Matrix-Based Bone Regenerative Engineering

Ogueri, Kenneth S.; Laurencin, Cato T.

doi:10.1016/b978-0-12-801238-3.62201-8

Cited by 2 publications

(4 citation statements)

References 93 publications

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“…In addition, the blend's compressive strength was comparable to that of the PLGA and within the range of the trabecular bone but fell short of that of the cortical bone. 1,30 Similar trends were also observed in the results for Young's, flexural, and compressive moduli.…”

Section: ■ Results and Discussionsupporting

confidence: 83%

“…The PNGEGPhPh–PLGA materials exhibited excellent tensile and flexural properties as these properties were superior to those of the pristine PLGA and similar to those of the native bone. In addition, the blend’s compressive strength was comparable to that of the PLGA and within the range of the trabecular bone but fell short of that of the cortical bone. , Similar trends were also observed in the results for Young’s, flexural, and compressive moduli.…”

Section: Resultssupporting

confidence: 75%

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In Vivo Evaluation of the Regenerative Capability of Glycylglycine Ethyl Ester-Substituted Polyphosphazene and Poly(lactic-co-glycolic acid) Blends: A Rabbit Critical-Sized Bone Defect Model

Ogueri

McClinton

et al. 2021

ACS Biomater. Sci. Eng.

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In an effort to understand the biological capability of polyphosphazene-based polymers, three-dimensional biomimetic bone scaffolds were fabricated using the blends of poly[(glycine ethylglycinato)75(phenylphenoxy)25]phosphazene (PNGEGPhPh) and poly(lactic-co-glycolic acid) (PLGA), and an in vivo evaluation was performed in a rabbit critical-sized bone defect model. The matrices constructed from PNGEGPhPh–PLGA blends were surgically implanted into 15 mm critical-sized radial defects of the rabbits as structural templates for bone tissue regeneration. PLGA, which is the most commonly used synthetic bone graft substitute, was used as a control in this study. Radiological and histological analyses demonstrated that PNGEGPhPh–PLGA blends exhibited favorable in vivo biocompatibility and osteoconductivity, as the newly designed matrices allowed new bone formation to occur without adverse immunoreactions. The X-ray images of the blends showed higher levels of radiodensity than that of the pristine PLGA, indicating higher rates of new bone formation and regeneration. Micro-computed tomography quantification revealed that new bone volume fractions were significantly higher for the PNGEGPhPh–PLGA blends than for the PLGA controls after 4 weeks. The new bone volume increased linearly with increasing time points, with the new tissues observed throughout the defect area for the blend and only at the implant site’s extremes for the PLGA control. Histologically, the polyphosphazene system appeared to show tissue responses and bone ingrowths superior to PLGA. By the end of the study, the defects with PNGEGPhPh–PLGA scaffolds exhibited evidence of effective bone tissue ingrowth and minimal inflammatory responses. Thus, polyphosphazene-containing biomaterials have excellent translational potential for use in bone regenerative engineering applications.

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Section: ■ Results and Discussionsupporting

confidence: 83%

Section: Resultssupporting

confidence: 75%

In Vivo Evaluation of the Regenerative Capability of Glycylglycine Ethyl Ester-Substituted Polyphosphazene and Poly(lactic-co-glycolic acid) Blends: A Rabbit Critical-Sized Bone Defect Model

Ogueri

McClinton

et al. 2021

ACS Biomater. Sci. Eng.

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confidence: 99%

“…The approach of regenerative engineering has witnessed tremendous growth and advancements in the past decade. − These advances (including sophisticated material design, development of induced pluripotent stem cells, fresh insights in cell biomechanics, etc. ) are stimulated by the desire to salvage limbs after major bone loss through technologies based on nanomaterials . In light of the urgent needs for a more effective treatment option for bone injury and deformities, regenerative engineering presents a multidisciplinary framework that interconnects and merges expertise from different fields such as advanced materials science, biophysics, stem cell science, developmental biology, and clinical translation for the active regeneration of complex tissues and organs. − This innovative and paradigm methodology is fascinating, and it circumvents most of the drawbacks associated with current treatment options .…”

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confidence: 99%

Nanofiber Technology for Regenerative Engineering

Ogueri

Laurencin

2020

ACS Nano

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Regenerative engineering is powerfully emerging as a successful strategy for the regeneration of complex tissues and biological organs using a convergent approach that integrates several fields of expertise. This innovative and disruptive approach has spurred the demands for more choice of biomaterials with distinctive biological recognition properties. An ideal biomaterial is one that closely mimics the hierarchical architecture and features of the extracellular matrices (ECM) of native tissues. Nanofabrication technology presents an excellent springboard for the development of nanofiber scaffolds that can have positive interactions in the immediate cellular environment and stimulate specific regenerative cascades at the molecular level to yield healthy tissues. This paper systematically reviews the electrospinning process technology and its utility in matrix-based regenerative engineering, focusing mainly on musculoskeletal tissues. It briefly outlines the electrospinning/three-dimensional printing system duality and concludes with a discussion on the technology outlook and future directions of nanofiber matrices.

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Matrix-Based Bone Regenerative Engineering

Cited by 2 publications

References 93 publications

In Vivo Evaluation of the Regenerative Capability of Glycylglycine Ethyl Ester-Substituted Polyphosphazene and Poly(lactic-co-glycolic acid) Blends: A Rabbit Critical-Sized Bone Defect Model

In Vivo Evaluation of the Regenerative Capability of Glycylglycine Ethyl Ester-Substituted Polyphosphazene and Poly(lactic-co-glycolic acid) Blends: A Rabbit Critical-Sized Bone Defect Model

Nanofiber Technology for Regenerative Engineering

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