Association of MMP-1, 9, 12 and TIMP-1 gene polymorphisms in Malaysian male hypertensive subjects

Aalam, Farizeh; Ramachandran, Vasudevan; Heidari, Farzad; Khazaei, Somayeh; Etemad, Ali; Ismail, Patimah

doi:10.4066/biomedicalresearch.29-17-470

Cited by 4 publications

(5 citation statements)

References 39 publications

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“…Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of MMPs and are consequently significant regulators of ECM turnover, as well as tissue remodeling. Dysregulation of the balance between MMPs and TIMPs is characteristic for some acute and chronic cardiovascular diseases [ 30 ]. Moreover, some authors have reported a relationship between MMP gene polymorphism and hypertensive disorders in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Effects of TIMP1 rs4898 Gene Polymorphism on Early-Onset Preeclampsia Development and Placenta Weight

et al. 2022

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Introduction: Some evidence indicates that the improper trophoblast invasion of maternal spiral arteries could be caused by an imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), leading to preeclampsia (PE) development. This study aimed to assess the potential role of MMP1, MMP9, TIMP1 and TIMP2 gene polymorphisms in the pathogenesis of PE. Materials and methods: A total of 308 Polish women, 115 preeclamptic (55 with early-onset preeclampsia [EOPE], 60 with late-onset preeclampsia [LOPE]) and 193 healthy pregnant women, all of Caucasian origin, were recruited to the study. PE was diagnosed following the ACOG criteria. The polymorphic variants of the MMP-TIMP pathway (MMP1 rs1799750, MMP9 rs17576, MMP9 rs17577, TIMP1 rs4898, TIMP2 rs2277698, TIMP2 rs55743137) were genotyped by polymerase chain reaction and restriction fragment length polymorphism. Results: Analyzing all SNPs in the MMP-TIMP pathway, no significant differences in allele frequencies between preeclamptic women and controls were observed. However, comparing the EOPE and LOPE groups with each other, we observed a statistically significant difference between them for the TIMP1 rs4898 variant. In the whole group of 308 women, the mean placenta weight was the lowest in carriers of the rs4898 CC genotype. Post hoc analysis revealed significant differences between CC-CT (p = 0.0209) and CC-TT (p = 0.0469). Additionally, during allele analysis, a statistically significant difference in the mean placenta weight (for C allele 529.32 ± 157.11 g, for T allele 560.24 ± 162.24 g, p = 0.021) was also observed. Conclusion: Our findings suggest a relationship between TIMP1 rs4898 (372T > C) polymorphism and increased risk of early-onset preeclampsia in a population of pregnant Polish women. Our data suggest that the TIMP1 rs4898 C allele might be associated with increased risk for early-onset, but not for late-onset preeclampsia. To evaluate the role of the TIMP1 polymorphic variants in the etiopathology of preeclampsia, further studies with a larger sample size are needed.

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Section: Discussionmentioning

confidence: 99%

Effects of TIMP1 rs4898 Gene Polymorphism on Early-Onset Preeclampsia Development and Placenta Weight

et al. 2022

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“…Studies on the MMP9 and TIMP1 gene polymorphisms in athletes are quite limited. Tabatabaee, Heidari [30] studied Malaysian males with hypertension and healthy individuals and investigated speci c gene polymorphisms including TIMP1 372 T/C. Allele frequencies of this polymorphism showed a signi cant difference between the two groups.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Maximal Exercise on Matrix Metalloproteinase, its Inhibitor (MMP9 and TIMP1), and the Role of MMP9 -1562 C/T and TIMP1 372 T/C Polymorphisms

