Maternal vitamin D status during pregnancy and risk of childhood asthma: A meta‐analysis of prospective studies

Song, Hui; Yang, Lei; Jia, Chongqi

doi:10.1002/mnfr.201600657

Cited by 29 publications

(55 citation statements)

References 46 publications

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“…A spectrum of all possible associations has accrued, demonstrating no association (53–57), an inverse (58–61), a U -curved (62, 63), and even a direct relationship (64, 65) between the two entities. In accordance, systematic reviews and meta-analyses on these birth cohort studies reproduced inconclusive evidence, revealing no association with asthma or wheezing (66), a U -shaped association with a lower risk of childhood asthma at maternal 25(OH)D levels of 30 ng/ml (70 nmol/l) (67) and a borderline significant inverse relationship (68). …”

Section: Maternal Vitamin D Status and Associations With Asthma In Eamentioning

confidence: 83%

Can Getting Enough Vitamin D during Pregnancy Reduce the Risk of Getting Asthma in Childhood?

2017

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The worldwide increase in asthma prevalence during the last decades and the re-emergence of vitamin D deficiency in many populations hinted toward an underlying association between these two conditions. Since asthma is presented with high incidence in childhood and neonatal vitamin D stores depend on maternal vitamin levels, a possible programming effect of maternal vitamin D status during gestation was suggested. Observational and longitudinal studies on this subject led to inconclusive results with glimmer of positivity. In the randomized controlled clinical trials (RCTs) that followed, increased doses of vitamin D were tested in pregnant women being at high risk of having an asthmatic child. Although, the results of RCTs showed a potential association with asthma-related phenotypes rather than asthma per se, the low toxicity of vitamin D supplements make it tempting to speculate that pregnant women at a high risk of obtaining a child with asthma may be benefited, especially if they are vitamin D deficient.

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Section: Maternal Vitamin D Status and Associations With Asthma In Eamentioning

confidence: 83%

Can Getting Enough Vitamin D during Pregnancy Reduce the Risk of Getting Asthma in Childhood?

2017

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“…Two other meta-analyses showed a trend to increased 25(OH)D to be inversely associated with the risk of asthma and wheeze during childhood, although associations did not reach statistical significance [50,93]. Another meta-analysis based on 12 prospective studies suggested even a more complex association, in which a U-shaped relationship between maternal 25(OH)D levels and risk of asthma was described [49]. A more recent study meta-analyzing the results from 14 observational studies found no association between prenatal vitamin D concentrations and risk of asthma during childhood (Pacheco-Gonzalez et al submitted [94]).…”

Section: Prenatal Vitamin D Status and Asthma Riskmentioning

confidence: 99%

“…Observational studies have associated lower maternal 25(OH)D serum levels with higher risk of preeclampsia, gestational diabetes, caesarean sections, preterm birth (PTB) or IUGR [47,48]. In addition, there is growing evidence on the association with offspring risk of asthma, bone health, allergies and impaired neurodevelopment [49][50][51][52].…”

Section: Vitamin D Supplementation During Pregnancy and Perinatal Outmentioning

confidence: 99%

“…The levels of prenatal vitamin D on wheeze/asthma susceptibility in offspring have been extensively investigated in observational studies [49,50,91,92]. There are two meta-analyses that have shown high dietary vitamin D intake during pregnancy to be associated with a reduced risk of wheeze in the offspring (Nurmatov et al [91] OR 0.56, 95% CI 0.42-0.73; Beckhaus et al [92] OR 0.58, 95% CI 0.38-0.88).…”

Section: Prenatal Vitamin D Status and Asthma Riskmentioning

confidence: 99%

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Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Larqué

Morales

Leis³

et al. 2018

Ann Nutr Metab

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Background: To what extent does the circulating 25-hydroxyvitamin D (25[OH]D) concentration help to meet the physiological needs of humans is an ongoing subject of debate. Remaining unexposed to the sun to reduce melanoma cancer risk, current lifestyle with less out door activities, and increasing obesity rates, which in turn increases the storage of vitamin D in the adipose tissue, are presumably factors that contribute to the substantial upsurge in the prevalence of vitamin D deficiency in humans. Since evidence is lacking regarding the appropriate cut-off points to define vitamin D status during pregnancy, references used to establish the intake recommendations and vitamin D content of prenatal vitamin supplements are quite conservative. Summary: The foetus depends fully on maternal 25(OH)D supply. 25(OH)D readily crosses the placenta and it is activated into 1,25(OH)₂D by foetal kidneys. Moreover, 1,25(OH)₂D can also be synthesized within the placenta to regulate placental metabolism. The importance of vitamin D during pregnancy for maintaining maternal calcium homeostasis and therefore for foetal bone development is well recognized; major discussions are in progress regarding the potential maternal detrimental effects on pregnancy outcomes, foetal development, and the long-term health of children. Interventional studies have also evaluated the effect of vitamin D for reduction on preterm birth and asthma programming. Key Messages: Clinically, by understanding the effects of vitamin D on perinatal outcomes, we could individualize antenatal counselling regarding vitamin D supplementation to ensure vitamin D repletion without increasing the risk of foetal hypercalcemia.

