Maternal vitamin D deficiency and fetal distress/birth asphyxia: a population-based nested case–control study

Lindqvist, Pelle G.; Silva, Aldo T.; Gustafsson, Sven A.; Gidlöf, Sebastian

doi:10.1136/bmjopen-2015-009733

Cited by 19 publications

(14 citation statements)

References 35 publications

(42 reference statements)

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“…Furthermore, low vitamin D levels have been proposed to be associated with increased prevalence of fetal distress, as suggested in healthy women in a recent large nested case-control study (31). Vitamin D is suspected to alter the fetal heart in a way that makes it more vulnerable to fetal distress.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes – an observational study

Vestgaard

Secher

Ringholm

et al. 2017

Acta Obstet Gynecol Scand

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Introduction. The aim of this study was to evaluate whether vitamin D insufficiency is associated with preterm delivery and preeclampsia in women with type 1 diabetes. Material and methods. An observational study of 198 pregnant women with type 1 diabetes. 25-Hydroxy-Vitamin D and HbA1c were measured in blood samples in early (median 8 weeks, range 5-14) and late (34 weeks, range 32-36) pregnancy. Kidney involvement (microalbuminuria or nephropathy) at inclusion, smoking status at inclusion, preterm delivery (<37 weeks) and preeclampsia (blood pressure ≥140/ 90 mmHg and proteinuria) were registered. Vitamin D supplementation of 10 lg daily was routinely recommended. Results. Thirty-nine (20%) of the 198 women delivered preterm and 16 (8%) developed preeclampsia. Vitamin D insufficiency (<50 nmol/L) was present in 68 women (34%) in early pregnancy and in 73 women (37%) in late pregnancy. Preterm delivery occurred more frequently in women with vitamin D insufficiency in late pregnancy (27% vs. 15%, crude odds ratio 2.1; 95% confidence interval 1.0-4.3, p = 0.04). After adjustment for preexisting kidney involvement, HbA1c in late pregnancy and smoking the association became nonsignificant (adjusted odds ratio 1.8; 95% confidence interval 0.8-3.7). Preeclampsia developed in 11% of women with vitamin D insufficiency vs. 6% of the remaining women (crude odds ratio 1.8; 95% confidence interval 0.9-4.1, p = 0.25). Conclusion. In women with type 1 diabetes, preterm delivery was twice as frequent in women with vitamin D insufficiency in late pregnancy in crude analysis, but in this small study, low vitamin D was not independently associated with preterm birth or preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes – an observational study

Vestgaard

Secher

Ringholm

et al. 2017

Acta Obstet Gynecol Scand

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“…10 In another study done in Sweden by Lindqvist et al, the mean 25-OH vitamin D levels in women who underwent caesarean delivery due to suspected asphyxia was 43.6±18 nmol/L, which was significantly lower than in controls (p = 0.04). 11 Amegah et al, observed in his study done in Ghana, that 83% of the study population had serum 25(OH)D levels < 75 nmol/l which was considered as vitamin D deficiency. 4 These are a few studies done in different parts of the world and all these studies showed results comparable with this study.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of vitamin D levels in term pregnancy and its obstetric outcome in Indian women

Ciryam

Munikrishna

Dayanand

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Vitamin D deficiency is currently a global pandemic affecting all age groups. Vitamin D is considered a fundamental hormone in calcium homeostasis and bone health. Risk of vitamin D deficiency increases during pregnancy due to increased maternal and fetal demands and altered vitamin D metabolism. Recently, maternal vitamin D deficiency has been linked to adverse pregnancy outcomes, including preeclampsia, gestational diabetes, fetal growth restriction and preterm birth. Adequate vitamin D status appears to be relevant to health at all ages, and even in prenatal life.Methods: This is a cross sectional, observational study conducted in the department of obstetrics and gynaecology at R. L. Jalappa Hospital. A total number of 160 subjects were included. 5 ml of venous blood was collected and was centrifuged at 3000 rpm and stored at - 80°C till analysis. Analysis of 25-hydroxy Vitamin D was done using ELISA.Results: Majority of the subjects were vitamin D deficient (81.87%) and 12.5% were vitamin D insufficient and only 5.63% were vitamin D sufficient. The prevalence of vitamin D deficiency was more among primigravidas (85.6%) and was associated with higher rates of caesarean section (92.4%). High prevalence of vitamin D deficiency was seen in lower middle socioeconomic class (62.5%). Maternal vitamin D deficiency was associated low birth weight of neonates (100%).Conclusions: In this study it was concluded that majority of subjects were vitamin D deficient and belonged to lower middle socioeconomic class. Majority of this subjects who underwent caesarean section were vitamin D deficient. Vitamin D deficiency was associated only with low birth weight of neonates and no other adverse obstetric outcome.

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“…Thus, fetuses of vitamin D-deficient mothers might be more vulnerable to the hypoxic stress of delivery. Recently, it was shown that women with vitamin D deficiency in early pregnancy were more likely to undergo emergency cesarean delivery due to suspected fetal distress and the risk of newborn asphyxia was doubled (29).…”

Section: The Risk Of All-cause Death Due To Cardiovascular Disease (Cmentioning

confidence: 99%

The Winding Path Towards an Inverse Relationship Between Sun Exposure and All-cause Mortality

Lindqvist

2018

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Both UV exposure and fair skin are major contributors to skin cancer. Non-melanoma skin cancer (NMSC) (i.e. basal cell carcinoma and squamous cell carcinoma) is mainly related to cumulative UV radiation and has a good prognosis. Malignant melanoma is related to episodic overexposure to UV radiation and increased mortality (3). Since heavy skin coloration is selected for close to the equator and fair skin coloration at higher latitudes there is speculation of an evolutionary advantage to having skin coloration appropriate for the regional sun intensity. However, evidence is lacking.The aim of this review was to present how we came to the conclusion that there is an inverse relationship between sunexposure habits and all-cause mortality. Venous thromboembolism (VTE) and sun exposure.There is a great demand for lifestyle advice from women at increased risk of VTE (4, 5). There have been reports of seasonal changes in VTE incidence, with a nadir in summer (6-8). In addition, vitamin D deficiency is an inflammatory condition and all inflammatory conditions increase the risk of VTE (1, 9). The Melanoma in Southern Sweden (MISS) cohort was drawn from the Swedish population registry by computerized random selection in 1990. Approximately 40,000 women with no history of cancer were invited to participate and 29,518 answered an initial written questionnaire. The questionnaire detailed sun exposure habits, aiming to identify those with extremely high sun exposure habits. With interest in the opposite, namely those with the lowest sun exposure habits, in whom vitamin D-deficient women would be over-represented, four questions were identified that could be used to identify those with low sun exposure habits: (i) How often do you sunbathe during the summertime? (never, 1-14 times, 15-30 times, >30 times); (ii) Do you sunbathe during the winter, such as on holiday to the mountains? (no; 1-3 days, 4-10 days; >10 days); (iii) Do you use tanning beds? (never; 1-3 times/year; 4-10 times/year; >10 times/year); and (iv) Do you go abroad on holiday to swim and sunbathe? (never; once/1-2 years; once/year; two or more times/year). The four questions were 1173

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Maternal vitamin D deficiency and fetal distress/birth asphyxia: a population-based nested case–control study

Cited by 19 publications

References 35 publications

Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes – an observational study

Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes – an observational study

Evaluation of vitamin D levels in term pregnancy and its obstetric outcome in Indian women

The Winding Path Towards an Inverse Relationship Between Sun Exposure and All-cause Mortality

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