Can Getting Enough Vitamin D during Pregnancy Reduce the Risk of Getting Asthma in Childhood?

Bountouvi, Evangelia; Douros, Konstantinos; Papadopoulou, Anna

doi:10.3389/fped.2017.00087

Cited by 5 publications

(5 citation statements)

References 89 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitamin D supplementation, in both pregnancy and lactation, appeared to reduce the risk of FPIAP, and other researchers report that it protects against asthma and FA in the offspring ( 55 , 56 ). Inadequate levels of vitamin D in infants have been associated with clinical manifestations of cow's milk allergy, including non-IgE forms ( 57 ), and the role of vitamin D in the prevention of FA ( 58 ) and other atopic disease is documented ( 55 , 56 , 59 ).…”

Section: Discussionmentioning

confidence: 88%

Food Protein-Induced Allergic Proctocolitis: The Effect of Maternal Diet During Pregnancy and Breastfeeding in a Mediterranean Population

et al. 2022

View full text Add to dashboard Cite

BackgroundThe aim of the current investigation was to explore the association of food protein-induced allergic proctocolitis (FPIAP) with the maternal diet during pregnancy and breastfeeding in Greek infants.MethodsA multicenter retrospective case-control study was conducted in 6 regions in Greece, with 96 mothers of infants with and 141 mothers of infants without a history of FPIAP. Maternal dietary habits during pregnancy and breastfeeding were evaluated with the following validated questionnaires: (a) The Mediterranean Diet Score and (b) The Mediterranean Oriented Culture-Specific Semi-Quantitative Food Frequency Questionnaire.ResultsFPIAP was associated with cow's milk (83.6%), egg (7.3%), wheat (6.4%), and beef (6.4%) in the maternal diet. Adherence to Mediterranean Diet was similar among the mothers. Mothers of FPIAP infants consumed more vegetables. Elastic net prediction models showed that, in this Mediterranean population, increased consumption during pregnancy and lactation of common allergens, whole grain products, homemade food, fish and shellfish, and fruits was associated with a decreased risk of FPIAP. Conversely, a high intake of vegetables, sugar and total fat, and non-stick/grilled cooking, were associated with increased risk of FPIAP, as was a high intake of salt and white flour during lactation only.ConclusionsComponents of a maternal Mediterranean Diet may protect against FPIAP when traditional cooking methods are adopted and fish, fruit, and whole wheat products are consumed frequently during pregnancy and breastfeeding.

show abstract

Section: Discussionmentioning

confidence: 88%

Food Protein-Induced Allergic Proctocolitis: The Effect of Maternal Diet During Pregnancy and Breastfeeding in a Mediterranean Population

et al. 2022

View full text Add to dashboard Cite

show abstract

“…• observational: generally favorable on bronchial outcomes [12,13,[149][150][151][152][153] • interventional: favorable when mother has asthma [154][155][156] Postnatal…”

Section: Postnatalmentioning

confidence: 99%

“…Vitamin D supplements and the fortification of foods, such as bread, cereals, and dairy products, are proposed to ensure adequate intake [224]. Epidemiological findings regarding high prenatal maternal levels of vitamin D are conflicting, supporting in general, but not consistently [12,13], a favorable effect on bronchial outcomes in the offspring, but not necessarily asthma [149,150]. Recently, Jensen and colleagues reported an association of low serum levels of total 25-hydroxyvitamin-D[(25(OH)D] in pregnant women with asthma with a greater risk of adverse respiratory outcomes in the offspring at 12 months [151].…”

