Maternal Thyroid Dysfunction During Pregnancy and Thyroid Function of Her Child in Adolescence

Abstract

Maternal thyroid dysfunction and TPO-Ab positivity during pregnancy seem to modify thyroid function parameters of offspring even in adolescence. Whether this increases the thyroid disease risk of the children is still unknown.

Iron Deficiency, An Independent Risk Factor for Isolated Hypothyroxinemia in Pregnant and Nonpregnant Women of Childbearing Age in China

“…The mean gestational age was 6.5 Ϯ 1.2 weeks for pregnant women. In pregnant women, the mean FT 4 level was higher (16.50 Ϯ 3.02 vs. 15.71 Ϯ 2.02 pmol/L, P Ͻ .001), and the median TSH level was lower (1.79 vs. 2.06 mIU/L, P Ͻ .001). The median SF level and mean TBI level of pregnant women were higher than those of nonpregnant women (64.76 vs. 51.27 g/L, P Ͻ .001 and 7.92 Ϯ 3.22 vs. 6.35 Ϯ 3.43 mg/kg, P Ͻ .001, respectively), and the median sTfR level was lower in pregnant women (2.67 vs. 3.11 mg/L, P Ͻ .001).…”

“…Hypothyroxinemia during early pregnancy have become a focus in the field of maternal thyroid disorders, because of its probable detrimental effects on neuropsychological development of the offspring (8,10,11), while some other studies showed the inconsistent results (12)(13)(14)(15). However, the causes of hypothyroxinemia have not been clarified yet.…”

“…Several recent studies have indicated that mild thyroid insufficiency, such as isolated hypothyroxinemia and subclinical hypothyroidism during pregnancy, can increase the prevalence of spontaneous abortion, placental abruption, preterm birth, fetal distress, and preeclampsia (1)(2)(3)(4)(5)(6)(7), and contribute to impaired cognitive outcome of the offspring (8 -11). However, some other studies did not indicate the adverse impact on these outcomes from hypothyroxinemia (12)(13)(14)(15). Although iodine deficiency and thyroid autoimmunity have been considered as the contributors for thyroid insufficiency, they can't explain the whole etiology of thyroid insufficiency.…”

Thyroid function and thyroid autoimmunity in apparently healthy pregnant and non-pregnant Mexican women

“…Maternal TPO-Ab positivity during pregnancy has also been linked to abnormal thyroid function parameters in the offspring, even in adolescence [21]. As the presence of TAI also suggests the potential for decreased thyroid functional reserve during pregnancy, ensuring proper maternal iodine nutrition in these women is especially important.…”

Nadczynność tarczycy w ciąży — rola oznaczania przeciwciał przeciwko receptorowi TSH i ultrasonograficznego monitorowania płodu

“…Short-term ATD therapy limited to the 1 st trimester resulted in normal foetal US performance observed in the 18 th -23 rd and the 30 th -33 rd WG. In view of the reports on the possible influence of maternal thyroid dysfunction during pregnancy on the pituitary-thyroid axis function in offspring [47], we compared the distribution of TSH levels obtained in dried-spot tests in children delivered by mothers with gestational hyperthyroidism and in the controls. No significant differences were noted between the two groups.…”