What moves those of genius and inspires their work is the obsession with the idea that what has already been saying is still not enough. This obsession may be what drove Alexis Carrel (Figure 1) into experimenting on the suturing of blood vessels, after witnessing the assassination of Sadi Carnot, President of the French Republic, who died of a stab wound to the portal vein on June 24, 1894 (Figure 2). Had there been a method of suturing blood vessels, Carrel was convinced he could have saved Sadi Carnot's life. In a series of animal experiments conducted between 1901 and 1910, Alexis Carrel developed the techniques of end-to-end and endto-side anastomosis that we use today.Alexis Carrel, baptized Marie Joseph Auguste Carrel-Billiard, was born in Sainte-Foy-lѐs-Lyon, France on June 28, 1873. His father was a wealthy cloth merchant who died of pneumonia when he, the eldest of three children, was only 5 years old. After having completed his studies with the Jesuits, the young Alexis joined the Faculty of Medicine of the University of Lyon in 1893. After a year of military service, he became an assistant in the Department of Surgery at the University Hospital of Lyon.There, he worked under Mathieu Jaboulay, a prestigious surgeon who pioneered the broad marginal confrontation method (i.e., the "Jaboulay's method") of arterial anastomosis. 1 Carrel was aware that Jaboulay had