Matrine attenuates allergic airway inflammation and eosinophil infiltration by suppressing eotaxin and Th2 cytokine production in asthmatic mice

Huang, Wen‐Chung; Chan, Chiu‐Po; Wu, Sibin; Chen, Li‐Chen; Shen, Jiann-Jong; Kuo, Ming‐Ling; Chen, Mengchun; Liou, Chian-Jiun

doi:10.1016/j.jep.2013.10.065

Cited by 72 publications

(44 citation statements)

References 40 publications

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“…Matrine, a kind of alkaloid component isolated from the roots of Sophora species, has been widely demonstrated to exhibit anti-inflammatory and antioxidant functions in various models [1, 3, 7, 8]. In this study, we found that matrine improved intestinal inflammatory status and antioxidant balance.…”

Section: Discussionsupporting

confidence: 51%

“…Various reports have suggested that matrine exhibits anti-inflammatory and antioxidant effects and may serve as a therapeutic potential for inflammation and oxidative stress relative diseases [2, 3]. For example, matrine alleviates cytokines production, inflammatory cell infiltration, and goblet cell differentiation by downregulating suppressor of cytokine signaling 3 and inhibiting nuclear factor kappa-B (NF-κB) signal in airway epithelial cells and asthmatic mice [4].…”

Section: Introductionmentioning

confidence: 99%

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Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal

Zhou

Zhao³

et al. 2017

Oncotarget

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The aim of this study was to investigate the protective effects of matrine on lipopolysaccharide (LPS)-induced inflammation and oxidative stress in vivo and in vitro. The results showed that matrine improved intestinal inflammatory status and oxidative balance and enhanced chemokine receptor 7 (CCR7) expression. In LPS-challenged mice and Caco-2 cells, matrine alleviated LPS-induced inflammation and oxidative stress via downregulating pro-inflammatory cytokines (IL-1β and IL-17) and malondialdehyde (MDA) production. CCR7-siRNA transfection blocked the protective effects of matrine on LPS-induced inflammation and oxidative stress and exacerbated LPS caused injury. In conclusion, matrine alleviates LPS-induced intestinal inflammation and oxidative stress in mice and Caco-2 cells, which may be associated with CCR7 signal.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal

Zhou

Zhao³

et al. 2017

Oncotarget

View full text Add to dashboard Cite

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“…In addition, Huang et al showed OVA-stimulated eotaxin increasing in the BALF of mice. 25) In our study, there was no difference in eotaxin expression between Der m-treated mice and control mice. However, similar patterns of degranulation after allergen exposure were found in allergic rhinitis and allergic asthma between systemically activated eosinophils and neutrophils.…”

Section: Discussioncontrasting

confidence: 47%

Alleviation of Dermatophagoides microceras-induced allergy by an immunomodulatory protein, FIP-fve, from Flammulina velutipes in mice

Chang

Hsiao

Hung

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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“…Matrine, oxymatrine, sophocarpine and other sophora alkaloids are the main extractable alkaloid components in Sophora flavescens Ait, a Chinese herb. They exhibit various biological activities that comprise anti-cancer, anti-inflammation, antivirus, anti-fibrosis, anti-arrhythmia, and immunosuppressive effects [10][11][12][13][14][15] . However, the clinical potential of the sophora alkaloids remains limited because of their relatively low activities and short half-lives [12,15,16] .…”

Section: Original Articlementioning

confidence: 99%

A novel matrine derivate inhibits differentiated human hepatoma cells and hepatic cancer stem-like cells by suppressing PI3K/AKT signaling pathways

et al. 2016

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Matrine is an alkaloid extracted from a Chinese herb Sophora flavescens Ait, which has shown chemopreventive potential against various cancers. In this study, we evaluated the anticancer efficacy of a novel derivative of matrine, (6aS, 10S, 11aR, 11bR, 11cS)-10- methylamino-dodecahydro- 3a,7a-diazabenzo (de) (MASM), against human hepatocellular carcinoma (HCC) cells and their corresponding sphere cells in vitro and in vivo. Human HCC cell lines (Hep3B and Huh7) were treated with MASM. Cell proliferation was assessed using CCK8 and colony assays; cell apoptosis and cell cycle distributions were examined with flow cytometry. The expression of cell markers and signaling molecules was detected using Western blot and qRT-PCR analyses. A sphere culture technique was used to enrich cancer stem cells (CSC) in Hep3B and Huh7 cells. The in vivo antitumor efficacy of MASM was evaluated in Huh7 cell xenograft model in BALB/c nude mice, which were administered MASM (10 mg·kg·d, ig) for 3 weeks. After the treatment was completed, tumor were excised and weighed. A portion of tumor tissue was enzymatically dissociated to obtain a single cell suspension for the spheroid formation assays. MASM (2, 10, 20 μmol/L) dose-dependently inhibited the proliferation of HCC cells, and induced apoptosis, which correlated with a reduction in Bcl-2 expression and an increase in PARP cleavage. MASM also induced cell cycle arrest in G/G phase, which was accompanied by increased p27 and decreased Cyclin D1 expression. Interestingly, MASM (2, 10, and 20 μmol/L) drastically reduced the EpCAM/CD133 cell numbers, suppressed the sphere formation, inhibited the expression of stem cell marker genes and promoted the expression of mature hepatocyte markers in the Hep3B and Huh7 spheroids. Additionally, MASM dose-dependently suppressed the PI3K/AKT/mTOR and AKT/GSK3β/β-catenin signaling pathways in Hep3B and Huh7 cells. In Huh7 xenograft bearing nude mice, MASM administration significantly inhibited Huh7 xenograft tumor growth and markedly reduced the number of surviving cancer stem-like cells in the tumors. MASM administration also reduced the expression of stem cell markers while increasing the expression of mature hepatocyte markers in the tumor tissues. The novel derivative of matrine, MASM, markedly suppresses HCC tumor growth through multiple mechanisms, and it may be a promising candidate drug for the treatment of hepatocellular carcinoma.

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Matrine attenuates allergic airway inflammation and eosinophil infiltration by suppressing eotaxin and Th2 cytokine production in asthmatic mice

Cited by 72 publications

References 40 publications

Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal

Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal

Alleviation of Dermatophagoides microceras-induced allergy by an immunomodulatory protein, FIP-fve, from Flammulina velutipes in mice

A novel matrine derivate inhibits differentiated human hepatoma cells and hepatic cancer stem-like cells by suppressing PI3K/AKT signaling pathways

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