Maternally delivered nutritive allergens in cord blood and in placental tissue of term and preterm neonates

Edelbauer, Monika; Loibichler, Christine; Nentwich, Ivo; Gerstmayr, Marianne; Urbanek, R.; Szépfalusi, Zsolt

doi:10.1111/j.1365-2222.2004.01848.x

Cited by 39 publications

(28 citation statements)

References 25 publications

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“…Besides a genetic atopic predisposition, several allergens may also be transferred through the placenta. IgG-dependent as well as IgG-independent route of transfer may play a role, as well as alternative routes such as via placental fibroids, paracellular pathways or also endocytic mechanism (29)(30)(31)(32)(33)(34). In addition, the possibility of primary in vitro T cell responses or crossreactivity, rather than specific activation of previously sensitized T cells is another potential interpretation (17,(35)(36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

Fetal Cord Blood: Aspects of Heightened Immune Responses

Schaub¹,

Tantisira

Gibbons

et al. 2005

J Clin Immunol

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Neonatal immune responses have been associated with the development of atopy in childhood. We assessed in cord blood mononuclear cells (CBMC) whether increased allergen/mitogen-induced lymphoproliferation (LP) is associated with pro-allergic Th2 cytokine IL-13 or Th1 cytokine IFN-γ secretion. We determined whether LP to one allergen is related to heightened lymphocyte function to other allergens/mitogen. CBMC from 135 neonates were stimulated with house dust mite (Derf1), cockroach, ovalbumin, or mitogen. LP to one allergen was associated with significantly increased LP to other allergens/mitogen. Increased Derf1-LP was associated with increased Derf1-induced IL-13 secretion (r = 0.21, p = 0.01). After adjusting for neonatal gender, race, and maternal smoking, Derf1-LP remained associated with Derf1-IL-13 (OR 3.08, 95% CI 1.56-6.10). Increased mitogeninduced proliferation was associated with increased mitogen-induced IL-13 secretion (r = 0.37, p < 0.001). For some individuals, a predisposition to a heightened immune response is already evident at birth. Whether this phenotype results in atopy in childhood warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

Fetal Cord Blood: Aspects of Heightened Immune Responses

Schaub¹,

Tantisira

Gibbons

et al. 2005

J Clin Immunol

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“…Maternally delivered nutritive allergens, such as ovalbumin and b-lactoglobulin can be detected in cord blood and placental tissue [21], and foetal cord blood mononuclear cell reactivity to these agents has also been observed [22]. During pregnancy, there is a polarisation of T helper cells towards a dominance of Th2 in mother and foetus [23].…”

Section: Introductionmentioning

confidence: 99%

Does hapten exposure predispose to atopic disease? The hapten-atopy hypothesis

McFadden

White

Basketter

et al. 2009

Trends in Immunology

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“…In utero sensitization to environmental antigens has been suggested, specifically to house dust mite, cow's milk and hen's egg. Such reactivity supports the contention that fetal exposure occurs to both dietary and inhalant allergens [73,74]. Although different routes of sensitization are possible during fetal life, IECs remain an important port of entry for antigens present in the amniotic fluid.…”

Section: Amniotic-and Milk-mediated Regulation Of Intestinal Immunitymentioning

confidence: 54%

Intestinal epithelial barrier and mucosal immunity

Rumbo

Schiffrin

2005

CMLS, Cell. Mol. Life Sci.

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Intestinal mucosa integrates primary digestive functions with immune functions such as pathogen surveillance, antigen transport and induction of mucosal immunity and tolerance. Intestinal adaptive immunity is elicited in organized mucosa-associated lymphoid tissue (O-MALT) that is composed of antigen-presenting cells and lymphocytes and achieved by effector cells widely distributed in mucosa (diffuse MALT or D-MALT). Interaction between the intestinal epithelium, the O-MALT and the diffuse MALT plays a critical role in establishing an adequate immune response. In regions associated to O-MALT, lympho-epithelial cross-talks lead to acquisition of a specific epithelial phenotype that contributes to O-MALT organization and functionality. Beyond the expression of several innate immune functions, the intestinal epithelium may directly take up and present antigens due to the expression of major histocompatibility complex (MHC) and MHC-related molecules. A complex genetic program that will be outlined in the present review controls the development of immune functions of the intestinal epithelium. The effect of environmental signals on the modulation of this ontogenetic program during development and neonatal life, from bioactive components of amniotic fluid to lactation and bacterial colonization, will be discussed.

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Maternally delivered nutritive allergens in cord blood and in placental tissue of term and preterm neonates

Abstract: These findings provide direct evidence for the release of tiny amounts of nutritive allergens from placental tissue indicating diaplacental allergen transfer and fetal exposure to nutritive allergens in vivo.

Cited by 39 publications

References 25 publications

Fetal Cord Blood: Aspects of Heightened Immune Responses

Fetal Cord Blood: Aspects of Heightened Immune Responses

Does hapten exposure predispose to atopic disease? The hapten-atopy hypothesis

Intestinal epithelial barrier and mucosal immunity

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