Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF-κB signaling pathway

Shao, Hongmin; Yang, Baohui; Hu, Rongrong; Wang, Yingying

doi:10.3892/ol.2013.1399

Cited by 37 publications

(35 citation statements)

References 24 publications

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“…Breast cancer was the second leading cause of cancer related death among women worldwide. Although concerted efforts have been made in breast cancer therapy, it is still estimated that over 1,000,000 women are newly diagnosed with breast cancer every year worldwide and that more than 400,000 cases will die from breast cancer (Li et al, ; Shao et al, ; Li et al, ). Matrine was reported to effectively inhibit the proliferation of breast cancer cells, including endoplasmic reticulum (ER)‐positive Michigan Cancer Foundation (MCF) cells, HER2‐positive BT‐474 cells, and highly metastatic MDA‐MB‐231cells.…”

Section: Introductionmentioning

confidence: 99%

Matrine Suppresses the ER-positive MCF Cells by Regulating Energy Metabolism and Endoplasmic Reticulum Stress Signaling Pathway

Xiao

Wang

et al. 2017

Phytother. Res.

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Matrine (C H N O), an alkaloid that is one of the main active components from Sophora flavescens. Matrine has been demonstrated to have therapeutic effects on various solid tumors, including breast cancer, but the mechanism still needs further study. Endoplasmic reticulum (ER)-positive Michigan Cancer Foundation cells were cultured, and matrine was added in various amounts to measure the dose-dependent and time-dependent cytotoxicity. Hoechst 33258 staining was used to observed nuclear morphological changes. Apoptosis was measured by AnnexinV/PI double staining assay kit. Intracellular adenosine triphosphate and glycometabolism were detected by assay kit. The protein levels GRP78, p-eIF2α, CHOP, cytochrome c, and HexokinaseII were analyzed. Mechanistic investigations revealed that matrine treatment causes ER dilation and up-regulated the expression of ER stress markers GRP78, eIF2α, and CHOP, increases the levels of apoptotic in Michigan Cancer Foundation cells, subsequently, blocking the ER stress-mediated apoptosis pathway, significantly decreased matrine-induced apoptotic but still has significant difference between control group. In addition, matrine not only promoted the occurrence of ER stress but also inhibited the expression of hexokinase II, down-regulated energy metabolism. In summary, the present study suggests that the induction of ER stress-mediated apoptosis by matrine and down-regulated energy metabolism may account for its cytotoxic effects in human breast cancer cells. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Matrine Suppresses the ER-positive MCF Cells by Regulating Energy Metabolism and Endoplasmic Reticulum Stress Signaling Pathway

Xiao

Wang

et al. 2017

Phytother. Res.

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“…The death of cancer cells was observed in the matrine treatment group. The expression of the inhibitor of κB (IκB) kinase β (IKKβ) was downregulated by matrine in the NF-κB signaling pathway [12] . Another study indicated that matrine might suppress breast cancer cell (MCF-7) growth by inducing apoptosis and cell cycle arrest at the G 1 /S phase in a dose-and time-dependent manner via the miR-21/PTEN/Akt pathway.…”

Section: Introductionmentioning

confidence: 99%

Anti-tumor activities of active ingredients in Compound Kushen Injection

Wang¹,

et al. 2015

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Kushen (Radix Sophorae Flavescentis) has a long history of use for the treatment of tumors, inflammation and other diseases in traditional Chinese medicine. Compound Kushen Injection (CKI) is a mixture of natural compounds extracted from Kushen and Baituling (Rhizoma Smilacis Glabrae). The main principles of CKI are matrine (MT) and oxymatrine (OMT) that exhibit a variety of pharmacological activities, including anti-inflammatory, anti-allergic, anti-viral, anti-fibrotic and cardiovascular protective effects. Recent evidence shows that these compounds also produce anti-cancer actions, such as inhibiting cancer cell proliferation, inducing cell cycle arrest, accelerating apoptosis, restraining angiogenesis, inducing cell differentiation, inhibiting cancer metastasis and invasion, reversing multidrug resistance, and preventing or reducing chemotherapy-and/or radiotherapy-induced toxicity when combined with chemotherapeutic drugs. In this review, we summarize recent progress in studying the anti-cancer activities of MT, OMT and CKI and their potential molecular targets, which provide clues and references for further study.

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“…Matrine exerts several therapeutic effects on cancer cells, including antiangiogenic effects, antiproliferation, cellcycle blockage, and induction of cell apoptosis [26][27][28][29][30], but its antimetastatic effects in osteosarcoma remain unclear. Thus, in this study, we intended to verify whether a low concentration level of matrine exerted anti-invasion effects in osteosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Matrine inhibits the invasive properties of human osteosarcoma cells by downregulating the ERK-NF-κB pathway

Zhang

Zhao

et al. 2014

Anti-Cancer Drugs

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Matrine has been used in anti-inflammatory and anticancer therapies for a long time. However, the antimetastatic effect and molecular mechanism(s) of matrine on osteosarcoma are still unclear. Therefore, the aim of this study was to assess the effects of matrine and related mechanism(s) on osteosarcoma cells. In the study, we found that matrine inhibited the proliferation of osteosarcoma cells in vivo and in vitro and inhibited tumor cell metastasis in vitro at cytotoxic doses. Matrine also decreased the expression of the matrix metalloproteinases-2 and 9, decreased p50 and p65 nuclear translocation, and decreased the phosphorylated level of I-κ-B (IκB)-β. In addition, matrine reduced the phosphorylated levels of extracellular signal-regulated kinase 1/2 proteins, which regulate the invasion of poorly differentiated cancer cells. Finally, when U2OS cells were grown as xenografts in nude mice, intragastric administration of matrine induced a significant dose-dependent decrease in tumor growth. These results show the anticancer properties of matrine, which include the inhibition of invasion and proliferation of human osteosarcoma cells.

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Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF-κB signaling pathway

Cited by 37 publications

References 24 publications

Matrine Suppresses the ER-positive MCF Cells by Regulating Energy Metabolism and Endoplasmic Reticulum Stress Signaling Pathway

Matrine Suppresses the ER-positive MCF Cells by Regulating Energy Metabolism and Endoplasmic Reticulum Stress Signaling Pathway

Anti-tumor activities of active ingredients in Compound Kushen Injection

Matrine inhibits the invasive properties of human osteosarcoma cells by downregulating the ERK-NF-κB pathway

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