The impact of micronutrient deficiency on pregnancy complications and development origin of health and disease

Kanasaki, Keizo; Kumagai, Asako

doi:10.1111/jog.14770

Cited by 15 publications

(15 citation statements)

References 76 publications

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“…Moreover, the elevated demand for micronutrients during pregnancy leads to women being at high risk of vitamin D deficiency and periodontal disease; thus, adequate vitamin D supplementation plays a crucial role in pregnant women to reduce the risk of periodontal disease, and even the risk of PTB and LBW in newborns [ 95 , 99 , 100 ].…”

Section: Discussionmentioning

confidence: 99%

Periodontal Disease and Vitamin D Deficiency in Pregnant Women: Which Correlation with Preterm and Low-Weight Birth?

Ferrillo

Migliario

Roccuzzo

et al. 2021

JCM

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Periodontal disease seems to be correlated with low vitamin D serum levels, preterm birth (PTB) and low birth weight (LBW), although the literature still lacks a consensus. This study aimed to investigate this correlation in a cohort of pregnant women over 20 weeks of gestation from the University Hospital “Maggiore della Carità”, Novara, Italy. We assessed serum levels of vitamin D and oral health status through the following indexes: Oral Hygiene Index (OHI), Plaque Control Record (PCR), Gingival Bleeding Index (GBI), and Community Periodontal Index of Treatment Needs (CPTIN). Moreover, we assessed the number of PTB and LBW among the newborns. Out of 121 pregnant women recruited, 72 (mean age 29.91 ± 3.64 years) were included. There was a statistically significant correlation between preterm and OHI > 3 (p = 0.033), and between LBW and OHI > 3 (p = 0.005) and CPITN = 3 (p = 0.027). Both pregnant women with vitamin D deficiency ((25-hydroxy-vitamin D) < 30 ng/mL) and PTB plus LBW newborns were significantly correlated (p < 0.05) with poor levels of all oral health status indexes during pregnancy. Furthermore, these conditions (women with hypovitaminosis D and combination of PTB and LBW) were shown to be significantly correlated (p < 0.001). Taken together, our findings reported a high prevalence of PTB and LBW with poor oral health and vitamin D deficiency in pregnant women.

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Section: Discussionmentioning

confidence: 99%

Periodontal Disease and Vitamin D Deficiency in Pregnant Women: Which Correlation with Preterm and Low-Weight Birth?

Ferrillo

Migliario

Roccuzzo

et al. 2021

JCM

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“…Several micronutrient de ciencies correlate with adverse pregnancy outcomes, including PTB. Pregnant women have a higher demand for micronutrients, and complications can arise from maternal micronutrient de ciency (10).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency in pregnancy and the risk of preterm birth: a nested case-control study

Tahsin

Khanam

Chowdhury³

et al. 2023

Preprint

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Background: Each year, an estimated 15 million babies are born preterm. Micronutrient deficiencies, including vitamin D deficiency, are common in many low- and middle-income countries (LMICs), and these conditions are often associated with adverse pregnancy outcomes. Bangladesh experiences a high prevalence of vitamin D deficiency. The country also has a high preterm birth (PTB) rate. Using data from a population-based pregnancy cohort, we estimated the burden of vitamin D deficiency during pregnancy and its effect on PTB. Methods: Pregnant women (N=3,000) were enrolled after ultrasound confirmation of gestational age at 8-19 weeks of gestation. Trained health workers prospectively collected detailed phenotypic and epidemiological data at scheduled home visits. Trained phlebotomists collected maternal blood samples at enrollment and at 24 -28 weeks of gestation. Aliquots of serum were stored at -800 C. We conducted a nested case-control study, with all PTB (n=262) and a random sample of term births (n=668). We used the following data: vitamin D concentrations of 24-28 weeks maternal blood samples, ultrasound-determined gestational age, data on pregnancy outcomes, and other PTB risk factors data. PTB was defined as the birth of a baby <37 weeks of gestation. Women were categorized as vitamin D deficient (lowest quartile of 25(OH)D; <=30.18 nmol/L) or not deficient (upper-three quartiles of 25(OH)D; >30.18 nmol/L). We used logistic regression to determine the effect of vitamin D deficiency on PTB, adjusting for potential confounders. Results: The median and interquartile range of serum 25(OH)D was 38.0 nmol/L; 30.18 to 48.52 (nmol/L). After adjusting for co-variates, serum 25(OH)D deficiency was significantly associated with PTB [adjusted odds ratio (aOR) = 1.47, 95% confidence interval (CI) = 1.06 – 2.04]. The risk of PTB was also higher in primiparous women (aOR = 1.54, 95% CI = 1.12 – 2.12), passive smokers (aOR = 1.55, 95% CI = 1.06 – 2.26), and those who didn’t receive iron supplementation during pregnancy (aOR, 95% CI: 0.59, 0.41- 0.83). Conclusion: Vitamin D deficiency is common in Bangladeshi pregnant women, and these women experience an increased risk of PTB. Improving maternal vitamin D status during pregnancy may significantly reduce the risk of PTB.

