The Vitamin D in Pregnancy Study: a prospective prebirth cohort in southern Australia

Hyde, Natalie K.; Brennan-Olsen, Sharon; Wark, John D.; Hosking, Sarah; Vuillermin, Peter; Williams, Lana J.; Pasco, Julie A.

doi:10.1136/bmjopen-2019-036003

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…There is some evidence to suggest that childhood outcomes may be differential by the timing of exposure to low vitamin D levels. [36][37][38][39] Failure to detect and treat deficiency until 24 weeks will likely have implications for those pregnancy and foetal health outcomes that have been found to be improved by higher 25(OH)D levels in early pregnancy. In addition, there will be a lag in improving levels from the time of intervention (i.e.…”

Section: Discussionmentioning

confidence: 99%

Demographic and clinical predictors of vitamin D status in pregnant women tested for deficiency in Western Australia

Miller

Klerk

Davis

et al. 2021

Australian and New Zealand Journal of Public Health

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public pathology service and to examine whether there were additional indications to those currently recommended that were important predictors of vitamin D deficiency among those women. Methods Study setting, design and populationWestern Australia covers approximately 2.5 million km 2 spanning a latitude range of 10.5-35.5° South latitude. The distribution of the population is highly centralised, with the majority (79%) residing in the capital city, Perth, in the state's south-west. The remaining

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Section: Discussionmentioning

confidence: 99%

Demographic and clinical predictors of vitamin D status in pregnant women tested for deficiency in Western Australia

Miller

Klerk

Davis

et al. 2021

Australian and New Zealand Journal of Public Health

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“…Data were collected as part of the Vitamin D in Pregnancy (VIP) study, a longitudinal observational mother–child pair cohort study based in Geelong, southeastern Australia [ 15 ]. The methods for this study have been reported previously [ 12 ].…”

Section: Methodsmentioning

confidence: 99%

Gestational vitamin D and offspring fracture risk: do associations persist into mid adolescence?

Percival,

Anderson,

Pasco

et al. 2024

Eur J Clin Nutr

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Background Previous studies report that maternal vitamin D exposure during pregnancy is associated with offspring later-life bone health. A study in the Vitamin D in Pregnancy (VIP) cohort reported sexually dimorphic effects of maternal 25-hydroxyvitamin-D (25(OH)D) and offspring fracture profiles at 10 years of age. We, therefore, aimed to determine associations between maternal 25(OH)D status and offspring fracture risk at 16 years of age in this cohort. Methods In total, 475 mother-child pairs were recruited to the VIP study in southeastern Australia. Maternal serum samples were obtained at recruitment (<16 weeks’ gestation) and/or 28–32 weeks’ gestation and analysed for 25(OH)D. Radiologically-confirmed incident fractures in children were ascertained from date of birth (2002–2004) until July 16, 2019. Cox proportional hazard models were used to determine associations between maternal 25(OH)D and childhood fracture risk, and final models included maternal age at recruitment, offspring sex, birth weight, gestation length and season of 25(OH)D sample. Results Data were available for 400 children (mean age 16.1 years). There were 122 (30.5%) children who sustained at least one fracture. Higher maternal 25(OH)D (per 10 nmol/L) in early gestation was associated with a decreased fracture risk in boys (HR 0.87; 95% CI: 0.77, 0.99); the pattern was reversed in girls (HR 1.10; 95% CI 1.00, 1.22). At late gestation, higher maternal 25(OH)D was associated with an increased fracture risk in girls (HR 1.14; 95% CI: 1.04, 1.24). Conclusions While our findings must be interpreted within the constraints of our limitations, we report that the contradictory risk profiles observed at early childhood in this cohort remain in adolescence.

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“…Where data-sharing policies were mentioned in publications, studies said data could be made available upon reasonable request to the authors (65,85,108,109). Through reviewing study websites, we were able to identify data access procedures for 7 of the 56 cohorts, including the ALSPAC (88), Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) (110), CHAMACOS (107), DNBC (57), MoBa (105), SGA (106), and the Vitamin D in Pregnancy Cohort (111).…”

Section: Sample Collection and Availabilitymentioning

confidence: 99%

The landscape of pregnancy and prepregnancy cohorts: a scoping review

Maxwell,

Gilyan,

Chavan

et al. 2024

Preprint

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Background Recent research in life course epidemiology has demonstrated the importance of evaluating how prepregnancy and pregnancy exposures affect later life developmental outcomes. In this scoping review, we identified and described completed or ongoing pregnancy and prepregnancy cohorts to assess gaps in the maternal exposures and child outcomes measured in these initiatives and inform future research investments. Methods We developed a systematic search that included text and MeSH terms and was tailored for four biomedical citation databases. We applied the Arskey and O’Malley scoping review methodology. We selected a scoping review methodology to provide a comprehensive overview of pregnancy and prepregnancy cohorts and their characteristics. Two reviewers independently conducted the title, abstract, full-text screening, and data charting; a third reviewer resolved discrepancies. The results were summarised in narrative form. Results We reviewed 147 manuscripts that presented findings from 56 pregnancy and two prepregnancy cohorts, 23 of which were ongoing. Half of the pregnancy cohorts were based in Europe. The most commonly described maternal exposures were nutrition, anthropometric measures, non-communicable diseases (NCDs), and demographic factors. Children’s mental, behavioural, neurodevelopmental, and physical outcomes were the most commonly measured outcomes. Fewer studies evaluated infectious disease, biomarkers, and environmental or workplace exposures. No cohorts examined vaccine or climate-related exposures during pregnancy. About half of the cohorts collected samples from pregnant women or the fetus and a third from children, with blood being the most common sample type. Most studies did not indicate how data or samples could be accessed. Conclusions This comprehensive overview of pregnancy and prepregnancy cohorts provides a foundation for cross-cohort coordination. Infectious disease, vaccine, environmental, and climate related exposures and microbiome, immune function, and economic outcomes remain underrepresented in pregnancy and prepregnancy cohorts.

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The Vitamin D in Pregnancy Study: a prospective prebirth cohort in southern Australia

Cited by 6 publications

References 38 publications

Demographic and clinical predictors of vitamin D status in pregnant women tested for deficiency in Western Australia

Demographic and clinical predictors of vitamin D status in pregnant women tested for deficiency in Western Australia

Gestational vitamin D and offspring fracture risk: do associations persist into mid adolescence?

The landscape of pregnancy and prepregnancy cohorts: a scoping review

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