The impact of isolated maternal hypothyroxinaemia on the incidence of large‐for‐gestational‐age infants: the Ma'anshan Birth Cohort study

Zhu, Yuanduo; Yan, Han; Huang, Kun; Zhu, Beibei; Yan, Shuangqin; Ge, Xing; Zhou, Shusheng; Xu, Yuanyuan; Ren, Lingling; Sheng, Jie; Pan, Weijun; Hao, Jiahu; Zhu, Peng; Tao, Fangbiao

doi:10.1111/1471-0528.15107

Cited by 23 publications

(14 citation statements)

References 34 publications

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“…Similarly, Casey et al in the USA and Breathnach et al in Ireland reported that maternal hypothyroxinemia is not associated with LBW and intrauterine growth restriction [34,39]. In addition, we showed that higher FT4 levels (>95 th percentile) decrease the risk of LGA, which is in agreement with the recent study by Zhu et al, who reported that higher FT4 levels reduce the birthweight and are inversely related to LGA risk [40]. Furthermore, we showed no significant association of FT4 levels with pregnancy complications (GDM/ICP/ PIH) and adverse birth outcomes (PTB/SGA/LGA) after adjusting for maternal age and BMI, excluding PE (adjusted OR: 0.93, 95% CI: 0.88-0.99, p < 0.05).…”

Section: Discussionsupporting

confidence: 92%

Impact of maternal thyroid hormone in late pregnancy on adverse birth outcomes: A retrospective cohort study in China

et al. 2021

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The purpose of this study was to explore the impact of maternal thyroid hormone dysfunction in late pregnancy on birth outcomes in a Chinese population. We retrospectively examined hospitalisation records and laboratory data between April 2016 and March 2017 and obtained results from 11,564 consecutive pregnant women with singleton births in which serum thyroid hormone had been examined together with birth outcomes. We assessed the association between maternal thyroid level and dysfunction with adverse birth outcomes based on regression analysis. Hyperthyroidism was associated with an increased risk of preterm birth (PTB, adjusted OR: 2.41, 95% CI: 1.83-3.17) and hypothyroidism was associated with an increased risk of small for gestational age (SGA, adjusted OR: 1.56, 95% CI: 1.10-2.22), while hyperthyroxinaemia was associated with a decreased risk of large for gestational age (LGA, adjusted OR: 0.64, 95% CI: 0.45-0.90). In addition, compared to women with normal FT3 and TSH (≥the 5 th and ≤the 95 th percentiles), women with high free triiodothyronine (FT3 >the 95 th percentile) and low thyroid-stimulating hormone (TSH

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Section: Discussionsupporting

confidence: 92%

Impact of maternal thyroid hormone in late pregnancy on adverse birth outcomes: A retrospective cohort study in China

et al. 2021

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“…Elevated BMI has been found in pregnancy women with hypothyroxinemia in many studies [ 14 – 18 ]. In our study, participants with IMH identified in the first or second trimester also tended to have a higher BMI recorded in the early pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…However, the women with hypothyroxinemia were older than the controls, as well as less educated and more likely to smoke during their pregnancy. The Ma’anshan Birth Cohort (MABC) Study in China demonstrated that the risk of having a baby large for gestational age was increased among women with IMH in the second trimester (OR 2.088, 95% CI 1.193–3.654) [ 18 ]. A study in Henan, China found that women with IMH had a significant increase odd of having macrosomia (aOR 2.22, 95% CI 1.13–4.85) [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

The impact of isolated maternal hypothyroxinemia during the first and second trimester of gestation on pregnancy outcomes: an intervention and prospective cohort study in China

