Maternal Vitamin D Levels in Gestation - An Observational Cross Sectional Study in the Rural Population of South India

Amalraj, Julie Christy; Andal,; Srinivasan, P. Bala; Dorairaj, Swayam Jothi; Sumathy, Govindarajan

doi:10.23958/ijirms/vol04-i08/738

Cited by 1 publication

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“…This increases chances of the pregnant women acquiring the COVID-19 infections. First trimester calcidiol and calcitriol levels are reduced when compared to the second and third trimester levels [2].…”

Section: Discussionmentioning

confidence: 90%

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COVID-19 Infections and Vitamin D Deficiency in Pregnancy

Christy¹,

Srinivasan²,

Ravi³

2021

JCIM

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Corona virus disease COVID-19 has been a global health threat since November 2019. It has been reported as 6 th cause of global public health emergency by World Health Organisation on January 2020. Serum cholecalciferol or calcidiol is the prime marker for the vitamin D status of a person. It has also been gaining importance in prevention of COVID-19 disease severity. Vitamin D has proven cellular level modulation in both the adaptive and innate immune system through cytokines and regulation of cell signalling pathways. This vitamin has been observed to be lower than the optimal levels in pregnancy. The foetal demand for the vitamin increases during the early embryogenesis hence it is reported lowest in the first trimester. It has been noted to increase gradually during second trimester and reaches sufficient limits in third trimester. There is a compensation of serum cholecalciferol levels in third trimester due to the placental secreting receptors. This review analyses the immunomodulatory property of serum cholecalciferol and its effect on T regulatory cell count which is the predicting tool for disease severity in COVID-19.

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Section: Discussionmentioning

confidence: 90%

“…Pregnancy is an altered physiological condition. The circulating levels of 25 hydroxycholecalciferol levels are reported to be very low throughout pregnancy [1,2]. 25 hydroxy cholecalciferol levels in known to affect bone health as well as maternal immunity against infections.…”

Section: Introductionmentioning

confidence: 99%