Matrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the risk of ischemic stroke in a Tunisian population

Chehaibi, Khouloud; Hrira, Mohamed Yahia; Maatouk, Faouzi; Hamda, Khaldoun Ben; Slimane, Mohamed Naceur

doi:10.1016/j.jns.2014.04.036

Cited by 25 publications

(22 citation statements)

References 51 publications

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“…This functional polymorphism located at position-82 causes an A to G substitution that affects the AP-1 binding site in the MMP-12 gene, altering the expression of the gene [46]. This polymorphism had been studied in CAD [30], AAA [29] and ischemic patients [21] and it was suggested that, A allele was associated with smaller artery lumen in CAD patients with diabetes [46]. Despite of having diverse substrate specificity [43], data relation to this polymorphism are relatively inadequate.…”

Section: A/g Polymorphism Of Mmp-12 Genementioning

confidence: 99%

Association of MMP-1, 9, 12 and TIMP-1 gene polymorphisms in Malaysian male hypertensive subjects

Aalam¹,

Ramachandran²,

Heidari³

et al. 2018

biomedicalresearch

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Section: A/g Polymorphism Of Mmp-12 Genementioning

confidence: 99%

Association of MMP-1, 9, 12 and TIMP-1 gene polymorphisms in Malaysian male hypertensive subjects

Aalam¹,

Ramachandran²,

Heidari³

et al. 2018

biomedicalresearch

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“…The 2G-allele of this promoter has been noted to increase transcriptional activity by creating an E26 transcription factor binding site [60]. But Chehaibi et al evaluated the role of this 1G vs. 2G allele in IS incidence in Tunisian patients and did not find any association between the -1607 promoter gene polymorphism and IS incidence [61]. But this failed association might be due to the similarities in genotype frequency between patients with carotid artery atherosclerosis and controls ( p = 0.085).…”

Section: Matrix Metalloproteinase-1mentioning

confidence: 99%

“…This relationship, however, was not found to be replicated in a non-diabetic population. The A-allele of the MMP-12 rs2276109 polymorphism (A vs. G allele) has been shown to have a higher affinity for the transcription factor activator protein-1 [116], resulting in increased expression of MMP-12 [61]. …”

Section: Matrix Metalloproteinase-12mentioning

confidence: 99%

The Role of Matrix Metalloproteinase Polymorphisms in Ischemic Stroke

Chang

Stanfill

Pourmotabbed

2016

IJMS

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Stroke remains the fifth leading cause of mortality in the United States with an annual rate of over 128,000 deaths per year. Differences in incidence, pathogenesis, and clinical outcome have long been noted when comparing ischemic stroke among different ethnicities. The observation that racial disparities exist in clinical outcomes after stroke has resulted in genetic studies focusing on specific polymorphisms. Some studies have focused on matrix metalloproteinases (MMPs). MMPs are a ubiquitous group of proteins with extensive roles that include extracellular matrix remodeling and blood-brain barrier disruption. MMPs play an important role in ischemic stroke pathophysiology and clinical outcome. This review will evaluate the evidence for associations between polymorphisms in MMP-1, 2, 3, 9, and 12 with ischemic stroke incidence, pathophysiology, and clinical outcome. The role of polymorphisms in MMP genes may influence the presentation of ischemic stroke and be influenced by racial and ethnic background. However, contradictory evidence for the role of MMP polymorphisms does exist in the literature, and further studies will be necessary to consolidate our understanding of these multi-faceted proteins.

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“…Previous studies have suggested that MMPs may play a role in the development of several diseases, such as spontaneous early pregnancy failure (Nissi et al, 2013), solid and hematological malignancies (Chaudhary et al, 2013), and abdominal aortic aneurysms (Duellman et al, 2012). Several polymorphisms in the genes encoding MMP molecules have been studied in cardiovascular diseases (Chehaibi et al, 2014;Olsen et al, 2014;Opstad et al, 2014). It is essential to note that association study results may differ among populations owing to genetic variability between populations, including differences in allele frequencies and linkage disequilibrium structure (Neale and Sham, 2004).…”

Section: Introductionmentioning

confidence: 99%

rs3918242 MMP9 gene polymorphism is associated with myocardial infarction in Mexican patients

et al. 2016

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ABSTRACT. Several studies have demonstrated that matrix metalloproteinases (MMPs) play a major role in atherosclerotic plaque disruption and lead to myocardial infarction (MI). We investigated the association between the MMP1 -1607 1G/2G (rs1799750), MMP3 -1612 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms and the risk of developing MI in a Mexican mestizo cohort. The genotype analysis was performed using the restriction fragment length polymorphism-polymerase chain reaction technique in a group of 236 patients with a history of MI and 285 healthy controls. Similar distributions of rs1799750 and rs3025058 were observed in both groups; however, the MMP9 rs3918242 T allele and the CT genotype were associated with the risk of developing MI (OR = 2.32, pC = 0.02 and OR = 2.40, pC = 0.02, respectively). Multiple logistic analysis was performed between MI patients and controls to estimate the risk, and after adjusting for identified risk factors, the CT + TT genotypes of MMP9 rs3918242 were found to be significantly associated with increased risk of developing MI than those with the CC genotype (OR = 2.88, P < 0.01). In summary, our results reveal that the rs3918242 polymorphism of the MMP9 gene plays a major role in the risk of developing MI.

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Matrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the risk of ischemic stroke in a Tunisian population

Cited by 25 publications

References 51 publications

Association of MMP-1, 9, 12 and TIMP-1 gene polymorphisms in Malaysian male hypertensive subjects

Association of MMP-1, 9, 12 and TIMP-1 gene polymorphisms in Malaysian male hypertensive subjects

The Role of Matrix Metalloproteinase Polymorphisms in Ischemic Stroke

rs3918242 MMP9 gene polymorphism is associated with myocardial infarction in Mexican patients

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