Matrix metalloproteinase-2-targeted superparamagnetic Fe₃O₄-PEG-G5-MMP2@Ce6 nanoprobes for dual-mode imaging and photodynamic therapy

Abstract

A novel matrix metalloproteinase 2-targeted superparamagnetic nanoprobes for MRI, NIR and photodynamic therapy of tumors have been developed. The nanoprobes can significantly inhibit the tumor growth compared with PBS and free Ce6.

Facile preparation of cancer cell membrane vehicle loaded with indocyanine green for effective photothermal therapy of cancer

“…The chemicals adopted in our research were from Sigma (MO, USA) unless otherwise stated. The human lung carcinoma cell line (A549) was purchased from ATCC (Virginia, USA) and cultured in Dulbecco's modified eagle medium (Gibco, California, USA) supplied with 10% foetal bovine serum (Gibco, California, USA) under standard conditions as previously reported [19]. Male Balb/c nude mice were purchased from the Model Animal Research Center of Nanjing University (Nanjing, China) and raised in standard specific pathogen free (SPF) condition with sufficient food supply.…”

Functionalization of Magnetic Nanoparticles with Organic Ligands toward Biomedical Applications

“…Moreover, in vivo results not only confirmed that it can act as a dual‐mode imaging probe for tumor diagnosis but also demonstrated that it could effectively suppress tumor growth (Figure 2b,c). [ 48 ] Charge‐switchable polymers are a kind of smart organic ligand that can switch its charge from negative or neutral to positive in response to a specific stimulus when it is used in different biological environments. [ 49 ] Thus, MNPs could be modified with charge‐convertible polymers to endow this nanohybrid with a unique charge‐convertible property for enhanced tumor targeting and cellular uptake.…”

“…The generated magnetitepoly(g-benzyl-L-glutamate) (PBLG) nanoparticles were further Reproduced with permission. [48] Copyright 2019, Royal Society of Chemistry.…”

“…b) In vivo fluorescence imaging and T 2 -weighted MRI of tumor sites after injection of Fe 3 O 4 -PEG-G5@Ce6 or Fe 3 O4-PEG-G5-MMP2@Ce6 nanoprobes into MGC-803 tumor-bearing mice. c) The relative tumor volume and body weight of mice after the treatments with Fe 3 O 4 -PEG-G5-MMP2@Ce6 nanoprobes, PEG-G5-MMP2@Ce6, PBS, and free Ce6 upon laser irradiation, as well as Hematoxylin and Eosin (H&E) staining images for major organs after 18 days of treatment with Fe 3 O 4 -PEG-G5-MMP2@Ce6 nanoprobes.Reproduced with permission [48]. Copyright 2019, Royal Society of Chemistry.…”

IR820 functionalized melanin nanoplates for dual-modal imaging and photothermal tumor eradication

“…[21][22][23][24][25][26] Likewise, NIR imaging with real-time behavior, noninvasiveness and high sensitivity has been developed for disease diagnosis. [27][28][29][30][31][32][33][34][35][36] However, its shortcomings, such as shallow tissue penetration depth, low spatial resolution and rapid, limit its clinical application. [37][38][39][40][41][42][43] Fortunately, PA imaging perfectly overcomes these problems.…”