Mathematical Optimization Techniques in Computational of Biological Models

Abstract

The aim of this research is focused on the mathematical optimization in computational systems biological models based on find the good method that gives converges faster. Our strategy is to use Bundle Method instead of using Subgradient Methods. Also, we improve the convergence of theoretical properties of the methods. The basic idea of approximation is the subdifferential of the objective function by using subgradients from previous iterations of a bundle method.