Maternal Vitamin D Status Determines Bone Variables in the Newborn

Viljakainen, Heli; Saarnio, Elisa; Hytinantti, Timo; Miettinen, Maija E.; Surcel, Heljä‐Marja; Mäkitie, Outi; Andersson, Sture; Laitinen, Kalevi; Lamberg‐Allardt, Christel

doi:10.1210/jc.2009-1391

Cited by 244 publications

(218 citation statements)

References 46 publications

Supporting

Mentioning

197

Contrasting

Unclassified

Order By: Relevance

“…To evaluate the possible degradation of 25(OH)D during storage, we compared samples that had been stored for 10-13 and 14-17 years and found no difference in mean 25(OH) D concentrations. In another study using more recently collected FMC serum samples (less than 2 years before the analysis) [15], the mean 25(OH)D concentration was lower (41.0 nmol/l) than in the present study, where the samples had been stored and analysed by the same method in the same laboratory.…”

Section: Discussioncontrasting

confidence: 83%

See 1 more Smart Citation

Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring

et al. 2012

Self Cite

View full text Add to dashboard Cite

Aims/hypothesis Vitamin D deficiency during the fetal period or infancy is one of the suggested environmental factors for type 1 diabetes and for its increasing incidence. To test this hypothesis we compared serum 25-hydroxyvitamin D (25(OH)D) levels during early pregnancy in mothers of children who subsequently developed type 1 diabetes (case mothers) with mothers of non-diabetic healthy children (control mothers) of the same age. Methods Children with type 1 diabetes were identified from the nationwide prescription register. 25(OH)D concentration was measured from serum samples collected during the first trimester of pregnancy from all Finnish women (Finnish Maternity Cohort). A total of 343 case mothers and 343 control mothers were included in the study. Samples were collected throughout the year. Samples from case and control mothers were matched on the day of collection. Results Mean 25(OH)D levels in case mothers (43.9 nmol/l) and control mothers (43.7 nmol/l) were not different. Of all mothers, 481 (70.1%) were vitamin D-deficient or -insufficient. Conclusions/interpretation No difference was found in serum 25(OH)D concentrations during first trimester of pregnancy between mothers whose children later on developed type 1 diabetes, and mothers of non-diabetic ' healthy' children of the same age. It is difficult to detect possible effects of mothers' vitamin D deficiency during early pregnancy on the development of type 1 diabetes in the offspring in this population, as such a large proportion of mothers were vitamin D-deficient or -insufficient.

show abstract

Section: Discussioncontrasting

confidence: 83%

“…In another study [15], the 25(OH)D levels of Finnish women were somewhat higher postpartum than during the first trimester of pregnancy, possibly indicating that an increased number of women use recommended vitamin D supplements during the last trimester than during the first trimester of pregnancy.…”

Section: Discussionmentioning

confidence: 91%

Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…1,2 Pregnant and lactating women and their newborn infants are at a high risk of vitamin D deficiency. [3][4][5][6][7][8][9][10][11][12] Vitamin D is involved in skeletal homeostasis during pregnancy. 13,14 Severe vitamin D deficiency with profound hypocalcemia may lead to seizures in neonates, and has also been associated with low birth weight, prenatal death, preeclampsia and an increased risk of primary cesarean section.…”

Section: Introductionmentioning

confidence: 99%

Maternal and infant vitamin D status during the first 9 months of infant life—a cohort study

et al. 2013

View full text Add to dashboard Cite

BACKGROUND/OBJECTIVES: The objective of this study was to assess vitamin D status and possible consequences of low plasma 25-hydroxyvitamin D (25OHD) levels in a population of healthy mothers and their infants. SUBJECTS/METHODS: A total of 107 women aged 24-41 years gave birth to 108 infants. They were followed up three times during 9 months. RESULTS: Cord blood 25OHD level (43.3 ± 20.4 nmol/l) on average was 62 ± 16% of maternal levels (73.3 ± 30.7 nmol/l), measured 1-2 weeks postpartum. Cord blood 25OHD correlated positively with maternal 25OHD levels (r ¼ 0.83, Po0.001). At birth, 23% of mothers and 61% of infants had 25OHD o50 nmol/l. Vitamin D deficiency (25OHDo25 nmol/l) was present in 66% of the children born by mothers with 25OHD levels below 50 nmol/l (Po0.01), whereas only one child was born with deficiency among mothers with 25OHD 450 nmol/l. During follow-up, most of the children (485%) had 25OHD levels 450 nmol/l, which most likely was attributable to the use of supplements, as more than 95% of the children were given daily vitamin D supplements of 10 mg of vitamin D. Cord blood parathyroid hormone levels were very low (median 0.21; interquartile range 0.11-0.33 pmol/l), with increasing levels (Po0.01) reaching 3.08 (2.67-3.92 pmol/l) at the last visit. Vitamin D levels were not associated with anthropometric indices of the newborn infant or their growth during follow-up. CONCLUSIONS: Vitamin D deficiency is widespread in newborn. Maternal 25OHD levels above 50 nmol/l are needed to prevent vitamin D deficiency among newborn.

show abstract

“…There can be some calcium loss during pregnancy through fetal demands and increased urinary calcium excretion, which increases with advancing pregnancy. Throughout gestation, if a woman is Vit D deficient, it appears to impact fetal bone health more than maternal health [4][5][6]. There are different deficiency levels.…”

Section: Vit D and Pregnancymentioning

confidence: 99%

The Emerging Role of Vitamin D3 in Women’s Health

Khadilkar

2013

J Obstet Gynecol India

View full text Add to dashboard Cite

Maternal Vitamin D Status Determines Bone Variables in the Newborn

Cited by 244 publications

References 46 publications

Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring

Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring

Maternal and infant vitamin D status during the first 9 months of infant life—a cohort study

The Emerging Role of Vitamin D3 in Women’s Health

Contact Info

Product

Resources

About