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“…Previous studies revealed evidence of the negative impacts of micronutrient deficiencies during pregnancy in East Africa [ 12 – 16 ]. To reduce micronutrient deficiency among pregnant women, many national nutrition programs and micronutrient deficiency prevention and control measures have been established [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Micronutrient intake and associated factors among pregnant women in East Africa: Multilevel logistic regression analysis

et al. 2023

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Background Micronutrient deficiencies during pregnancy pose significant public health issues, considering the potential for negative consequences not only during pregnancy but also throughout life. Anemia in pregnant women is becoming a significant problem in developing countries, with scientific evidence indicating that 41.8 percent of women worldwide suffer from anemia. As a result, investigating the pooled prevalence and factors associated with micronutrient intake among pregnant women in East Africa is critical to alleviate the burden of micronutrient deficiency among pregnant women. Method The pooled prevalence of micronutrient intake with a 95% Confidence Interval (CI) was reported and presented in a forest plot for East Africa Countries using STATA version 14.1. Intra-class Correlation Coefficient (ICC), Likelihood Ratio (LR) test, Median Odds Ratio (MOR), and deviance (-2LLR) values were used for model comparison and fitness. Adjusted Odds Ratios (AOR) with a 95% Confidence Interval (CI) and p-value ≤0.05 in the multilevel logistic model were used to declare significant factors associated with micronutrient intake. Result The pooled prevalence of micronutrient intake in East African countries was 36.07% (95% CI: 35.82%, 36.33%). In the multilevel logistic regression model, women from the highest wealth quintile were 1.06 [AOR = 1.09, 95%CI: 1.00, 1.11] more likely to take micronutrients compared to their counterparts. Mothers who attained primary education, secondary education, and tertiary education had 1.20 times [AOR = 1.20, 95% CI: 1.15, 1.26], 1.28 times [AOR = 1.28, 95% CI: 1.19, 1.36] and 1.22 times [AOR = 1.22, 95% CI: 1.07, 1.38] more likely take micronutrient compared to mothers who attained no education, respectively. Conclusion The overall prevalence of micronutrient intake in East Africa was low. Only 36% of the study participants had micronutrient intake practice. Socioeconomic factors (education level, and household wealth status) have been shown to influence micronutrient intake. Therefore, it is necessitates the continuation of ongoing projects as well as the development of fresh ones that concentrate on these variables and include effective treatments and programs, especially among underprivileged and vulnerable populations.

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The impact of micronutrient deficiency on pregnancy complications and development origin of health and disease

Cited by 15 publications

References 76 publications

Periodontal Disease and Vitamin D Deficiency in Pregnant Women: Which Correlation with Preterm and Low-Weight Birth?

Periodontal Disease and Vitamin D Deficiency in Pregnant Women: Which Correlation with Preterm and Low-Weight Birth?

Vitamin D deficiency in pregnancy and the risk of preterm birth: a nested case-control study

Micronutrient intake and associated factors among pregnant women in East Africa: Multilevel logistic regression analysis

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