Matrix metalloproteinase-9 gene polymorphism (-1562 C/T) and its correlation with diabetic nephropathy

Shalaby, Kholoud; Bahriz, Rania; Mahsoub, Nancy; El-Arman, Mohammed M.; El-Said, Ghada

doi:10.1186/s43162-021-00035-2

Cited by 7 publications

(4 citation statements)

References 30 publications

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“…However, our findings are in conflict with previous studies showing that DN affects both male and female sex equally 42 and remains stable among age groups 70 . Other studies have reported that patients with nephropathy have higher hypertension and HbA1c level, as well as dyslipidemia caused by renal injury 71,72 . This discrepancy with our results is explained by the use of antihypertensive and anti‐glycemic drugs by our patients and also by the comparable BMI between the DWN and DN groups 73 …”

Section: Discussioncontrasting

confidence: 99%

“…70 Other studies have reported that patients with nephropathy have higher hypertension and HbA1c level, as well as dyslipidemia caused by renal injury. 71,72 This discrepancy with our results is explained by the use of antihypertensive and anti-glycemic drugs by our patients and also by the comparable BMI between the DWN and DN groups. 73 The allelic and genetic association of the À790T/G variant with the risk of development of multiple diseases has been previously reported.…”

Section: Discussioncontrasting

confidence: 97%

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Association of matrix metalloproteinase‐2 gene variants with diabetic nephropathy risk

Sarray

Lamine

Dallel

et al. 2023

The Journal of Gene Medicine

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BackgroundDiabetic nephropathy is a highly destructive microvascular complication of diabetes. Genetic predisposition is involved in the pathogenesis of diabetic nephropathy, with multiple allelic polymorphisms associated with the development and progression of the disease, thereby increasing the overall risk. To date, no study is available that shows the association of matrix metalloproteinase‐2 (MMP‐2) gene polymorphisms with diabetic nephropathy risk. Thus, we investigated the potential genetic influence of MMP‐2 promoter variants in the development of diabetic nephropathy in type 2 diabetic patients.MethodsIn total, 726 type 2 diabetic patients and 310 healthy controls were included in the study and genotyped for MMP‐2, −1306C/T, −790T/G, −1575G/T and −735C/T by real‐time PCR. The analysis of the outcomes was performed assuming three genetic models. The threshold for statistical significance was set at 0.05.ResultsThe results showed that the minor allele frequency of the −790T/G variant was significantly higher in patients with and without nephropathy compared to controls. Furthermore, the distribution analysis revealed a significant association of the −790T/G variant, in all genetic models, with increased risk of diabetic nephropathy that persisted after adjusting for key covariates. No significant associations between MMP‐2, −1306C/T, −1575G/T, −735C/T and the risk of diabetic nephropathy were detected. Haplotype analysis identified two risk haplotypes GCGC and GTAC associated with diabetic nephropathy.ConclusionsThe present study is the first to demonstrate the allelic and genotypic association of the MMP‐2‐790T/G variant and two haplotypes with an increased risk of diabetic nephropathy in a Tunisian population with type 2 diabetes.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 97%

Association of matrix metalloproteinase‐2 gene variants with diabetic nephropathy risk

Sarray

Lamine

Dallel

et al. 2023

The Journal of Gene Medicine

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“…For example, the T allele has been related with a lower risk of developing diabetic nephropathy in Han Chinese (16). Similarly, Shalaby et al, argued that the T allele has a protective role for the development of (17). In a study investigating the relationship between diabetic foot ulcer and MMP9 profile in T2DM patients, it was observed that MMP9 expression level increased as the wound grade increased.…”

Section: Discussionmentioning

confidence: 99%

Mmp9 −1562 C/T Poli̇morfi̇zmi̇, Türk Ti̇p 2 Di̇abetes Melli̇tus Hastalarinda Artmiş Di̇yabeti̇k Reti̇nopati̇ Ri̇ski̇ İle İli̇şki̇li̇di̇r

