Maternal vitamin D deficiency increases the thromboxane/prostacyclin ratio through alterations in the one‐carbon cycle in Wistar rats

Nandi, Anindita; Wadhwani, Nisha; Joshi, Sadhana

doi:10.1002/biof.1510

Cited by 10 publications

(5 citation statements)

References 62 publications

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“…One genetic target of vitamin D is cystathionine β‐synthase (CBS) which is required for transsulfuration pathway, the essentials for homocysteine disposal. In vitro study revealed that vitamin D deficiency induces elevated cellular homocysteine levels 31 and in vivo study showed that vitamin D deficiency was associated with hyperhomocysteinemia which increased thromboxane B2/prostacyclin ratio and induced endothelial dysfunction in pregnant rats 32 …”

Section: Vitamin Dmentioning

confidence: 99%

The impact of micronutrient deficiency on pregnancy complications and development origin of health and disease

Kanasaki

Kumagai

2021

J of Obstet and Gynaecol

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Due to the spread of the western style diet, which is characterized by high intake of processed food, micronutrients (vitamins and minerals) deficiency is increasing in the Japanese population of all ages and genders. During pregnancy, the elevated demand for micronutrients put pregnant women at even higher risk of micronutrients deficiency. Some micronutrients are relatively famous such that women with reproductive age are recommended to take folic acid supplementation for the prevention of neural tube defect. However, it is not generally known that folate is also important for fetal growth throughout the pregnancy course and for prevention of pregnancy complications, and that pregnant women should continue to take supplementation during pregnancy and lactation. The types of micronutrients and the duration of supplementation are both important factors to maintain normal pregnancies. This review focused on four micronutrients that are commonly deficient in Japanese pregnant women, folate, vitamin B12, vitamin D, calcium, and magnesium. The detrimental effects of homocysteine accumulation associated with the above micronutrient defects and its link to catechol‐o‐methyltransferase insufficiency are described. We also discussed possible molecular mechanisms of pregnancy complications and the development origin of health and disease (DOHaD) regarding micronutrient deficiencies from the point of view of one carbon metabolism.

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Section: Vitamin Dmentioning

confidence: 99%

The impact of micronutrient deficiency on pregnancy complications and development origin of health and disease

Kanasaki

Kumagai

2021

J of Obstet and Gynaecol

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“…A human study found that after cardioplegia/reperfusion, the human coronary microvasculature showed significantly decreased TXA 2 -induced vasoconstriction compared to that before procedures, while the protein level and gene expression of thromboxane synthase and thromboxane A 2 receptor did not differ in atrial tissue [33]. Vitamin-D-deficient pregnant female Wistar rats had higher placental mRNA levels and lower protein levels of phospholipase A2 and cyclooxigenase-2 compared to the control group, while serum thromboxane B 2 levels were similar between the groups [34]. Moreover, the VDD group had higher liver and plasma arachidonic acid levels than the control one [35].…”

Section: Discussionmentioning

confidence: 87%

Vitamin D Deficiency Reduces Vascular Reactivity of Coronary Arterioles in Male Rats

Fontányi

Sziva

Pál

et al. 2021

CIMB

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Background: Vitamin D deficiency (VDD) may be considered an independent cardiovascular (CV) risk factor, and it is well known that CV risk is higher in males. Our goal was to investigate the pharmacological reactivity and receptor expression of intramural coronary artery segments of male rats in cases of different vitamin D supply. Methods: Four-week-old male Wistar rats were divided into a control group (n = 11) with optimal vitamin D supply (300 IU/kgbw/day) and a VDD group (n = 11, <0.5 IU/kgbw/day). After 8 weeks of treatment, intramural coronary artery segments were microprepared, their pharmacological reactivity was examined by in vitro microangiometry, and their receptor expression was investigated by immunohistochemistry. Results: Thromboxane A2 (TXA2)-agonist induced reduced vasoconstriction, testosterone (T) and 17-β-estradiol (E2) relaxations were significantly decreased, a significant decrease in thromboxane receptor (TP) expression was shown, and the reduction in estrogen receptor-α (ERα) expression was on the border of significance in the VDD group. Conclusions: VD-deficient male coronary arteries showed deteriorated pharmacological reactivity to TXA2 and sexual steroids (E2, T). Insufficient vasoconstrictor capacity was accompanied by decreased TP receptor expression, and vasodilator impairments were mainly functional. The decrease in vasoconstrictor and vasodilator responses results in narrowed adaptational range of coronaries, causing inadequate coronary perfusion that might contribute to the increased CV risk in VDD.

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“…Furthermore, an animal study demonstrates that maternal deficiency of vitamin D influences FA metabolism and alters FA levels (Nandi et al, 2019a). Nandi et al (2019b) observed that maternal vitamin D deficiency increases the ratio of vasoconstrictor and vasodilator lipid metabolites of PUFA by increasing Hcy and oxidative stress levels.…”

Section: Vitamin B12 Statusmentioning

confidence: 99%

Docosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, and neural tube defects in Tunisian population

Nasri,

Ben Jamaa,

Siala Gaigi

et al. 2024

Birth Defects Research

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ObjectiveTo determine the effect of maternal status in (plasma and red blood cell) folate, vitamin B12, homocysteine, and vitamin D, as well as their interaction with MTHFR (C677T and A1298C) and MTRR A66G polymorphisms, on maternal plasma docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (ARA) levels and the risk of neural tube defects (NTDs).MethodsARA, EPA, and DHA composition was assessed using capillary gas chromatography.ResultsARA and DHA levels were higher in controls than in case mothers for low plasma folate status. For low red blood cell folate status, DHA levels were higher in controls than in case mothers. For high homocysteine levels, ARA and DHA levels were higher in controls than in case mothers. NTD mothers had lower EPA and DHA levels for low vitamin B12 levels. NTD mothers had lower DHA levels for low vitamin D levels. For low plasma folate status, DHA levels in the MTHFR C677T gene and ARA and EPA levels in MTHFR A1298C gene were different among the three genotypes in case mothers. DHA levels in the MTHFR C677T gene were different among the three genotypes in case mothers for both low and high homocysteine levels. For low vitamin B12 levels, ARA and DHA levels were different among the three genotypes of the MTHFR C677T gene in case mothers. In the MTHFR C677T gene, ARA and DHA levels were different among the three genotypes in case mothers for low vitamin D levels.ConclusionsMore advanced research is required to verify a suitable biochemical parameter status in relation to the genotypes in pregnant women.

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Maternal vitamin D deficiency increases the thromboxane/prostacyclin ratio through alterations in the one‐carbon cycle in Wistar rats

Cited by 10 publications

References 62 publications

The impact of micronutrient deficiency on pregnancy complications and development origin of health and disease

The impact of micronutrient deficiency on pregnancy complications and development origin of health and disease

Vitamin D Deficiency Reduces Vascular Reactivity of Coronary Arterioles in Male Rats

Docosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, and neural tube defects in Tunisian population

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