Kosova

Turgay

Yigittürk

et al. 2021

Preprint

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To investigate the levels of MMP9 and TIMP1 before and after acute maximal exercise and the role of MMP9 -1562 C/T and TIMP1 372 T/C polymorphisms in athletes and sedentary individuals. The athlete group (n = 43) and sedentary group (n = 43) performed the Yo-Yo intermittent recovery test level 1. A blood sample was taken before and after the test. MMP9, TIMP1, MMP9/TIMP1 ratio, blood lipids, and lipoproteins (total cholesterol, high and low-density lipoprotein cholesterol) and indicators of muscle damage (creatine kinase, aspartate aminotransferase, alanine aminotransferase) were determined from postprandial venous blood samples. Genetic polymorphisms were determined from DNA samples obtained from peripheral blood. MMP9 levels were found higher in both groups after the YOYO IR-1 test (exercise) (sedentary group, pre-exercise: 1771.15 ± 862.17 pg/mL, post-exercise: 2172.18 ± 680.93 pg/mL; athletic group, pre-exercise: 1373.57 ± 705.16 pg/mL, post-exercise: 1723.72 ± 733.88 pg/mL, p < 0.05). TIMP1 levels were also found higher in both groups after exercise (sedentary group, pre-exercise: 4.63 ± 3.99 ng/mL, post-exercise: 5.3 ± 3.51 ng/mL; athletic group, pre-exercise: 3.26 ± 2.34 ng/mL, post-exercise: 3.59 ± 1.99 ng/mL, p < 0.05). Basal serum MMP9 levels were significantly higher in sedentary individuals as compared with athletes (p = 0.046). MMP9 -1562 C/T and TIMP1 372 T/C polymorphisms had no effect on MMP9 and TIMP1 levels (p > 0.05). As a conclusion acute exercise increases MMP9 and TIMP1 levels in male athletes and sedentary individuals. Chronic anaerobic exercises performed by the athletic group may caused lower MMP9 levels. MMP9 -1562 C/T and TIMP1 372 T/C genetic polymorphisms are not associated with MMP9 and TIMP1 activation.

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“…In the same study, MMP-1 (-1607 1G/2G) gene variation was not determined as an important biomarker for CVD such as ischemic stroke in diabetic patients [18]. In another study performed with the Malaysian population, MMP-1 (-1607 1G/2G) gene variation was not detected a genetic risk factor for the development of essential hypertension in male patients [8].…”

Section: Discussionmentioning

confidence: 99%

“…Various studies have been performed in different populations to investigate the relationship between genetic factors such as various genetic variations that may play a role in susceptibility to the development of ischemic stroke and the risk of developing ischemic stroke [8].…”

Section: Introductionmentioning

confidence: 99%

Determination of the role of Matrix Metalloproteinase-1 (-1607 1G/2G) gene variation in ischemic stroke development

Alkanlı¹

2021

Erciyes Med J

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Objective: Matrix Metalloproteinase (MMP) family is one of the potential genetic risk factors for the development of cerebrovascular disease such as ischemic stroke. Excessive MMP-1 protein production occurs and MMP-1 enzyme activity increases as a result of MMP-1 (-1607 1G/2G) gene variation. Thus, the sensitivity to ischemic stroke can be modulated. Therefore, the purpose of our study is to investigate the effect of MMP-1 (-1607 1G/2G) gene variation in development of ischemic stroke disease in the Thrace population of Turkey. Methods:Our study was performed with 87 ischemic stroke patients and 80 healthy controls.Polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) methods were used to determine genotype distributions of MMP-1 (-1607 1G/2G) gene variations.Results: In patient group, 1G/1G genotype (56.9%) and 1G/2G genotypes (55.1%) of MMP-1 (-1607 1G/2G) gene variation were observed higher compared to control group. However the significant difference was not determined between ischemic stroke patient and healthy control groups in terms of MMP-1 (-1607 1G/2G) gene variation genotype distributions (p=0.127, ns).Allele frequencies of MMP-1 (-1607 1G/2G) gene variation in ischemic stroke patient and healthy control groups were not found significantly different from the Hardy-Weinberg distribution (p= 0.6556, ns and p= 0.0501, ns respectively). Conclusion:1G/1G and 1G/2G genotypes of MMP-1 (-1607 1G/2G) gene variation were observed higher in ischemic stroke group compared to healthy control group. However, MMP-1 (-1607 1G/2G) gene variation was not determined as a genetic risk factor for development of ischemic stroke in Thrace population of Turkey.

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Association of MMP-1, 9, 12 and TIMP-1 gene polymorphisms in Malaysian male hypertensive subjects

Cited by 4 publications

References 39 publications

Effects of TIMP1 rs4898 Gene Polymorphism on Early-Onset Preeclampsia Development and Placenta Weight

Effects of TIMP1 rs4898 Gene Polymorphism on Early-Onset Preeclampsia Development and Placenta Weight

The Effect of Maximal Exercise on Matrix Metalloproteinase, its Inhibitor (MMP9 and TIMP1), and the Role of MMP9 -1562 C/T and TIMP1 372 T/C Polymorphisms

Determination of the role of Matrix Metalloproteinase-1 (-1607 1G/2G) gene variation in ischemic stroke development

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