Maternal vaccination as an additional approach to improve the protection of the nursling: Anti-infective properties of breast milk

Zheng, Yingying; Correa‐Silva, Simone; Palmeira, Patrícia; Carneiro‐Sampaio, Magda

doi:10.1016/j.clinsp.2022.100093

Cited by 6 publications

(1 citation statement)

References 153 publications

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“…In fact, it has been hypothesized that mExos in breast milk aid the transfer of biologically active molecules from mother to child via the oral route, providing nutrition and important growth factors for the intestine, immunity, metabolism, and the nervous system. 37 Our earlier work showed a method for harvesting high yield and high purity bovine mExos, making them a viable natural oral delivery nanocarrier. 6 In previous reports, several drugs, including paclitaxel, insulin, and α-mangostin, were loaded in mExo and exhibited improved bioavailability compared to their freely delivered counterparts.…”

Section: Discussionmentioning

confidence: 99%

Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery

Zhang,

Millán Cotto

et al. 2024

Biomater. Sci.

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Section: Discussionmentioning

confidence: 99%

Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery

Zhang,

Millán Cotto

et al. 2024

Biomater. Sci.

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Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections

Sereme,

Toumi,

Saifi

et al. 2024

Cellular Immunology

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The cellular and immunological dynamics of early and transitional human milk

et al. 2023

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Human milk is essential for infant nutrition and immunity, providing protection against infections and other immune-mediated diseases during the lactation period and beyond in later childhood. Milk contains a broad range of bioactive factors such as nutrients, hormones, enzymes, immunoglobulins, growth factors, cytokines, and antimicrobial factors, as well as heterogeneous populations of maternal cells. The soluble and cellular components of milk are dynamic over time to meet the needs of the growing infant. In this study, we utilize systems-approaches to define and characterize 62 analytes of the soluble component, including immunoglobulin isotypes, as well as the cellular component of human milk during the first two weeks postpartum from 36 mothers. We identify soluble immune and growth factors that are dynamic over time and could be utilized to classify milk into different phenotypic groups. We identify 24 distinct populations of both epithelial and immune cells by single-cell transcriptome analysis of 128,016 human milk cells. We found that macrophage populations have shifting inflammatory profiles during the first two weeks of lactation. This analysis provides key insights into the soluble and cellular components of human milk and serves as a substantial resource for future studies of human milk.

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Maternal vaccination as an additional approach to improve the protection of the nursling: Anti-infective properties of breast milk

Cited by 6 publications

References 153 publications

Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery

Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery

Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections

The cellular and immunological dynamics of early and transitional human milk

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