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“…[12] In the Generation R Study, Gazibara et al [13] found that maternal vitamin D levels did not correlate with asthma, but low levels of 25(OH)D 3 at birth in infants were associated with higher airway resistance in childhood. In a recent meta-analysis of 15 prospective studies, Song et al [14] suggested there may be a U-shaped association between maternal 25(OH)D 3 levels and asthma, with the lowest risk of asthma at approximately 70 nmol/L of 25(OH)D 3 .…”

Section: Asthma and Vitamin D Levelsmentioning

confidence: 99%

Vitamin D in respiratory diseases

Mahomed

2017

S Afr Res J

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REVIEWVitamin D has traditionally been known for its role in bone homeostasis with its effects on calcium and phosphate absorption and secretion. However, new evidence is emerging of its effects on a number of other cells, especially the immune system. This article reviews the role of vitamin D as it pertains to the respiratory tract and respiratory diseases. Respir J 2017;23 (1) Vitamin D belongs to a group of fat-soluble secosteroids and is required for intestinal absorption of calcium (Ca 2+ ) and phosphate (PO 4 3-). In humans, vitamin D is present as ergocalciferol (vitamin D 2 ) or cholecalciferol (vitamin D 3 ), and both forms can be ingested from the diet and/or supplements. The body can also synthesise vitamin D from cholesterol when sun exposure is adequate, hence it has been nicknamed the 'sunshine vitamin' . [1] Recently, interest has grown in the role of vitamin D in many non-skeletal medical conditions, including respiratory infection and lung function. [2] Emerging evidence indicates that vitamin D-mediated innate immunity is important in host defences against respiratory tract pathogens. [3] Observational studies suggest that vitamin D deficiency increases the risk of respiratory infections, incident wheezing illness in children and adults, and can cause asthma exacerbations. Vitamin D also modulates regulatory T-cell function and interleukin-10 (IL-10) production, which may increase the therapeutic response to glucocorticoids in steroid-resistant asthma. S Afr HistoryIn 1914, American researchers McCollum and Davis discovered a substance in cod liver oil which was later called 'vitamin A' . In 1922, McCollum tested modified cod liver oil in which the vitamin A had been denatured. The modified oil cured rickets in sick dogs, so McCollum concluded the factor in cod liver oil that cured rickets was distinct from vitamin A. He called it vitamin D because it was the fourth vitamin to be named. [4] In 1923, American biochemist Harry Steenbock demonstrated that the irradiation of foodstuffs, especially milk, led to a cure for rickets. In 1932, an academic collaboration between Bourdillon, Rosenheim, King and Callow led to the isolation and characterisation of vitamin D and later in the 1930s, Windaus further clarified the chemical structure of vitamin D. By 1972, Holick had discovered that vitamin D was metabolised to two active forms, i.e. calcidiol and calcitriol. [5,6] Recommended dietary allowance of vitamin DThe US Institute of Medicine (IOM) recommended dietary allowance of vitamin D is 400 international units (IU) per day for children younger than 1 year of age, 600 IU per day for children at least 1 year of age and adults up to 70 years, and 800 IU per day for older adults.The US IOM concluded that serum 25-hydroxyvitamin D (25(OH)D) of 20 ng/mL or more would cover the requirements of 97.5% of the population. [7] The US Endocrine Society's Clinical Practice Guidelines suggest that 400 -1 000 IU/day may be needed for children aged <1 year, 600 -1 000 IU/day for children aged ≥1 year, and 1 500 ...

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Maternal vitamin D status during pregnancy and risk of childhood asthma: A meta‐analysis of prospective studies

Abstract: This dose-response meta-analysis suggested a U-shaped relationship between maternal blood 25(OH)D levels and risk of childhood asthma. Further studies are needed to confirm the association.

Cited by 29 publications

References 46 publications

Can Getting Enough Vitamin D during Pregnancy Reduce the Risk of Getting Asthma in Childhood?

Can Getting Enough Vitamin D during Pregnancy Reduce the Risk of Getting Asthma in Childhood?

Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Vitamin D in respiratory diseases

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