İçduygu

Akgün

Alp

et al. 2023

SDÜ Tıp Fakültesi Dergisi

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Objective: Type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR) development is affected by genetic factors. Matrix metalloproteinases (MMPs) are involved in many cellular processes, such as remodeling of extracellular matrix proteins and angiogenesis. In this study, we investigated the relationship between MMP9 −1562 C/T (rs3918242) polymorphism and the development of T2DM and DR in Turkish population. Material and Methods: A total of 510 participants, involving 168 T2DM cases with DR, 168 T2DM cases without DR, and 174 controls, were included in the study. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was carried out to identify genotypes. Results: The CT, CT+TT genotypes and the T allele of the MMP9 −1562 C/T polymorphism were associated with increased risk of DR (p=0.001). On the other hand, no relationship was found between the development of T2DM and this polymorphism. In addition, CT (p=0.010) and CT+TT (p=0.015) genotype frequencies were found to be higher in proliferative diabetic retinopathy (PDR) cases compared to non-proliferative diabetic retinopathy (NPDR) cases, but after regression analysis, only insulin use (p=0.003) was found to be associated with the development of PDR. Conclusion: Our data show that the MMP9 −1562 C/T polymorphism is associated with the development of DR in Turkish T2DM patients, but no significant relationship was found between this polymorphism and the severity of DR and the development of T2DM.

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“…Genetic studies regarding the association of MMP gene polymorphism and DN provide conflicting results. Some show that certain polymorphisms of MMP-9 may be predictive factors in the development of diabetic nephropathy [30] and some suggest the protective role of the T allele SNP -1562C>T of MMP-9 against diabetic nephropathy [31,32]. It has also been shown that MMP-2 gene polymorphism is associated with susceptibility and disease progression of DN [33].…”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinase-2 (MMP-2 ) and-9 (MMP-9) gene variants and microvascular complications in type 2 diabetes patients

Andjelic

Radojković

Nikolić

et al. 2022

Balkan Journal of Medical Genetics

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Vascular complications are the leading cause of increased morbidity and mortality of diabetic patients. It has been postulated that matrix metalloproteinases MMP-2 and MMP-9, zinc-dependent endopeptidases through remodeling of the extracellular matrix, can contribute to the onset and progression of diabetic vascular complications. The aim of our study was to assess whether there is a major difference in single nucleotide polymorphisms in the MMP-2 (at position -1306C˃T) and MMP-9 (at position -1562C˃T) gene in type 2 diabetic patients and healthy controls and to determine whether there is an association of these gene variants with the presence of microvascular complications in diabetic patients. Our study included 102 type 2 diabetes patients and a control group which was comprised of 56 healthy controls. All diabetic patients were screened for microvascular diabetes complications. Genotypes were detected by polymerase chain reactions followed by restriction analyses with specific endonucleases and their frequencies were determined. The MMP-2 variant -1306C>T showed a negative correlation with type 2 diabetes (p=0.028). It was also shown that the presence of the -1306C allele increases the probability of developing type 2 diabetes. This was a 2.2 fold increase and that the -1306 T allele has a protective role in regards to type 2 diabetes. The MMP-2 variant -1306T showed a negative correlation with diabetic polyneuropathy (p=0.017), meaning that allele-1306T has a protective role in regards to diabetic polyneuropathy while the presence of allele -1306C increases the probability of developing diabetic polyneuropathy by 3.4 fold. Our study showed that the MMP-2 gene variant (-1306C) doubles the risk of developing type 2 diabetes, and for the first time an association of this gene variant and the presence of diabetic polyneuropathy was shown.

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Matrix metalloproteinase-9 gene polymorphism (-1562 C/T) and its correlation with diabetic nephropathy

Cited by 7 publications

References 30 publications

Association of matrix metalloproteinase‐2 gene variants with diabetic nephropathy risk

Association of matrix metalloproteinase‐2 gene variants with diabetic nephropathy risk

Mmp9 −1562 C/T Poli̇morfi̇zmi̇, Türk Ti̇p 2 Di̇abetes Melli̇tus Hastalarinda Artmiş Di̇yabeti̇k Reti̇nopati̇ Ri̇ski̇ İle İli̇şki̇li̇di̇r

Matrix metalloproteinase-2 (MMP-2 ) and-9 (MMP-9) gene variants and microvascular complications in type 2 diabetes patients

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