Maternal thyrotropin is independently related to Small for Gestational Age neonates at term

Monen, L.; Kuppens, Simone; Hasaart, T. H. M.; Oosterbaan, Herman P.; Oei, S.G.; Wijnen, Hennie; Hutton, Eileen K.; Vader, Huib L.; Pop, Victor J M

doi:10.1111/cen.12578

Cited by 15 publications

(9 citation statements)

References 32 publications

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“…For example, Medici et al indicated no associations between early pregnancy maternal TPO‐Ab positivity and low birthweight. Ong et al in Australia suggested that TPO‐Ab positivity does not increase the risk of SGA, which is consistent with another study conducted by Monen et al However, the results from the Northern Finland Birth Cohort (NFBC) showed that TPO‐Ab‐positive mothers are more susceptible to having both low‐birthweight and LGA infants than are TPO‐Ab‐negative mothers. TPO‐Ab positivity might be a risk factor for birth outcomes, but TPO antibodies themselves could also have an independent effect .…”

Section: Discussionsupporting

confidence: 73%

The impact of isolated maternal hypothyroxinaemia on the incidence of large‐for‐gestational‐age infants: the Ma'anshan Birth Cohort study

Zhu

Yan

Huang

et al. 2018

BJOG

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Section: Discussionsupporting

confidence: 73%

The impact of isolated maternal hypothyroxinaemia on the incidence of large‐for‐gestational‐age infants: the Ma'anshan Birth Cohort study

Zhu

Yan

Huang

et al. 2018

BJOG

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“…Women with suboptimal thyroid function, mainly those with TPO-antibodies (thyroid-peroxidase-antibody), are at risk for miscarriage and preterm birth [ 9 , 10 ]. Furthermore, there is evidence that high maternal TSH might interfere with normal obstetric outcome at term, with higher incidences of small for gestational age neonates [ 11 ], gestational diabetes [ 10 ] and meconium stained amniotic fluid [ 12 ]. Low FT4 has been associated with poor fetal neurodevelopment and psychomotor development in early childhood [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Increased maternal TSH and decreased maternal FT4 are associated with a higher operative delivery rate in low-risk pregnancies: A prospective cohort study

Monen

Pop

Hasaart

et al. 2015

BMC Pregnancy Childbirth

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BackgroundThe increasing number of operative deliveries is a topic of major concern in modern obstetrics. Maternal thyroid function is of known influence on many obstetric parameters. Our objective was to investigate a possible relation between maternal thyroid function, and operative deliveries. Secondary aim was to explore whether thyroid function was related to specific reasons for operative deliveries.MethodsIn this prospective cohort study, low-risk Caucasian women, pregnant of a single cephalic fetus were included. Women with known auto-immune disease, a pre-labour Caesarean section, induction of labour, breech presentation or preterm delivery were excluded. In all trimesters of pregnancy the thyroid function was assessed. Differences in mean TSH and FT4 were assessed using t-test. Mean TSH and FT4 levels for operative deliveries were determined by one way ANOVA. Repeated measurement analyses were performed (ANOVA), adjusting for BMI, partiy, maternal age and gestational age at delivery.ResultsIn total 872 women were included, of which 699 (80.2 %) had a spontaneous delivery. At 36 weeks gestation women who had an operative delivery had a significantly higher mean TSH (1.63mIU/L versus 1.46mIU/L, p = 0.025) and lower mean FT4 (12.9pmol/L versus 13.3pmol/L, p = 0.007)) compared to women who had a spontaneous delivery. Mean TSH was significantly higher (p = 0.026) and mean FT4 significantly lower (p = 0.030) throughout pregnancy for women with an operative delivery due to failure to progress in second stage of labour, compared to women with a spontaneous delivery or operative delivery for other reasons.ConclusionsIncreased TSH and decreased FT4 seem to be associated with more operative vaginal deliveries and Caesarean sections. After adjusting for several confounders the association remained for operative deliveries due to failure to progress in second stage of labour, possibly to be explained by less efficient uterine action.

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“…A population-based cohort from the Netherlands indicated that a high FT4 level in early pregnancy, but not TSH level, are associated with LBW and an increased risk of SGA newborns in euthyroid women [13]. Another Dutch prospective cohort indicated that maternal TSH levels in the upper range of the reference interval in the first and third trimester are independently associated with an increased risk of SGA neonates at term; maternal FT4 levels and TPO-Ab positivity are not associated with SGA offspring [36]. A Spanish cohort study showed a significant inverse correlation of maternal FT4 and TSH levels at the first half of pregnancy with birthweight and indicated that high FT4 levels are associated with an increased risk of SGA [16].…”

Section: Discussionmentioning

confidence: 99%

Impact of maternal thyroid hormone in late pregnancy on adverse birth outcomes: A retrospective cohort study in China

et al. 2021

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The purpose of this study was to explore the impact of maternal thyroid hormone dysfunction in late pregnancy on birth outcomes in a Chinese population. We retrospectively examined hospitalisation records and laboratory data between April 2016 and March 2017 and obtained results from 11,564 consecutive pregnant women with singleton births in which serum thyroid hormone had been examined together with birth outcomes. We assessed the association between maternal thyroid level and dysfunction with adverse birth outcomes based on regression analysis. Hyperthyroidism was associated with an increased risk of preterm birth (PTB, adjusted OR: 2.41, 95% CI: 1.83-3.17) and hypothyroidism was associated with an increased risk of small for gestational age (SGA, adjusted OR: 1.56, 95% CI: 1.10-2.22), while hyperthyroxinaemia was associated with a decreased risk of large for gestational age (LGA, adjusted OR: 0.64, 95% CI: 0.45-0.90). In addition, compared to women with normal FT3 and TSH (≥the 5 th and ≤the 95 th percentiles), women with high free triiodothyronine (FT3 >the 95 th percentile) and low thyroid-stimulating hormone (TSH

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Maternal thyrotropin is independently related to Small for Gestational Age neonates at term

Abstract: Our data show that TSH levels in the upper range of the reference interval at different trimesters (3·0-3·29 mIU/l) are independently related to an increased risk of delivering SGA neonates at term.

Cited by 15 publications

References 32 publications

The impact of isolated maternal hypothyroxinaemia on the incidence of large‐for‐gestational‐age infants: the Ma'anshan Birth Cohort study

The impact of isolated maternal hypothyroxinaemia on the incidence of large‐for‐gestational‐age infants: the Ma'anshan Birth Cohort study

Increased maternal TSH and decreased maternal FT4 are associated with a higher operative delivery rate in low-risk pregnancies: A prospective cohort study

Impact of maternal thyroid hormone in late pregnancy on adverse birth outcomes: A retrospective cohort study in China

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