Maternal use of acetaminophen and nonsteroidal anti‐inflammatory drugs (NSAIDs), and muscular ventricular septal defects

Cleves, Mario A.; Savell, Van H.; Sarika, Raj; Zhao, Wei‐Li; Correa, Adolfo; Werler, Martha M.; Hobbs, Charlotte A.

doi:10.1002/bdra.20005

Cited by 59 publications

(42 citation statements)

References 35 publications

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“…По имеющимся ранее представлениям, применение НПВП женщиной во время беременности не ассоциировалось с врожденными аномалиями, хотя увеличивало риск выкидыша. Позднее были опубликованы свидетельства возрастающего риска орофациальных расщелин и ВПС, в частности аномалий развития сердечной перегородки [78][79][80]. Ацетилсалициловая кислота (Аспирин) является единственным НПВП, который необратимо ингибирует ЦОГ путем ацетилирования, с чем, по-видимому, связана более высокая распространенность ВПР в исследова-ниях на животных [81].…”

Section: обзор литературыunclassified

Pharmacological safety during pregnancy: the principles of teratogenesis and teratogenicity of drugs

Reshetko¹,

Луцевич²,

Клименченко³

2016

Pediatr. farmakol.

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ВВЕДЕНИЕ В настоящее время в мировой медицинской лите-ратуре крайне мало данных о воздействии лекарствен-ных средств (ЛС) в период беременности -как на организм матери, так и ее будущего ребенка [1,2]. Многие ЛС способствуют развитию таких осложнений беременности, как самопроизвольный выкидыш, пре-ждевременные роды, мертворождение, а также могут вызывать формирование врожденных аномалий разви-тия, церебрального паралича, рождение с низкой мас-сой, задержку умственного развития и поведенческие нарушения в последующем и пр. При этом риск развития врожденных аномалий у ребенка может быть обуслов-лен как прямым воздействием препарата на систему «мать-будущий ребенок», так и через влияние ЛС на отдельные процессы в организме матери или самого

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Section: обзор литературыunclassified

Pharmacological safety during pregnancy: the principles of teratogenesis and teratogenicity of drugs

Reshetko¹,

Луцевич²,

Клименченко³

2016

Pediatr. farmakol.

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“…However, other investigations (e.g. Cleves 2004) do not indicate a developmental risk with paracetamol. This also applies to suicide attempts with paracetamol (McElhatton 1997).…”

mentioning

confidence: 90%

Analgesics and anti-inflammatory drugs

Reuvers¹,

Schaefer²

2007

Drugs During Pregnancy and Lactation

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“…In addition, a review of the literature shows that various maternal diseases, e.g., diabetes mellitus, infections, fever, as well as the treatment applied, may induce VSDs (1-3,9,10). It has been emphasized that prenatal exposure to cyclooxygenase (COX) inhibitors increases the risk of septal defects (2,(11)(12)(13)(14)(15)(16)(17)(18)(19). However, the dependence of these defects on maternal COX inhibitor exposure has never been fully confirmed.…”

Section: Introductionmentioning

confidence: 99%

“…Ventricular septal defects (VSDs) are the most common cardiac congenital anomalies (1)(2)(3). Their incidence ranges from 3 to 56 per 1000 newborns (2) depending on the screening methods used.…”

Section: Introductionmentioning

confidence: 99%

Congenital ventricular septal defects and prenatal exposure to cyclooxygenase inhibitors

Burdan

Szumiło

Dudka

et al. 2006

Braz J Med Biol Res

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Ventricular septal defects (VSDs) are common congenital abnormalities which have been reported to be associated with maternal fever and various environmental factors. The aim of the present study was to evaluate the effect of prenatal exposure to cyclooxygenase (COX) inhibitors on heart defects. A retrospective statistical analysis was performed using data collected in our laboratory during various teratological studies carried out on albino CRL:(WI)WUBR Wistar strain rats from 1997 to 2004. The observations were compared with concurrent and historic control data, as well as findings from other developmental toxicological studies with selective and nonselective COX-2 inhibitors. Despite the lack of significant differences in the frequency of VSDs between drug-exposed and control groups, statistical analysis by the two-sided Mantel-Haenszel test and historical control data showed a higher incidence of heart defects in offspring exposed to nonselective COX inhibitors (30.06/10,000). Unlike other specific inhibitors, aspirin (46.26/10,000) and ibuprofen (106.95/ 10,000) significantly increased the incidence of the VSD when compared with various control groups (5. 38-19.72/10,000). No significant differences in length or weight were detected between fetuses exposed to COX inhibitors and born with VSD and non-malformed offsprings. However, a statistically significant increase of fetal body length and decrease of body mass index were found in fetuses exposed to COX inhibitors when compared with untreated control. We conclude that prenatal exposure to COX inhibitors, especially aspirin and ibuprofen, increased the incidence of VSDs in rat offspring but was not related to fetal growth retardation.

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Maternal use of acetaminophen and nonsteroidal anti‐inflammatory drugs (NSAIDs), and muscular ventricular septal defects

Abstract: Significant associations were not detected between the occurrence of mVSDs and maternal use of NSAIDs or acetaminophen adjusting for maternal fever, nor were they detected between maternal fever and mVSDs.

Cited by 59 publications

References 35 publications

Pharmacological safety during pregnancy: the principles of teratogenesis and teratogenicity of drugs

Pharmacological safety during pregnancy: the principles of teratogenesis and teratogenicity of drugs

Analgesics and anti-inflammatory drugs

Congenital ventricular septal defects and prenatal exposure to cyclooxygenase inhibitors

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