Maternal Thyroid Dysfunction during Gestation, Preterm Delivery, and Birthweight. The Infancia y Medio Ambiente Cohort, <scp>S</scp>pain

León, Gemma; Murcia, Mario; Rebagliato, Marisa; Álvarez-Pedrerol, Mar; Castilla, Ane Miren; Basterrechea, Mikel; Íñiguez, Carmen; Fernández-Somoano, Ana; Blarduni, Elizabeth; Foradada, Carles María; Tardón, Adonina; Vioque, Jesús

doi:10.1111/ppe.12172

Cited by 103 publications

(82 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are in agreement with a previous study showing associations between low FT4 concentrations (<2.5 th percentile) at median 13 weeks of pregnancy and an increased risk of preterm delivery [19]. However, null associations have been reported by other studies for low FT4 in early pregnancy [42–45] and for continuous measures of FT4 sampled in the first half of gestation [46, 47]. Currently, there are no published data on the relationship of total T3 concentrations with PTB.…”

Section: Discussionsupporting

confidence: 92%

Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth

et al. 2017

View full text Add to dashboard Cite

IntroductionOvert thyroid disease in pregnancy is associated with numerous maternal and neonatal complications including preterm birth. Less is known about the contribution of trimester-specific subclinical alterations in individual thyroid hormones, especially in late gestation, on the risk of preterm birth. Herein, we examined the associations between subclinical changes in maternal thyroid hormone concentrations (TSH, total T3, free and total T4), measured at multiple time points in pregnancy, and the odds of preterm birth in pregnant women without clinical thyroid disease.Participants and MethodsData were obtained from pregnant women participating in a nested case-control study of preterm birth within on ongoing birth cohort study at Brigham and Women’s Hospital in Boston, MA (N = 439; 116 cases and 323 controls). We measured thyroid hormones in plasma collected at up to four time points in pregnancy (median = 10, 18, 26, and 35 weeks). We used multivariate logistic regression models stratified by study visit of sample collection to examine associations. To reveal potential biological pathways, we also explored these relationships by obstetric presentation of preterm birth (e.g., spontaneous preterm delivery) that have been previously hypothesized to share common underlying mechanisms.ResultsIn samples collected at median 10 and 26 weeks of gestation, we found inverse associations between FT4 and the odds of overall preterm birth (odds ratio [OR] = 0.57, 95% confidence interval (CI) = 0.33, 1.00; and OR = 0.53, 95% CI = 0.34, 0.84, respectively). Positive associations were detected for total T3 at these same time points (OR = 2.52, 95% CI = 1.20, 5.31; and OR = 3.40, 95% CI = 1.56, 7.40, respectively). These effect estimates were stronger for spontaneous preterm birth.ConclusionsOur results suggest that subclinical alterations in individual maternal thyroid hormones may influence the risk of preterm birth, and the strength of these associations vary by gestational age.

show abstract

Section: Discussionsupporting

confidence: 92%

Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Nevertheless, this finding suggests that the third trimester of pregnancy, when the fetus significantly increases in size, is an important window of susceptibility to PM 2.5 exposure. Shields et al (2011), Medici et al (2013), and León et al (2015), as well as our study, report an inverse association between maternal FT 4 and birth weight, which is opposite to cord blood FT 4 . In a study of pregnant women without history of thyroid dysfunction, it has been shown that lower concentrations of FT 4 in maternal blood were related with increased placental growth (Bassols et al 2011).…”

Section: Discussionsupporting

confidence: 65%

Fetal Thyroid Function, Birth Weight, and in Utero Exposure to Fine Particle Air Pollution: A Birth Cohort Study

Janssen

Saenen

Roels

et al. 2017

Environ Health Perspect

View full text Add to dashboard Cite

Background:Thyroid hormones are critical for fetal development and growth. Whether prenatal exposure to fine particle air pollution (≤ 2.5 μm; PM2.5) affects fetal thyroid function and what the impact is on birth weight in normal healthy pregnancies have not been studied yet.Objectives:We studied the impact of third-trimester PM2.5 exposure on fetal and maternal thyroid hormones and their mediating role on birth weight.Methods:We measured the levels of free thyroid hormones (FT3, FT4) and thyroid-stimulating hormone (TSH) in cord blood (n = 499) and maternal blood (n = 431) collected after delivery from mother–child pairs enrolled between February 2010 and June 2014 in the ENVIRONAGE birth cohort with catchment area in the province of Limburg, Belgium.Results:An interquartile range (IQR) increment (8.2 μg/m3) in third-trimester PM2.5 exposure was inversely associated with cord blood TSH levels (–11.6%; 95% CI: –21.8, –0.1) and the FT4/FT3 ratio (–62.7%; 95% CI: –91.6, –33.8). A 10th–90th percentile decrease in cord blood FT4 levels was associated with a 56 g decrease in mean birth weight (95% CI: –90, –23). Assuming causality, we estimated that cord blood FT4 mediated 21% (–19 g; 95% CI: –37, –1) of the estimated effect of an IQR increment in third-trimester PM2.5 exposure on birth weight. Third-trimester PM2.5 exposure was inversely but not significantly associated with maternal blood FT4 levels collected 1 day after delivery (–4.0%, 95% CI: –8.0, 0.2 for an IQR increment in third-trimester PM2.5).Conclusions:In our study population of normal healthy pregnancies, third-trimester exposure to PM2.5 air pollution was associated with differences in fetal thyroid hormone levels that may contribute to reduced birth weight. Additional research is needed to confirm our findings in other populations and to evaluate potential consequences later in life.Citation:Janssen BG, Saenen ND, Roels HA, Madhloum N, Gyselaers W, Lefebvre W, Penders J, Vanpoucke C, Vrijens K, Nawrot TS. 2017. Fetal thyroid function, birth weight, and in utero exposure to fine particle air pollution: a birth cohort study. Environ Health Perspect 125:699–705; http://dx.doi.org/10.1289/EHP508

show abstract

“…Previous epidemiological studies have investigated potential IMH‐associated alterations in birthweight . A recent large cohort study from Rotterdam indicated that among euthyroid women, a high FT4 level but not TSH level, is related to SGA .…”

Section: Discussionmentioning

confidence: 99%

“…For example, van Mil et al found that maternal hypothyroxinaemia is associated with larger fetal and infant head sizes. Evidence from León et al also showed that IMH results in higher birthweight. In contrast, Su et al found that isolated hypothyroxinaemia is related to SGA, whereas other studies found no associations between IMH and low birthweight or SGA …”

Section: Introductionmentioning

confidence: 89%

The impact of isolated maternal hypothyroxinaemia on the incidence of large‐for‐gestational‐age infants: the Ma'anshan Birth Cohort study

Zhu

Yan

Huang

et al. 2018

BJOG

View full text Add to dashboard Cite

show abstract

Maternal Thyroid Dysfunction during Gestation, Preterm Delivery, and Birthweight. The Infancia y Medio Ambiente Cohort, Spain

Cited by 103 publications

References 33 publications

Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth

Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth

Fetal Thyroid Function, Birth Weight, and in Utero Exposure to Fine Particle Air Pollution: A Birth Cohort Study

The impact of isolated maternal hypothyroxinaemia on the incidence of large‐for‐gestational‐age infants: the Ma'anshan Birth Cohort study

Contact Info

Product

Resources

About