeling contrast agents we developed is demonstrated for a lipid coated (Sonazoid™) and a polymer shelled (poly D-L-lactic acid) contrast microbubbles. The acoustic and drug release properties of the newly developed echogenic liposomes are discussed for their use as simultaneous imaging and drug/gene delivery agents. Although echogenicity is conclusively demonstrated in experiments, its physical mechanisms remain uncertain. Addressing questions raised here will accelerate further development and eventual clinical approval of these novel technologies.

show abstract

Section: Background Of Contrast Agent Applicationsmentioning

confidence: 99%

Section: Characterization Of Echogenic Liposomes (Elip)mentioning

confidence: 99%

Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…The triple helical structure makes the peptide a good substrate for collagenase MMPs while imparting resistance to cleavage by noncollagenase MMPs (MMP-7 and MMP-10) and other proteolytic enzymes. MMP can cleave between the amino acids glycine and isoleucine 89 . Liposomes containing 30% of such lipopeptide and 70% of 1-palmitoyl-2-oleoyl- sn -glycero-3-phosphocholine released their contents in the presence of MMP-9 in a concentration and time-dependent manner 88, 89 .…”

Section: Matrix Metalloproteinasesmentioning

confidence: 99%

Enzyme-Responsive Liposomes for the Delivery of Anticancer Drugs

2017

Self Cite

View full text Add to dashboard Cite

Liposomes are nanocarriers that deliver the payloads at the target site, leading to therapeutic drug concentrations at the diseased site and reduced toxic effects in healthy tissues. Several approaches have been used to enhance the ability of the nanocarrier to target the specific tissues, including ligand-targeted liposomes and stimuli-responsive liposomes. Ligand-targeted liposomes exhibit higher uptake by the target tissue due to the targeting ligand attached to the surface, while, the stimuli-responsive liposomes do not release their cargo unless they expose to an endogenous or exogenous stimulant at the target site. In this review, we mainly focus on the liposomes that are responsive to pathologically increased levels of enzymes at the target site. Enzyme-responsive liposomes release their cargo upon contact with the enzyme through several destabilization mechanisms: a) structural perturbation in the lipid bilayer, b) removal of a shielding polymer from the surface and increased cellular uptake, c) cleavage of a lipopeptide or lipopolymer incorporated in the bilayer, and d) activation of a prodrug in the liposomes.

show abstract

“…[70] and [23], © Wiley and American Chemical Society, respectively), and micelle or vesicle-like structures by microphase separation of amphiphilic compounds (C, reproduced with permission from Ref. [79] and [80], © American Chemical Society).…”

Section: Figmentioning

confidence: 99%

Collagen mimetic peptides: progress towards functional applications

2011

View full text Add to dashboard Cite

Traditionally, collagen mimetic peptides (CMPs) have been used for elucidating the structure of the collagen triple helix and the factors responsible for its stabilization. The wealth of fundamental knowledge on collagen structure and cell-extracellular matrix (ECM) interactions accumulated over the past decades has led to a recent burst of research exploring the potential of CMPs to recreate the higher order assembly and biological function of natural collagens for biomedical applications. Although a large portion of such research is still at an early stage, the collagen triple helix has become a promising structural motif for engineering self-assembled, hierarchical constructs similar to natural tissue scaffolds which are expected to exhibit unique or enhanced biological activities. This paper reviews recent progress in the field of collagen mimetic peptides that bears both direct and indirect implications to engineering collagen-like materials for potential biomedical use. Various CMPs and collagen-like proteins that mimic either structural or functional characteristics of natural collagens are discussed with particular emphasis on providing helpful information to bioengineers and biomaterials scientists interested in collagen engineering.

show abstract

Matrix Metalloproteinase-Assisted Triggered Release of Liposomal Contents

Cited by 66 publications

References 34 publications

Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery

Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery

Enzyme-Responsive Liposomes for the Delivery of Anticancer Drugs

Collagen mimetic peptides: progress towards functional applications

Contact Info

Product

Resources

About