Maternal vitamin D in pregnancy and offspring bone measures in childhood: The Vitamin D in Pregnancy study

Hyde, Natalie K.; Brennan-Olsen, Sharon; Mohebbi, Mohammadreza; Wark, John D.; Hosking, Sarah; Pasco, Julie A.

doi:10.1016/j.bone.2019.04.013

Cited by 14 publications

(12 citation statements)

References 24 publications

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“…Six studies found no association between maternal vitamin D status and bone parameters from the neonatal period even to the age of 26 years [ 23 , 35 , 36 , 37 , 38 , 39 ]. In the four remaining studies, positive associations were found between maternal vitamin D status and offspring BMD [ 18 , 40 ], with sex-specific association in one study [ 41 ], as well as neonatal bone SOS [ 42 ].…”

Section: Findings and Discussionmentioning

confidence: 99%

“…In all of the included studies on maternal vitamin D status, authors assessed 25(OH)D concentrations [ 17 , 18 , 23 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. In addition, in one study, 1,25(OH) 2 D concentrations were also assessed and its levels were similar across different levels of 25(OH)D [ 23 ].…”

Section: Findings and Discussionmentioning

confidence: 99%

“…In total, the results of 49 studies were summarized in the presented review ( Table S3 ). Maternal vitamin D status and birth anthropometry were assessed in the most studies, 11 [ 17 , 18 , 23 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ] and 15 [ 10 , 23 , 24 , 31 , 42 , 53 , 54 , 56 , 62 , 63 , 64 , 65 , 70 , 71 , 72 ], respectively. However, factors that seem to be the most relevant in terms of BMD are dietary intake, other than vitamin D nutrients status, and gestational age, as the plurality of the studies showed positive associations.…”

Section: Findings and Discussionmentioning

confidence: 99%

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Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

2021

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There is growing evidence that bone health may be programmed in the first years of life. Factors during the prenatal period, especially maternal nutrition, may have an influence on offspring’s skeletal development and thus the risk of osteoporosis in further life, which is an increasing societal, health and economic burden. However, it is still inconclusive which early life factors are the most important and to what extent they may affect bone health. We searched through three databases (PubMed, Google Scholar, Cochrane Library) and after eligibility criteria were met, the results of 49 articles were analyzed. This narrative review is an overall summary of up-to-date studies on maternal diet, nutritional status, and birth-related factors that may affect offspring bone development, particularly bone mineral density (BMD). Maternal vitamin D status and diet in pregnancy, anthropometry and birth weight seem to influence BMD, however other factors such as subsequent growth may mediate these associations. Due to the ambiguity of the results in the analyzed studies, future, well-designed studies are needed to address the limitations of the present study.

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Section: Findings and Discussionmentioning

confidence: 99%

Section: Findings and Discussionmentioning

confidence: 99%

Section: Findings and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

2021

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“…29 ► Positively associated with bone mineral density of the spine and total body at 11 years in boys but not in girls. 30 ► Negatively associated with total fat mass pecentage and positively associated with total lean mass percentage at 11 years in offspring whose mothers also smoked. 31 ► Positively associated with trabecular bone scores at 11 years in boys, but not girls.…”

Section: Findings To Datementioning

confidence: 99%

“…Positively associated with bone mineral density of the spine and total body at 11 years in boys but not in girls. 30 …”

Section: Findings To Datementioning

confidence: 99%

The Vitamin D in Pregnancy Study: a prospective prebirth cohort in southern Australia

et al. 2020

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PurposeThe Vitamin D in Pregnancy Study is a long-term ongoing cohort study. It was conceived to explore relationships between maternal vitamin D status in pregnancy and offspring growth and development, and has since diversified to include a wide range of physical and mental health exposures and outcomes.ParticipantsRecruitment was from the University Hospital Geelong (Barwon Health) antenatal clinic, Geelong, Victoria, Australia, between 2002 and 2004. 475 women were initially recruited, which resulted in 400 eligible mother–child pairs at birth.Findings to dateThe cohort has been followed up twice in pregnancy, at birth, and 1 year, 6 years and 11 years post birth. The study has reported an association between vitamin D in pregnancy and musculoskeletal health and body composition in the children.Future plansSubject to funding, there will be a prospective young adult follow-up. This profile aims to foster both cross-national and international collaborations with both existing and future data collection.

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Gestational Vitamin D and Offspring Bone Measures: Is the Association Independent of Maternal Bone Quality?

et al. 2020

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Maternal vitamin D in pregnancy and offspring bone measures in childhood: The Vitamin D in Pregnancy study

Cited by 14 publications

References 24 publications

Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

The Vitamin D in Pregnancy Study: a prospective prebirth cohort in southern Australia

Gestational Vitamin D and Offspring Bone Measures: Is the Association Independent of Maternal Bone Quality?

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