Nanofiber Technology for Regenerative Engineering

Ogueri, Kenneth S.; Laurencin, Cato T.

doi:10.1021/acsnano.0c03981

Cited by 83 publications

(48 citation statements)

References 104 publications

(321 reference statements)

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“…In biomedical applications, scaffolds can be used ranging from regenerative engineering to managed drug delivery and immunomodulation; biomaterials have become an indispensable instrument [ 37 ]. Regenerative engineering is a multidisciplinary research area that uses the concepts of physics, stem cell science, advanced materials science, clinical translation, and developmental biology for damaged tissue regeneration [ 38 , 39 ].…”

Section: Polymers As Biomaterials For Scaffoldingmentioning

confidence: 99%

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

et al. 2021

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Tissue engineering (TE) and regenerative medicine integrate information and technology from various fields to restore/replace tissues and damaged organs for medical treatments. To achieve this, scaffolds act as delivery vectors or as cellular systems for drugs and cells; thereby, cellular material is able to colonize host cells sufficiently to meet up the requirements of regeneration and repair. This process is multi-stage and requires the development of various components to create the desired neo-tissue or organ. In several current TE strategies, biomaterials are essential components. While several polymers are established for their use as biomaterials, careful consideration of the cellular environment and interactions needed is required in selecting a polymer for a given application. Depending on this, scaffold materials can be of natural or synthetic origin, degradable or nondegradable. In this review, an overview of various natural and synthetic polymers and their possible composite scaffolds with their physicochemical properties including biocompatibility, biodegradability, morphology, mechanical strength, pore size, and porosity are discussed. The scaffolds fabrication techniques and a few commercially available biopolymers are also tabulated.

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Section: Polymers As Biomaterials For Scaffoldingmentioning

confidence: 99%

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

et al. 2021

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“…The same can be achieved by either surface functionalization or incorporation of bioactive materials in the nanofiber membrane. The nanofiber scaffold’s primary goal is to provide an appropriate microenvironment for bone tissue to restore and facilitate the bone tissue regeneration process [ 84 ]. Ideally, the fabrication of polyphenol-loaded electrospun nanofibers scaffolds has some advantages in bone tissue regeneration applications.…”

Section: Advantages Of Polyphenol-loaded Electrospun Nanofibersmentioning

confidence: 99%

Polyphenols-loaded electrospun nanofibers in bone tissue engineering and regeneration

et al. 2021

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Bone is a complex structure with unique cellular and molecular process in its formation. Bone tissue regeneration is a well-organized and routine process at the cellular and molecular level in humans through the activation of biochemical pathways and protein expression. Though many forms of biomaterials have been applied for bone tissue regeneration, electrospun nanofibrous scaffolds have attracted more attention among researchers with their physicochemical properties such as tensile strength, porosity, and biocompatibility. When drugs, antibiotics, or functional nanoparticles are taken as additives to the nanofiber, its efficacy towards the application gets increased. Polyphenol is a versatile green/phytochemical small molecule playing a vital role in several biomedical applications, including bone tissue regeneration. When polyphenols are incorporated as additives to the nanofibrous scaffold, their combined properties enhance cell attachment, proliferation, and differentiation in bone tissue defect. The present review describes bone biology encompassing the composition and function of bone tissue cells and exemplifies the series of biological processes associated with bone tissue regeneration. We have highlighted the molecular mechanism of bioactive polyphenols involved in bone tissue regeneration and specified the advantage of electrospun nanofiber as a wound healing scaffold. As the polyphenols contribute to wound healing with their antioxidant and antimicrobial properties, we have compiled a list of polyphenols studied, thus far, for bone tissue regeneration along with their in vitro and in vivo experimental biological results and salient observations. Finally, we have elaborated on the importance of polyphenol-loaded electrospun nanofiber in bone tissue regeneration and discussed the possible challenges and future directions in this field.

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“…Chen et al [ 10 ] summarized the methods for producing electrospun 1D nanofiber bundles, 2D nanofiber membranes, and 3D nanofiber scaffolds and indicate the possible combinations of electrospinning with 3D printing, flexible electrodes, and microfluidics for biomedical applications. Ogueri et al [ 11 ] reviewed electrospinning in matrix‐based regenerative engineering, focusing mainly on musculoskeletal tissues. Sun et al [ 12 ] discussed electrospinning techniques for fabricating 3D nanostructures, and He et al [ 13 ] summarized electrohydrodynamic‐based bioprinting techniques, including near‐field solution electrospinning, melt electrowriting, and electrospray cell printing.…”

Section: Introductionmentioning

confidence: 99%

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

Toftdal

Friec

et al. 2021

Small Science

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Tissue regeneration is a rapidly evolving and interdisciplinary field at the intersection of life science, biology, material science, and engineering. Centrally, it involves functional cell-free or cell-laden constructs or biomaterial scaffolds that are fabricated utilizing various strategies. [1] Cell-free biomaterial scaffolds implanted directly at the sites of injury may mechanically support local cells to promote local tissue repair. [2] Furthermore, they can be functionalized both on the surface or in the interior with bioactive materials to stimulate regeneration of functional tissues. [3] In cell therapy applications, cell-laden constructs may enhance both survival and differentiation of the therapeutic cells compared with cell transplantation alone. The grafted cells may then ideally replace lost tissue and/or exert beneficial effects on the host tissue. [4] Among different biomaterial constructs, 3D fibrous scaffolds recreate a 3D microenvironment, which closely resembles the native extracellular matrix (ECM), including both structural and biochemical properties that guide cell survival and differentiation. [5] Scaffolds with fibrous networks possess unique characteristics, including sufficiently high interconnected porosity, high specific surface area, tunable mechanical properties, as well as optimal morphological features. The high porosity of the fibrous scaffolds facilitates mass transfer for effective nutrient supply, oxygen diffusion, metabolic waste removal, and enhancement of intercellular communications, consequently allowing high cell viability and function throughout the entire scaffold. [6] In addition, compared with 2D culture, the 3D cell culture provides a more realistic biochemical and biomechanical microenvironment, [7] creating an optimal environment for cell migration, proliferation, and differentiation. Hence, nanofibrous scaffolds with appropriate biomechanical properties are highly suitable for tissue engineering. [8] Electrospinning, as a relatively simple and versatile fiber preparation technique, has been developed to create fiber-based constructs in combination with cells, bioactive molecules, proteins, and biocompatible nanomaterials. [9] Many studies have demonstrated that the electrospinning technology has the potential for significant progress within the field of tissue regeneration. Chen et al. [10] summarized the methods for producing electrospun 1D nanofiber bundles, 2D

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Nanofiber Technology for Regenerative Engineering

Cited by 83 publications

References 104 publications

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

Polyphenols-loaded electrospun nanofibers in bone tissue engineering and regeneration

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

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