Gong

Liu

et al. 2018

J Endocrinol Invest

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Objectives To explore the effect of isolated maternal hypothyroxinemia (IMH) during the first and second trimester of gestation on pregnancy outcomes. To explore whether levothyroxine (L-T4) treatment of women who had IMH identified in the first trimester improves pregnancy outcomes. Methods Women in the early pregnancy in the iodine-sufficient area ( n = 3398) were recruited to this prospective cohort study (ChiCTR-TRC-12002326). Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), and thyroid peroxidase antibody (TPOAb) were detected. Women with IMH before 12 weeks chose to receive L-T4 or remain untreated. The L-T4 dose was adjusted to attain a normal FT4 and TSH level. Pregnancy outcomes were evaluated during follow-up. Results IMH in the first trimester was not associated with increased risk of adverse pregnancy outcome compared with controls. The incidence of macrosomia ( p = 0.022) and gestational hypertension ( p = 0.018) was significantly higher in IMH identified in the second trimester of gestation compared with controls. IMH identified in the second trimester of gestation was a risk factor for macrosomia [adjusted odds ratio (aOR) 1.942, 95% CI 1.076–3.503, p = 0.027] and gestational hypertension (aOR 4.203, 95% CI 1.611–10.968, p < 0.01), when body mass index in the early pregnancy was < 25 kg/m 2 . Conclusions IMH in the first trimester did not increase the risk of adverse outcomes irrespective of whether women received L-T4 treatment. However, IMH identified in the second trimester was associated with increased risk of adverse pregnancy outcome. The results suggest that thyroid function follow-up during the second trimester is necessary, even if thyroid function is normal during the first trimester. Electronic supplementary material The online version of this article (10.1007/s40618-018-0960-7) contains supplementary material, which is available to authorized users.

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“…Overt hypothyroidism and hyperthyroidism have a high risk of light birth weight or SGA births [11]. Mild thyroid dysfunction, which is more prevalent than overt hypothyroidism, is associated with SGA and LGA according to some studies [12][13][14][15], but not in other studies [16,17]. In euthyroid pregnant women, confirmed [20].…”

Section: Introductionmentioning

confidence: 95%

Association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes

Yan

Liu

et al. 2022

Endocrine Connections

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We aimed to explore the relationship between thyroid function and autoimmunity and adverse birth outcomes. Serum levels of thyroid function were detected by electrochemiluminescence assay. Urine iodine concentration was detected using the acid digestion method. We used multiple linear regression to assess the correlation between thyroid function indicators and birth weight according to trimester stratification, and binary logistic regression to evaluate the correlation between thyroid dysfunction and adverse birth outcomes. Reference ranges for trimester-specific thyroid hormones were established in our 2564 pregnant women cohort with mild iodine deficiency. The higher maternal TSH in the first trimester (β 0.09, p = 0.048) and total triiodothyronine (TT3) in the third trimester (β 0.16, p < 0.001) of TPOAb negative women, the higher birth weight Z-score. Whereas the second trimester free thyroxine (FT4) of mothers with TPOAb negative was lower (β -0.10, p = 0.026), the birth weight Z-score was higher. Pregnant women with overt and subclinical hyperthyroidism had a higher risk of preterm births than euthyroid women (11.9% vs. 4.5%; odds ratio [OR]: 2.84; p = 0.009). Women with higher TT3 had a higher risk of preterm (17.0% vs. 4.5%; OR: 4.19; p < 0.001) and LGA (34.0% vs. 11.1%; OR: 3.70; p < 0.001) births than euthyroid women. In conclusion, thyroid function during pregnancy could affect birth weight and birth outcome.

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The impact of isolated maternal hypothyroxinaemia on the incidence of large‐for‐gestational‐age infants: the Ma'anshan Birth Cohort study

Abstract: Isolated maternal hypothyroxinaemia may increase the risk of large-for-gestational-age infants.

Cited by 23 publications

References 34 publications

Impact of maternal thyroid hormone in late pregnancy on adverse birth outcomes: A retrospective cohort study in China

Impact of maternal thyroid hormone in late pregnancy on adverse birth outcomes: A retrospective cohort study in China

The impact of isolated maternal hypothyroxinemia during the first and second trimester of gestation on pregnancy outcomes: an intervention and prospective cohort study in China

Association of maternal thyroid dysfunction and autoimmunity with adverse birth outcomes

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