Section: The Antioxidant Hypothesismentioning

confidence: 99%

Mediterranean-Type Diets as a Protective Factor for Asthma and Atopy

2022

View full text Add to dashboard Cite

We are currently riding the second wave of the allergy epidemic, which is ongoing in affluent societies, but now also affecting developing countries. This increase in the prevalence of atopy/asthma in the Western world has coincided with a rapid improvement in living conditions and radical changes in lifestyle, suggesting that this upward trend in allergic manifestations may be associated with cultural and environmental factors. Diet is a prominent environmental exposure that has undergone major changes, with a substantial increase in the consumption of processed foods, all across the globe. On this basis, the potential effects of dietary habits on atopy and asthma have been researched rigorously, but even with a considerable body of evidence, clear associations are far from established. Many factors converge to obscure the potential relationship, including methodological, pathophysiological and cultural differences. To date, the most commonly researched, and highly promising, candidate for exerting a protective effect is the so-called Mediterranean diet (MedDi). This dietary pattern has been the subject of investigation since the mid twentieth century, and the evidence regarding its beneficial health effects is overwhelming, although data on a correlation between MedDi and the incidence and severity of asthma and atopy are inconclusive. As the prevalence of asthma appears to be lower in some Mediterranean populations, it can be speculated that the MedDi dietary pattern could indeed have a place in a preventive strategy for asthma/atopy. This is a review of the current evidence of the associations between the constituents of the MedDi and asthma/atopy, with emphasis on the pathophysiological links between MedDi and disease outcomes and the research pitfalls and methodological caveats which may hinder identification of causality. MedDi, as a dietary pattern, rather than short-term supplementation or excessive focus on single nutrient effects, may be a rational option for preventive intervention against atopy and asthma.

show abstract

“…This may be due to high vitamin D levels having a negative impact on lung function. Some studies have also found that vitamin D interventions had no other advantageous changes ( 16 , 31 ). One possible explanation for the adverse effect of vitamin D on asthmatic children is their high baseline levels, which may leave little room for improvements in lung function.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin D Supplementation in Children With Asthma: A Meta-Analysis

Hao

Luo

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

BackgroundAn increasing number of studies have suggested that vitamin D can be used to treat childhood asthma, but its clinical effects are still unclear. We conducted this meta-analysis to examine the latest estimates of the effectiveness and safety of using vitamin D to treat childhood asthma.MethodsThe PubMed, The Cochrane Library, ScienceDirect, Embase, Scopus, Ovid MEDLINE, Web of Science, and Google Scholar databases were searched for randomized controlled trials (RCTs) describing vitamin D supplementation interventions for asthmatic children. Asthma exacerbation, vitamin D levels, the predicted percentage of forced expiratory volume in the first second (FEV1%) and adverse effects (AEs) were analyzed as the main outcome measures.ResultsAfter screening, eight RCTs with 738 children were included. Compared with placebos, vitamin D supplementation had a stronger effect on serum vitamin D levels [mean difference (MD) = 13.51 (4.24, 22.79), p = 0.004]. The pooled results indicated that no significant changes were found between the groups in asthma control, as measured by adopting the following indicators: asthma exacerbation [risk ratio (RR) = 0.92 (0.68, 1.25), p = 0.60]; Childhood Asthma Control Test (CACT) scores [MD = 0.15 (−0.43, 0.74), p = 0.61]; hospitalizations for asthma exacerbation [RR = 1.20 (0.48, 2.96), p = 0.70]; acute care visits [RR = 1.13 (0.77, 1.65), p = 0.63]; steroid use [RR = 1.03 (0.41, 2.57), p = 0.95]; and fractional exhaled nitric oxide (FeNO) [MD =-3.95 (−22.87, 14.97), p = 0.68]. However, vitamin D supplementation might reduce the FEV1% [MD = −4.77 (−9.35, −0.19), p = 0.04] and the percentage of predicted forced vital capacity (FVC%) [MD =-5.01 (−9.99, −0.02), p = 0.05] in patients. Subgroup analysis revealed no difference in AEs between the two groups.ConclusionsVitamin D supplementation significantly increased patients' serum vitamin D levels, but it had no benefit for asthma control. However, vitamin D supplementation might reduce patients' lung function. It is essential to systemically search for more large-scale, rigorous, and well-designed RCTs to fully confirm these conclusions.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021288838, PROSPERO CRD42021288838.

show abstract

Can Getting Enough Vitamin D during Pregnancy Reduce the Risk of Getting Asthma in Childhood?

Cited by 5 publications

References 89 publications

Food Protein-Induced Allergic Proctocolitis: The Effect of Maternal Diet During Pregnancy and Breastfeeding in a Mediterranean Population

Food Protein-Induced Allergic Proctocolitis: The Effect of Maternal Diet During Pregnancy and Breastfeeding in a Mediterranean Population

Mediterranean-Type Diets as a Protective Factor for Asthma and Atopy

The Effect of Vitamin D Supplementation in Children With Asthma: A Meta-Analysis

Contact Info

Product

Resources

About